Where Have All the Emergencies Gone? The Impact of the COVID-19 Pandemic on Obstetric and Gynecologic Procedures and Consults at a New York City Hospital

Study ObjectiveThe purpose of this study was to assess the impact of the coronavirus disease 2019 (COVID-19) pandemic on surgical volume and emergency department (ED) consults across obstetrics-gynecology (OB-GYN) services at a New York City hospital.DesignRetrospective cohort study.SettingTertiary care academic medical center in New York City.PatientsWomen undergoing OB-GYN ED consults or surgeries between February 1, 2020 and April 15, 2020.InterventionsMarch 16 institutional moratorium on elective surgeries.Measurements and Main ResultsThe volume and types of surgeries and ED consults were compared before and after the COVID-19 moratorium. During the pandemic, the average weekly volume of ED consults and gynecology (GYN) surgeries decreased, whereas obstetric (OB) surgeries remained stable. The proportions of OB-GYN ED consults, GYN surgeries, and OB surgeries relative to all ED consults, all surgeries, and all labor and delivery patients were 1.87%, 13.8%, 54.6% in the pre–COVID-19 time frame (February 1–March 15) vs 1.53%, 21.3%, 79.7% in the COVID-19 time frame (March 16–April 15), representing no significant difference in proportions of OB-GYN ED consults (p = .464) and GYN surgeries (p = .310) before and during COVID-19, with a proportionate increase in OB surgeries (p <.002). The distribution of GYN surgical case types changed significantly during the pandemic with higher proportions of emergent surgeries for ectopic pregnancies, miscarriages, and concern for cancer (p <.001). Alternatively, the OB surgery distribution of case types remained relatively constant.ConclusionThis study highlights how the pandemic has affected the ways that patients in OB-GYN access and receive care. Institutional policies suspending elective surgeries during the pandemic decreased GYN surgical volume and affected the types of cases performed. This decrease was not appreciated for OB surgical volume, reflecting the nonelective and time-sensitive nature of obstetric care. A decrease in ED consults was noted during the pandemic begging the question “Where have all the emergencies gone?” Although the moratorium on elective procedures was necessary, “elective” GYN surgeries remain medically indicated to address symptoms such as pain and bleeding and to prevent serious medical sequelae such as severe anemia requiring transfusion. As we continue to battle COVID-19, we must not lose sight of those patients whose care has been deferred.     

Detection of Platelet-Monocyte Aggregates by the ADAM? Image Cytometer

Background: Inappropriate platelet activation is known to be associated with various thrombotic disorders. Platelet-monocyte aggregates (PMAs), whose formation is mediated by platelet surface P-selectin (CD62P), can be used as a reliable marker to detect platelet activation. Previous studies have generally detected PMAs through flow cytometry-based approaches. Recently, the ADAM^® image cytometer (Nanoentek Inc., Seoul, Korea) was developed for image-based cellular analysis. In this study, we detected PMAs with the ADAM^® cytometer, evaluated the reproducibility of the measurements made by the ADAM^® cytometer, and compared the abilities of the ADAM^® cytometer and a flow cytometric assay to detect PMAs.Methods: Whole blood samples were collected from patients. Within 5 minutes of collection, anticoagulated whole blood samples were fixed in 10% paraformaldehyde and 5% glyoxal. Nineteen clinical specimens were collected; each was analyzed three times with the ADAM^® cytometer in order to assess the reproducibility of its measurements. To compare the ability of the ADAM^® cytometer with that of a flow cytometer to detect PMAs, each cytometer was used for 23 clinical samples and the correlation of the measurements was determined.Results: The PMA measurements made by the ADAM^® cytometer showed good reproducibility (CV < 10% for all specimens). Moreover, the PMA measurements made by the ADAM^® cytometer exhibited a high correlation with those made by a flow cytometric assay (R = 0.944).Conclusions: The ADAM^® cytometer is a suitable alternative method to the flow cytometry-based assays. Since the ADAM cytometer does not need specialized instrument knowledge or software proficiency (unlike flow cytometry), the ADAM^® cytometer can be used as a rapid and reliable POCT device to measure platelet activation in peripheral blood. This, in turn, will provide valuable information regarding patient propensities to thrombotic diseases.     

Classification system for flexor digitorum accessorius longus muscle variants within the leg: Clinical correlations

The flexor digitorum accessorius longus (FDAL), a variant leg muscle, can cause tarsal tunnel syndrome. This study was performed to classify the variants of the FDAL by dissection and to correlate the dissection results with clinical cases of tarsal tunnel syndrome caused by this muscle. Eighty lower limbs of embalmed Korean cadavers were dissected. MR images of two clinical cases of tarsal tunnel syndrome caused by the FDAL were correlated with the dissection results. The FDAL was observed in nine out of 80 specimens (11.3%) and it was classified into three types depending on its site of origin and its relationship to the posterior tibial neurovascular bundle (PTNV) in the leg. In Type I (6.3%), the FDAL originated in the leg and ran superficially along the PTNV, either not crossing (Type Ia, 3.8%) or crossing (Type Ib, 2.5%) the neurovascular bundle. In Type II (6.3%), it originated in the tarsal tunnel. Most FDALs followed a similar course in the tarsal tunnel and the plantar pedis. On correlating the MR images of the clinical cases with this classification, the FDAL corresponded to Types Ia and II. All three types of FDAL can compress the tibial nerve in the tarsal tunnel or the distal leg. Clarification of the topographical relationship between this muscle and the PTNV would help to improve the results of surgery for tarsal tunnel syndrome caused by the FDAL. Clin. Anat. 27:1111–1116, 2014. © 2014 Wiley Periodicals, Inc.     

The Metabolic Syndrome and Microvascular Complications in a Murine Model of Type 2 Diabetes

To define the components of the metabolic syndrome that contribute to diabetic polyneuropathy (DPN) in type 2 diabetes mellitus (T2DM), we treated the BKS db/db mouse, an established murine model of T2DM and the metabolic syndrome, with the thiazolidinedione class drug pioglitazone. Pioglitazone treatment of BKS db/db mice produced a significant weight gain, restored glycemic control, and normalized measures of serum oxidative stress and triglycerides but had no effect on LDLs or total cholesterol. Moreover, although pioglitazone treatment normalized renal function, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic nerve conduction velocities, but significantly improved measures of small unmyelinated nerve fiber architecture and function. Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated animals revealed an unanticipated increase in genes related to adipogenesis, adipokine signaling, and lipoprotein signaling, which likely contributed to the blunted therapeutic response. Similar analyses of dorsal root ganglion neurons revealed a salutary effect of pioglitazone on pathways related to defense and cytokine production. These data suggest differential susceptibility of small and large nerve fibers to specific metabolic impairments associated with T2DM and provide the basis for discussion of new treatment paradigms for individuals with T2DM and DPN.     

Torsional strength and toughness of nickel-titanium rotary files

Introduction

The aim of this investigation was to compare torsional strength, distortion angle, and toughness of various nickel-titanium (NiTi) rotary files.

Methods

Five NiTi rotary instruments with different cross-sectional geometries were selected: TF and RaCe with equilateral triangle, ProTaper with convex-triangle, ProFile with U-shape, and Mtwo with S-shape. The size 25/.06 taper of TF, RaCe, ProFile, and Mtwo and the ProTaper F1 files were tested, all with the same diameter at D5. A metal mounting block with a cubical hole was constructed in which 5 mm of the file tip was rigidly held in place by filling the mold with a resin composite. The files were subjected to clockwise rotation at 2 rpm in a torsion tester. The torque and angular distortion were monitored until the file failed. The data were compared statistically for the yield and ultimate strengths, plastic hardening period, and toughness.

Results

TF and RaCe had significantly lower yield strength than other systems. TF had a significantly lower ultimate strength than other files, whereas Mtwo showed the greatest. ProFile showed the highest distortion angle at break, followed by TF. ProFile also showed the highest toughness value, whereas TF and RaCe both showed a lower toughness value than the others (P < .05). Fractographic examination revealed typical pattern of torsional fracture for all brands, characterized by circular abrasion marks and skewed dimples near the center of rotation.

Conclusions

Under the limitations of the present study, the 5 tested NiTi rotary files showed a similar mechanical behavior under torsional load, with a period of plastic deformation before actual torsional breakage but with unequal strength and toughness value.