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1.
Marco N. Iannone Stefano Stucchi Elia A. Turolla Chiara Beretta Samuele Ciceri Clizia Chinello Lisa Pagani Sergio Todde Patrizia Ferraboschi 《Journal of labelled compounds & radiopharmaceuticals》2022,65(3):48-62
In the last decade, the development of new radiopharmaceuticals for the imaging and therapy of prostate cancer has been a highly active and important area of research, especially focusing on the prostate-specific membrane antigen (PSMA), an antigen which is upregulated in prostate, as well as in other tumor cells. A large variety of PSMA ligands have been radiolabeled, to date. Among the various derivatives, PSMA-617 resulted to be one of the most interesting in terms of interaction with the antigen and clinical properties, and its lutetium-177 labeled version has recently been approved by regulatory agencies for therapeutic purposes. For this reasons, the radiolabeling with fluorine-18 of a PSMA-617 derivative might be of interest. Beside other methodologies to radiolabel macromolecules with fluorine-18, the “click-chemistry” approach resulted to be very useful, and the copper-catalyzed azide-alkyne cycloaddition (CuAAC) is considered one of most efficient and reliable. This paper proposes the synthesis of a suitable precursor for the radiolabeling with fluorine-18 of a new PSMA-617 derivative. The whole radiosynthetic procedure has been fully automated, and the final product, which proved to be stable in plasma, has been obtained with radiochemical yield and purity suitable for subsequent preclinical studies. 相似文献
2.
Milani Paolo Mazzola Marco Cigada Mario Massacesi Amedeo Setaccioli Marco Moschini Stefania Ciaccia Stefano Scotti Fabrizio Mantovani Elena Soranna Davide Zambon Antonella Bergamini Fulvio 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(9):2847-2857
Graefe's Archive for Clinical and Experimental Ophthalmology - To propose an algorithm of the major and minor diagnostic criteria for macular myopic choroidal neovascularization (mCNV). This... 相似文献
3.
Andrea Ronchi MD Marco Montella MD Federica Zito Marino BD PhD Giuseppe Argenziano MD PhD Elvira Moscarella MD Gabriella Brancaccio MD Giuseppe Ferraro MD Giovanni Francesco Nicoletti MD Teresa Troiani MD Renato Franco MD PhD Immacolata Cozzolino MD PhD 《Cancer cytopathology》2022,130(1):18-29
Malignant melanoma (MM) is a highly aggressive neoplasm with a growing worldwide incidence. It is not uncommon that the disease is already metastatic at the time of the first diagnosis. Regional lymph nodes and skin are the first and most common metastatic sites, followed by distant visceral sites (lungs, liver, and central nervous system) and bone. In this clinical setting, fine-needle aspiration (FNA) often represents the first diagnostic approach. FNA is a useful tool to obtain a rapid and accurate diagnosis, in conjunction with ancillary techniques and molecular analysis, as recommended by recent guidelines. The aim of this review was to describe the cytomorphology, immunocytochemical tools, and molecular tools used for the diagnosis of MM metastases on FNA. 相似文献
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5.
Heramvand Nadia Masyuk Maryna Muessig Johanna M. Nia Amir M. Karathanos Athanasios Polzin Amin Valgimigli Marco Gurbel Paul A. Tantry Udaya S. Kelm Malte Jung Christian 《Journal of thrombosis and thrombolysis》2022,54(2):301-308
Journal of Thrombosis and Thrombolysis - Tirofiban is a glycoproteine (GP) IIb/IIIa receptor antagonist, which inhibits platelet-platelet aggregation and is a potential adjunctive antithrombotic... 相似文献
6.
van der Meulen Merel Verstegen Marco J. T. Lobatto Daniel J. Kleijwegt Maarten C. Pereira Alberto M. Biermasz Nienke R. van Furth Wouter R. Zamanipoor Najafabadi Amir H. 《Pituitary》2022,25(2):308-320
Pituitary - Endoscopic transsphenoidal surgery causes nasal morbidity and negatively affects health-related quality of life (HRQoL). Knowledge on actionable symptoms that could improve... 相似文献
7.
Patel Parth S. Uppuluri Aditya Zarbin Marco A. Bhagat Neelakshi 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2022,260(4):1387-1394
Graefe's Archive for Clinical and Experimental Ophthalmology - Epidemiologic studies related to the demographics and trends of ocular injury in the pediatric cohort in the last decade are... 相似文献
8.
Slonimsky Einat Upham Kent Pepley Sarah Ouyang Tao King Tonya Fiorelli Marco Thamburaj Krishnamoorthy 《Emergency radiology》2022,29(3):427-435
Emergency Radiology - In subarachnoid hemorrhage, noncontrast CT features are used to guide the localization of ruptured aneurysms on CT angiography and DSA. Multiplanar CT may improve the... 相似文献
9.