全文获取类型
收费全文 | 7431篇 |
免费 | 454篇 |
国内免费 | 52篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 94篇 |
妇产科学 | 63篇 |
基础医学 | 1066篇 |
口腔科学 | 121篇 |
临床医学 | 785篇 |
内科学 | 1694篇 |
皮肤病学 | 157篇 |
神经病学 | 833篇 |
特种医学 | 358篇 |
外科学 | 975篇 |
综合类 | 30篇 |
一般理论 | 14篇 |
预防医学 | 511篇 |
眼科学 | 91篇 |
药学 | 605篇 |
中国医学 | 33篇 |
肿瘤学 | 448篇 |
出版年
2023年 | 41篇 |
2022年 | 34篇 |
2021年 | 126篇 |
2020年 | 122篇 |
2019年 | 170篇 |
2018年 | 198篇 |
2017年 | 142篇 |
2016年 | 176篇 |
2015年 | 219篇 |
2014年 | 297篇 |
2013年 | 389篇 |
2012年 | 599篇 |
2011年 | 614篇 |
2010年 | 362篇 |
2009年 | 342篇 |
2008年 | 566篇 |
2007年 | 584篇 |
2006年 | 513篇 |
2005年 | 480篇 |
2004年 | 423篇 |
2003年 | 362篇 |
2002年 | 347篇 |
2001年 | 45篇 |
2000年 | 42篇 |
1999年 | 51篇 |
1998年 | 59篇 |
1997年 | 51篇 |
1996年 | 32篇 |
1995年 | 47篇 |
1994年 | 24篇 |
1993年 | 36篇 |
1992年 | 25篇 |
1991年 | 17篇 |
1990年 | 23篇 |
1989年 | 19篇 |
1988年 | 15篇 |
1987年 | 26篇 |
1986年 | 27篇 |
1985年 | 16篇 |
1984年 | 12篇 |
1983年 | 9篇 |
1982年 | 22篇 |
1981年 | 20篇 |
1980年 | 18篇 |
1978年 | 15篇 |
1977年 | 9篇 |
1976年 | 13篇 |
1973年 | 13篇 |
1971年 | 10篇 |
1963年 | 8篇 |
排序方式: 共有7937条查询结果,搜索用时 15 毫秒
1.
Hendrik Kröning Thomas Göhler Thomas Decker Marc Grundeis Georgi Kojouharoff Jörg Lipke Dieter Semsek Enno Moorahrend Annette Sauer Harald-Robert Bruch Rüdiger Liersch Arnd Nusch Ursula Vehling-Kaiser Manfred Welslau Ralf Grunewald Hanns-Detlev Harich Marcel Stephany Jens Uhlig Rebecca de Buhr Melanie Frank Cathrin Hogrefe Norbert Marschner Karin Potthoff Frank Hartmann Timo Reisländer Ingo Schwaner 《International journal of cancer. Journal international du cancer》2023,153(6):1227-1240
The prospective, multicenter, noninterventional TACTIC study assessed effectiveness and safety of trifluridine/tipiracil (FTD/TPI) in patients with metastatic colorectal cancer (mCRC) in a real-world setting in Germany, thus evaluating the external validity of the findings from the pivotal RECOURSE trial. Primary endpoint was overall survival (OS). Secondary objectives included progression-free survival (PFS), safety, and quality of life (QoL). Subgroups comprised patients with good (<3 metastatic sites at inclusion, ≥18 months from diagnosis of first metastasis to inclusion) or poor (remaining patients) prognostic characteristics (GPC/PPC). GPC without liver metastases was considered best prognostic characteristics (BPC). In total, 307 eligible patients (pretreated or not suitable for other available therapies) were treated with FTD/TPI. Overall, median [95%-CI] OS was 7.4 months [6.4-8.6], median PFS was 2.9 months [2.8-3.3]. In BPC (n = 65) and GPC (n = 176) compared to PPC (n = 124) subgroup, median OS (13.3 [9.1-17.6] vs 8.9 [7.6-9.8] vs 5.1 [4.4-7.0] months) and median PFS (4.0 [3.3-5.3] vs 3.4 [3.0-3.7] vs 2.6 [2.4-2.8] months) were longer. Patient-reported QoL, assessed by validated questionnaires (EQ-5D-5L, PRO-CTCAE), was stable throughout FTD/TPI treatment. Predominant FTD/TPI-related adverse events of grades 3 or 4 were neutropenia (13.0%), leukopenia (7.5%), and anemia (5.2%). Altogether, palliative FTD/TPI therapy in patients with pretreated mCRC was associated with prolonged survival, delayed progression, maintained health-related QoL, and manageable toxicity. Low metastatic burden and indolent disease were favorable prognostic factors for survival. TACTIC confirms the effectiveness and safety of FTD/TPI, highlighting its value in routine clinical practice. 相似文献
2.
3.
Miriam L. Haaksma Debora Rizzuto Inez H.G.B. Ramakers Sara Garcia-Ptacek Alessandra Marengoni Wiesje M. van der Flier Frans R.J. Verhey Marcel G.M. Olde Rikkert René J.F. Melis 《Journal of the American Medical Directors Association》2019,20(2):165-170.e2
Objectives
The predictive value of frailty and comorbidity, in addition to more readily available information, is not widely studied. We determined the incremental predictive value of frailty and comorbidity for mortality and institutionalization across both short and long prediction periods in persons with dementia.Design
Longitudinal clinical cohort study with a follow-up of institutionalization and mortality occurrence across 7 years after baseline.Setting and Participants
331 newly diagnosed dementia patients, originating from 3 Alzheimer centers (Amsterdam, Maastricht, and Nijmegen) in the Netherlands, contributed to the Clinical Course of Cognition and Comorbidity (4C) Study.Measures
We measured comorbidity burden using the Cumulative Illness Rating Scale for Geriatrics (CIRS-G) and constructed a Frailty Index (FI) based on 35 items. Time-to-death and time-to-institutionalization from dementia diagnosis onward were verified through linkage to the Dutch population registry.Results
After 7 years, 131 patients were institutionalized and 160 patients had died. Compared with a previously developed prediction model for survival in dementia, our Cox regression model showed a significant improvement in model concordance (U) after the addition of baseline CIRS-G or FI when examining mortality across 3 years (FI: U = 0.178, P = .005, CIRS-G: U = 0.180, P = .012), but not for mortality across 6 years (FI: U = 0.068, P = .176, CIRS-G: U = 0.084, P = .119). In a competing risk regression model for time-to-institutionalization, baseline CIRS-G and FI did not improve the prediction across any of the periods.Conclusions
Characteristics such as frailty and comorbidity change over time and therefore their predictive value is likely maximized in the short term. These results call for a shift in our approach to prognostic modeling for chronic diseases, focusing on yearly predictions rather than a single prediction across multiple years. Our findings underline the importance of considering possible fluctuations in predictors over time by performing regular longitudinal assessments in future studies as well as in clinical practice. 相似文献4.
Heterogeneity of glioblastoma with gliomatosis cerebri growth pattern on diffusion and perfusion MRI
Förster Alex Brehmer Stefanie Seiz-Rosenhagen Marcel Mildenberger Iris Giordano Frank A. Wenz Holger Reuss David Hänggi Daniel Groden Christoph 《Journal of neuro-oncology》2019,141(1):103-109
Journal of Neuro-Oncology - Gliomatosis cerebri (GC) is a rare growth pattern of glioblastoma whose diffuse nature is reflected by unspecific, relatively uniform findings on conventional MRI. In... 相似文献
5.
Alba Tristán-Noguero PhD Eva Borràs PhD Marta Molero-Luis PhD Tessa Wassenberg MD PhD Tessa Peters MSc Marcel M. Verbeek PhD Michel Willemsen MD PhD Thomas Opladen MD PhD Kathrin Jeltsch PhD Roser Pons MD PhD Beat Thony PhD Gabriella Horvath MD Zuhal Yapici MD Jennifer Friedman MD Keith Hyland PhD Guillermo E. Agosta MD Eduardo López-Laso MD Rafael Artuch MD PhD Eduard Sabidó PhD Àngels García-Cazorla MD PhD 《Movement disorders》2021,36(3):690-703
6.
7.
John Whyte Marcel P. Dijkers Tessa Hart Jarrad H. Van Stan Andrew Packel Lyn S. Turkstra Jeanne M. Zanca Christine Chen Mary Ferraro 《Archives of physical medicine and rehabilitation》2019,100(1):156-163
Most rehabilitation treatments are volitional in nature, meaning that they require the patient’s active engagement and effort. Volitional treatments are particularly challenging to define in a standardized fashion, because the clinician is not in complete control of the patient’s role in enacting these treatments. Current recommendations for describing treatments in research reports fail to distinguish between 2 fundamentally different aspects of treatment design: the selection of treatment ingredients to produce the desired functional change and the selection of ingredients that will ensure the patient’s volitional performance. The Rehabilitation Treatment Specification System (RTSS) is a conceptual scheme for standardizing the way that rehabilitation treatments are defined by all disciplines across all areas of rehabilitation. The RTSS highlights the importance of volitional behavior in many treatment areas and provides specific guidance for how volitional treatments should be specified. In doing so, it suggests important crosscutting research questions about the nature of volitional behavior, factors that make it more or less likely to occur, and ingredients that are most effective in ensuring that patients perform desired treatment activities. 相似文献
8.
9.
Evaluation of the biocompatibility of root canal sealers on human periodontal ligament cells ex vivo
Jung Susanne Libricht Viktor Sielker Sonja Hanisch Marcel R. Schäfer Edgar Dammaschke Till 《Odontology / the Society of the Nippon Dental University》2019,107(1):54-63
Odontology - The aim of this study was to evaluate the biocompatibility of two comparatively new calcium silicate containing sealers (MTA-Fillapex and BioRoot-RCS) with that of two established... 相似文献
10.