全文获取类型
收费全文 | 2952篇 |
免费 | 214篇 |
国内免费 | 150篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 136篇 |
妇产科学 | 29篇 |
基础医学 | 242篇 |
口腔科学 | 75篇 |
临床医学 | 408篇 |
内科学 | 551篇 |
皮肤病学 | 72篇 |
神经病学 | 220篇 |
特种医学 | 358篇 |
外科学 | 218篇 |
综合类 | 107篇 |
一般理论 | 2篇 |
预防医学 | 237篇 |
眼科学 | 180篇 |
药学 | 291篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 172篇 |
出版年
2023年 | 11篇 |
2021年 | 31篇 |
2020年 | 27篇 |
2019年 | 33篇 |
2018年 | 56篇 |
2017年 | 42篇 |
2016年 | 37篇 |
2015年 | 45篇 |
2014年 | 63篇 |
2013年 | 90篇 |
2012年 | 106篇 |
2011年 | 103篇 |
2010年 | 68篇 |
2009年 | 83篇 |
2008年 | 95篇 |
2007年 | 210篇 |
2006年 | 104篇 |
2005年 | 119篇 |
2004年 | 95篇 |
2003年 | 93篇 |
2002年 | 110篇 |
2001年 | 90篇 |
2000年 | 104篇 |
1999年 | 104篇 |
1998年 | 105篇 |
1997年 | 91篇 |
1996年 | 87篇 |
1995年 | 78篇 |
1994年 | 67篇 |
1993年 | 66篇 |
1992年 | 46篇 |
1991年 | 69篇 |
1990年 | 58篇 |
1989年 | 103篇 |
1988年 | 67篇 |
1987年 | 63篇 |
1986年 | 53篇 |
1985年 | 50篇 |
1984年 | 39篇 |
1983年 | 35篇 |
1982年 | 46篇 |
1981年 | 29篇 |
1980年 | 33篇 |
1979年 | 26篇 |
1978年 | 14篇 |
1977年 | 29篇 |
1976年 | 35篇 |
1975年 | 19篇 |
1972年 | 13篇 |
1970年 | 10篇 |
排序方式: 共有3316条查询结果,搜索用时 93 毫秒
1.
Renuka V. Iyer MD Bhavana Konda MD MPH Christos Fountzilas MD Sarbajit Mukherjee MD MS Dwight Owen MD MS Kristopher Attwood PhD Chong Wang MA Orla Maguire PhD Hans Minderman PhD Sheryl-Ann Suffren BA Karen Hicks BS John Wilton PhD Robert Bies PhD Danielle Casucci BA Diane Reidy-Lagunes MD Manisha Shah MD 《Cancer》2020,126(16):3689-3697
2.
3.
Yi Gong Dakai Mu Shilpa Prabhakar Ann Moser Patricia Musolino JiaQian Ren Xandra O Breakefield Casey A Maguire Florian S Eichler 《Molecular therapy》2015,23(5):824-834
X-linked adrenoleukodystrophy (X-ALD) is a devastating neurological disorder caused by mutations in the ABCD1 gene that encodes a peroxisomal ATP-binding cassette transporter (ABCD1) responsible for transport of CoA-activated very long-chain fatty acids (VLCFA) into the peroxisome for degradation. We used recombinant adenoassociated virus serotype 9 (rAAV9) vector for delivery of the human ABCD1 gene (ABCD1) to mouse central nervous system (CNS). In vitro, efficient delivery of ABCD1 gene was achieved in primary mixed brain glial cells from Abcd1−/− mice as well as X-ALD patient fibroblasts. Importantly, human ABCD1 localized to the peroxisome, and AAV-ABCD1 transduction showed a dose-dependent effect in reducing VLCFA. In vivo, AAV9-ABCD1 was delivered to Abcd1−/− mouse CNS by either stereotactic intracerebroventricular (ICV) or intravenous (IV) injections. Astrocytes, microglia and neurons were the major target cell types following ICV injection, while IV injection also delivered to microvascular endothelial cells and oligodendrocytes. IV injection also yielded high transduction of the adrenal gland. Importantly, IV injection of AAV9-ABCD1 reduced VLCFA in mouse brain and spinal cord. We conclude that AAV9-mediated ABCD1 gene transfer is able to reach target cells in the nervous system and adrenal gland as well as reduce VLCFA in culture and a mouse model of X-ALD. 相似文献
4.
5.
6.
7.
8.
Marshall A. Dalton Cornelia McCormick Flavia De Luca Ian A. Clark Eleanor A. Maguire 《Hippocampus》2019,29(11):1049-1062
While age‐related volumetric changes in human hippocampal subfields have been reported, little is known about patterns of subfield functional connectivity (FC) in the context of healthy ageing. Here we investigated age‐related changes in patterns of FC down the anterior–posterior axis of each subfield. Using high resolution structural MRI we delineated the dentate gyrus (DG), CA fields (including separating DG from CA3), the subiculum, pre/parasubiculum, and the uncus in healthy young and older adults. We then used high resolution resting state functional MRI to measure FC in each group and to directly compare them. We first examined the FC of each subfield in its entirety, in terms of FC with other subfields and with neighboring cortical regions, namely, entorhinal, perirhinal, posterior parahippocampal, and retrosplenial cortices. Next, we analyzed subfield to subfield FC within different portions along the hippocampal anterior–posterior axis, and FC of each subfield portion with the neighboring cortical regions of interest. In general, the FC of the older adults was similar to that observed in the younger adults. We found that, as in the young group, the older group displayed intrinsic FC between the subfields that aligned with the tri‐synaptic circuit but also extended beyond it, and that FC between the subfields and neighboring cortical areas differed markedly along the anterior–posterior axis of each subfield. We observed only one significant difference between the young and older groups. Compared to the young group, the older participants had significantly reduced FC between the anterior CA1‐subiculum transition region and the transentorhinal cortex, two brain regions known to be disproportionately affected during the early stages of age‐related tau accumulation. Overall, these results contribute to ongoing efforts to characterize human hippocampal subfield connectivity, with implications for understanding hippocampal function and its modulation in the ageing brain. 相似文献
9.
10.