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Daniela S. Camilo Fernando Pradella Maria Fernanda Paulino Emilio C. E. Baracat Sofia H. Marini Gil Guerra Elizabeth J. Pavin Candida Parisi Ana Leda F. Longhini Silvia B. Marques Edilaine G. Guariento Sofia R. Lieber Carlos Fernando Macedo Letícia Gama e Silva Alessandro S. Farias Leonilda M. B. Santos Walkyria M. G. Volpini 《Pediatric diabetes》2020,21(4):606-614
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High resolution muscle measurements provide insights into equinus contractures in patients with cerebral palsy 下载免费PDF全文
Margie A. Mathewson Samuel R. Ward Henry G. Chambers Richard L. Lieber 《Journal of orthopaedic research》2015,33(1):33-39
Muscle contractures that occur after upper motor neuron lesion are often surgically released or lengthened. However, surgical manipulation of muscle length changes a muscle's sarcomere length (Ls), which can affect force production. To predict effects of surgery, both macro‐ (fascicle length (Lf)) and micro‐ (Ls) level structural measurements are needed. Therefore, the purpose of this study was to quantify both Ls and Lf in patients with cerebral palsy (CP) as well as typically developing (TD) children. Soleus ultrasound images were obtained from children with CP and TD children. Lf was determined and, with the joint in the same position, CP biopsies were obtained and formalin fixed, and Ls was measured by laser diffraction. Since soleus Ls values were not measurable in TD children, TD Ls values were obtained using three independent methods. While average Lf did not differ between groups (CP = 3.6 ± 1.2 cm, TD = 3.5 ± 0.9 cm; p > 0.6), Ls was dramatically longer in children with CP (4.07 ± 0.45 µm vs. TD = 2.17 ± 0.24 µm; p < 0.0001). While Lf values were similar between children with CP and TD children, this was due to highly stretched sarcomeres within the soleus muscle. Surgical manipulation of muscle‐tendon unit length will thus alter muscle sarcomere length and change force generating capacity of the muscle. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:33–39, 2015. 相似文献
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Sarah B. Lieber Mary Louise Fowler Clara Zhu Andrew Moore Robert H. Shmerling Ziv Paz 《Joint, bone, spine : revue du rhumatisme》2018,85(4):469-473
Objectives
Septic polyarthritis is rarer than septic monoarthritis, but associated with higher mortality. Septic polyarthritis may be difficult to distinguish clinically from noninfectious inflammatory arthritis. We describe one of the largest samples of septic polyarthritis with the aim of distinguishing septic monoarthritis from polyarthritis.Methods
We conducted a retrospective study of adults admitted to tertiary care with septic monoarthritis and polyarthritis. Baseline characteristics, microbial profiles, joint involvement, length of stay, and 60-day readmission rates were determined.Results
We identified 464 and 42 cases of septic monoarthritis and polyarthritis, respectively, including 7 cases of septic polyarthritis with comorbid rheumatoid arthritis. Compared to those with septic monoarthritis, patients with septic polyarthritis were more likely to have rheumatoid arthritis (P < 0.01), sepsis (P < 0.01), and higher peripheral (P < 0.001) and synovial (P < 0.001) white blood cell counts. Operative intervention rates were similar, but mean length of stay was longer in polyarticular septic arthritis (P < 0.001). Patients with septic polyarthritis with/without underlying rheumatoid arthritis were similar in terms of presenting features and outcomes, except for more frequent immunosuppressive therapy in rheumatoid arthritis (P < 0.01).Conclusions
In this sample of patients with septic arthritis, patients with septic polyarthritis were more likely to have systemic infection at presentation than those with septic monoarthritis. Despite this difference, patients with septic monoarthritis and polyarthritis tended to have similar outcomes. While rheumatoid arthritis was observed more frequently among patients with septic polyarthritis, those with/without underlying rheumatoid arthritis had similar presenting features and outcomes. 相似文献10.
Hao-Chun Hu Chin-Lung Kuo Tao-Hsin Tung Szu-Chi Chen Lieber Po-Hung LI 《Journal of the Chinese Medical Association》2018,81(9):837-841