全文获取类型
收费全文 | 4407篇 |
免费 | 224篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 125篇 |
儿科学 | 68篇 |
妇产科学 | 97篇 |
基础医学 | 519篇 |
口腔科学 | 128篇 |
临床医学 | 320篇 |
内科学 | 1156篇 |
皮肤病学 | 15篇 |
神经病学 | 230篇 |
特种医学 | 381篇 |
外科学 | 818篇 |
综合类 | 11篇 |
预防医学 | 117篇 |
眼科学 | 66篇 |
药学 | 187篇 |
中国医学 | 1篇 |
肿瘤学 | 408篇 |
出版年
2023年 | 34篇 |
2022年 | 26篇 |
2021年 | 108篇 |
2020年 | 64篇 |
2019年 | 85篇 |
2018年 | 151篇 |
2017年 | 88篇 |
2016年 | 75篇 |
2015年 | 89篇 |
2014年 | 109篇 |
2013年 | 149篇 |
2012年 | 270篇 |
2011年 | 232篇 |
2010年 | 146篇 |
2009年 | 137篇 |
2008年 | 218篇 |
2007年 | 210篇 |
2006年 | 242篇 |
2005年 | 193篇 |
2004年 | 219篇 |
2003年 | 204篇 |
2002年 | 194篇 |
2001年 | 121篇 |
2000年 | 130篇 |
1999年 | 131篇 |
1998年 | 35篇 |
1997年 | 38篇 |
1996年 | 31篇 |
1995年 | 27篇 |
1994年 | 27篇 |
1993年 | 20篇 |
1992年 | 76篇 |
1991年 | 95篇 |
1990年 | 68篇 |
1989年 | 99篇 |
1988年 | 61篇 |
1987年 | 79篇 |
1986年 | 58篇 |
1985年 | 57篇 |
1984年 | 32篇 |
1983年 | 17篇 |
1982年 | 13篇 |
1979年 | 20篇 |
1978年 | 15篇 |
1977年 | 13篇 |
1973年 | 12篇 |
1972年 | 10篇 |
1971年 | 13篇 |
1970年 | 10篇 |
1969年 | 14篇 |
排序方式: 共有4647条查询结果,搜索用时 15 毫秒
1.
Shogo Yamamoto Yutaka Midorikawa Genta Nagae Kenji Tatsuno Hiroki Ueda Mitsuhiko Moriyama Tadatoshi Takayama Hiroyuki Aburatani 《Cancer science》2020,111(2):601-609
Multiple hepatocellular carcinoma (HCC) is divided into two categories: intrahepatic metastasis (IM), which is a true relapse of HCC, and multicentric origin (MO), which is a second primary tumor. Clinical diagnosis of multiple HCC is usually made based on tumor location and/or time to recurrence; however, it is often difficult to distinguish the two types of multiple HCC. Using 41 matched pairs of multiple HCC specimens, we confirmed the accuracy of clinical diagnoses using exome sequence data and investigated the importance of discriminating the type of multiple HCC. Genomic analysis revealed that 18 (43.9%) patients diagnosed as having genomic IM had common mutations in a pair of HCC tumors with the main tumor of these patients being more progressive compared to those with genomic MO. The accuracy of clinical diagnosis based on lobe (Definition 1) and segment (Definition 2) were 68.3% and 78.0%, respectively. Intriguingly, recurrence ≥2 years after initial surgery for 3 patients was IM. The survival of patients with clinical IM was significantly shorter than for those with clinical MO based on both Definition 1 (P = 0.045) and Definition 2 (P = 0.043). However, mean survival was not different between the patients with genomic IM and those with MO (P = 0.364). Taken together, genomic analysis elucidated that liver cancer may spread more extensively and more slowly than previously thought. In addition, distinguishing multiple HCC as IM or MC may have provided biological information but was not of clinical importance with respect to patient prognosis. 相似文献
2.
Kazuma Murata Kenji Endo Takato Aihara Hidekazu Suzuki Yuji Matsuoka Hirosuke Nishimura Taichiro Takamatsu Takuya Kusakabe Asato Maekawa Kengo Yamamoto 《European spine journal》2020,29(3):413-419
DHS is characterized by chin-on-chest deformity and devastatingly impedes activities of daily living in affected individuals. There is a paucity of literature about the pathophysiology of DHS including knowledge about spinal sagittal alignment. We conducted this study to clarify the relationship between cervical sagittal alignment and global sagittal balance in DHS. This is a retrospective radiographic study of a case series of DHS. Forty-one patients with diagnosed DHS were enrolled. Measurements were made using lateral standing radiograph. C2–C7 sagittal vertical axis (SVA) was estimated as 52.0 ± 2.4 mm. Among sagittal parameters, C7–S1 SVA positively correlated with C2–C7 angle (C2–C7 A) (r = 0.33). For the correlations between C7 and S1 SVA and C2–C7 A, both logistic and linear regression models were used to determine the threshold for C2–C7 A value responsible for global sagittal balance. C2–C7 A of − 15.0 and 6.0 were predicted by logistic and linear regression models and were considered responsible for the occurrence of global positive imbalance. Therefore, we divided into two groups, namely, cervical kyphosis group (C type) and diffuse kyphosis group (D type) by median value of C2–C7 A. Enlarged thoracic kyphosis and global positive imbalance were observed in D type compared to C type. C2–C7 A exhibited correlations with cervical balance and also with global balance. There should be various type of thoraco-lumbar alignment in DHS. These slides can be retrieved under Electronic Supplementary Material. 相似文献
3.
Influence of Pulmonary Vascular Reserve on Exercise‐Induced Pulmonary Hypertension in Patients with Systemic Sclerosis 下载免费PDF全文
Kengo Suzuki M.D. Ph.D. Masaki Izumo M.D. Ph.D. Ryo Kamijima M.D. Kei Mizukoshi M.D. Ph.D. Manabu Takai M.D. Keisuke Kida M.D. Ph.D. Kihei Yoneyama M.D. Ph.D. Sachihiko Nobuoka M.D. Ph.D. Hidehiro Yamada M.D. Ph.D. Yoshihiro J. Akashi M.D. Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(3):428-435
4.
Hirokazu Miki Shingen Nakamura Masahiro Oura Hirofumi Hamano Kenji Ikuta Naoto Okada Yasunobu Okamoto Kimiko Sogabe Mamiko Takahashi Masami Iwasa Kengo Udaka Takeshi Harada Kiyoe Kurahashi Shiro Fujii Sumiko Yoshida Kumiko Kagawa Itsuro Endo Ken-ichi Aihara Masahiro Abe 《British journal of haematology》2019,186(2):355-358
5.
6.
7.
8.
Tatsuki Ueda Ayako Kumagai Shoichi Iriguchi Yutaka Yasui Tadayo Miyasaka Kengo Nakagoshi Kazuki Nakane Keigo Saito Mari Takahashi Aki Sasaki Shinsuke Yoshida Naoko Takasu Hiroshi Seno Yasushi Uemura Koji Tamada Tetsuya Nakatsura Shin Kaneko 《Cancer science》2020,111(5):1478-1490
The use of allogeneic, pluripotent stem‐cell‐derived immune cells for cancer immunotherapy has been the subject of recent clinical trials. In Japan, investigator‐initiated clinical trials will soon begin for ovarian cancer treatment using human leukocyte antigen (HLA)‐homozygous‐induced pluripotent stem cell (iPSC)‐derived anti–glypican‐3 (GPC3) chimeric antigen receptor (CAR)‐expressing natural killer/innate lymphoid cells (NK/ILC). Using pluripotent stem cells as the source for allogeneic immune cells facilitates stringent quality control of the final product, in terms of efficacy, safety and producibility. In this paper, we describe our methods for the stable, feeder‐free production of CAR‐expressing NK/ILC cells from CAR‐transduced iPSC with clinically relevant scale and materials. The average number of cells that could be differentiated from 1.8‐3.6 × 106 iPSC within 7 weeks was 1.8‐4.0 × 109. These cells showed stable CD45/CD7/CAR expression, effector functions of cytotoxicity and interferon gamma (IFN‐γ) production against GPC3‐expressing tumor cells. When the CAR‐NK/ILC cells were injected into a GPC3‐positive, ovarian‐tumor‐bearing, immunodeficient mouse model, we observed a significant therapeutic effect that prolonged the survival of the animals. When the cells were injected into immunodeficient mice during non–clinical safety tests, no acute systemic toxicity or tumorigenicity of the final product or residual iPSC was observed. In addition, our test results for the CAR‐NK/ILC cells generated with clinical manufacturing standards are encouraging, and these methods should accelerate the development of allogeneic pluripotent stem cell‐based immune cell cancer therapies. 相似文献
9.