全文获取类型
收费全文 | 2702篇 |
免费 | 204篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 56篇 |
妇产科学 | 59篇 |
基础医学 | 497篇 |
口腔科学 | 52篇 |
临床医学 | 292篇 |
内科学 | 636篇 |
皮肤病学 | 29篇 |
神经病学 | 295篇 |
特种医学 | 40篇 |
外科学 | 301篇 |
综合类 | 4篇 |
预防医学 | 227篇 |
眼科学 | 39篇 |
药学 | 192篇 |
中国医学 | 15篇 |
肿瘤学 | 166篇 |
出版年
2023年 | 22篇 |
2022年 | 17篇 |
2021年 | 96篇 |
2020年 | 57篇 |
2019年 | 75篇 |
2018年 | 103篇 |
2017年 | 69篇 |
2016年 | 71篇 |
2015年 | 81篇 |
2014年 | 100篇 |
2013年 | 150篇 |
2012年 | 253篇 |
2011年 | 262篇 |
2010年 | 154篇 |
2009年 | 106篇 |
2008年 | 205篇 |
2007年 | 210篇 |
2006年 | 209篇 |
2005年 | 182篇 |
2004年 | 144篇 |
2003年 | 160篇 |
2002年 | 127篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 8篇 |
1998年 | 10篇 |
1997年 | 9篇 |
1996年 | 5篇 |
1995年 | 7篇 |
1994年 | 2篇 |
1993年 | 5篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有2919条查询结果,搜索用时 125 毫秒
1.
2.
3.
Pierre Tiberghien Xavier de Lamballerie Pascal Morel Pierre Gallian Karine Lacombe Yazdan Yazdanpanah 《Vox sanguinis》2020,115(6):488-494
Plasma provided by COVID-19 convalescent patients may provide therapeutic relief as the number of COVID-19 cases escalates steeply worldwide. Prior findings in various viral respiratory diseases including SARS-CoV-related pneumonia suggest that convalescent plasma can reduce mortality, although formal proof of efficacy is still lacking. By reducing viral spread early on, such an approach may possibly downplay subsequent immunopathology. Identifying, collecting, qualifying and preparing plasma from convalescent patients with adequate SARS-CoV-2-neutralizing Ab titres in an acute crisis setting may be challenging, although well within the remit of most blood establishments. Careful clinical evaluation should allow to quickly establish whether such passive immunotherapy, administered at early phases of the disease in patients at high risk of deleterious evolution, may reduce the frequency of patient deterioration, and thereby COVID-19 mortality. 相似文献
4.
5.
Biorevitalizing effect of a novel facial serum containing apple stem cell extract,pro‐collagen lipopeptide,creatine, and urea on skin aging signs 下载免费PDF全文
6.
Annie Leprêtre Idrissa Ba Karine Lacombe Maryvonne Maynart Abdalla Toufik Ousseynou Ndiaye Coumba Toure Kane Joël Gozlan Judicaël Tine Ibrahim Ndoye Gilles Raguin Pierre‐Marie Girard 《Journal of the International AIDS Society》2015,18(1)
Objectives
Data on the extent of drug use and associated HIV, hepatitis C and hepatitis B infection in West Africa are lacking. The objectives of ANRS12244 UDSEN study were to estimate the size of the heroin and/or cocaine drug user (DU) population living in the Dakar area (Senegal), and assess the prevalence and risk factors of HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV), including behavioural determinants in this population, in order to set up an integrated prevention and treatment programme for DUs.Design and methods
A capture-recapture method was applied for population size estimation, whereas the respondent-driven sampling (RDS) method was used to recruit a sample of DUs living in the Dakar area and determine HIV, HBV and HCV prevalence. Behavioural data were gathered during face-to-face interviews, and blood samples were collected on dried blood spots for analysis in a central laboratory. Data analysis was performed using the RDS analysis tool, and risk factors were determined by logistic regression. Access to laboratory results was organized for the participants.Results
The size of the DU population in the Dakar area was estimated to reach 1324 (95% confidence interval (95% CI: 1281–1367)). Based on the 506 DUs included in the study, the HIV, HCV and HBV prevalence were 5.2% (95% CI: 3.8–6.3), 23.3% (95% CI: 21.2–25.2) and 7.9% (95% CI: 5.2–11.1), respectively. In people who inject drugs (PWID), prevalence levels increased to 9.4% for HIV and 38.9% for HCV (p=0.001 when compared to those who never injected). Women were more at risk of being HIV infected (prevalence: 13.04% versus 2.97% in males, p=0.001). Being PWID was a risk factor for HCV and HIV infection (odds ratio, OR: 2.7, 95% CI: 1.7–4.3, and OR: 4.3, 95% CI: 1.7–10.7, respectively), whereas older age and female sex were additional risk factors for HIV infection (10% increase per year of age, p=0.03 and OR: 4.9, 95% CI: 1.6–156, respectively). No specific determinant was associated with the risk of HBV infection.Conclusions
High HIV and HCV prevalence were estimated in this population of DUs (including non-injectors) living in the Dakar area, Senegal, whereas HBV prevalence was close to that of the global Senegalese population, reflecting a risk of infection independent of drug use. Women seem to be highly vulnerable and deserve targeted interventions for decreasing exposure to HIV, while behavioural risk factors for HIV and HCV include the use of unsafe injections, reflecting the urgent need for developing harm reduction interventions and access to opioid substitution therapy services. 相似文献7.
José Albuquerque de Figueiredo Neto Lívia Mariane Castelo Branco Reis Márcia Rodrigues Veras Lorena Lauren Chaves Queiroz Karine de Paiva Lima Nogueira Nunes Priscylla de Oliveira Miranda Alexsandro Ferreira dos Santos Joana Kátya Veras Rodrigues Sampaio Nunes 《Brazilian Journal Of Cardiovascular Surgery》2015,30(6):626-630
INTRODUCTION
The elderly population is growing rapidly. Political and socio-economic changes led to the demographic transition in this population with the highest number of surgeries and as well as many comorbidities.OBJECTIVE
To evaluate the impact of cardiovascular intervention on quality of life of elderly patients after three and six months.METHODS
Analytical prospective cohort study with elderly between 60 and 80 years of age, of both sexes, with a diagnosis of coronary artery disease and underwent cardiovascular intervention during the period June 2010 to June 2011. Data were collected by individual interviews in the pre and postoperative periods (after three and six months) by telephone. We used the SF-36 to analyse quality of life in order to assess the physical and mental health of the study population.RESULTS
Of the 44 individuals evaluated, 59.1% were men, 75% in the range of 65 to 74 years, 38.6% were white and 38.6% were black, 31.8% were uneducated, 43.2% were married and 68.2% had less than a minimum wage. Prevailed patients: non-diabetics (68.2%), non-obese (81.8%), hypertensive (84.1%), non-alcoholic and non-smokers (68.2% and 61.4%, respectively). A significant increase in the average of the SF-36 scores between pre and post-surgical periods (three and six months) for the domains: functional capacity, pain, general health, vitality and emotional aspect.CONCLUSION
The elderly population undergoing intervention may have cardiovascular benefits and improvements of quality of life. Physical fitness improvement measures can be taken to resume that capability. 相似文献8.
9.
10.