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排序方式: 共有473条查询结果,搜索用时 15 毫秒
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Magdalena Kraft Macarena Pia Knop Jean-Marie Renaudin Kathrin Scherer Hofmeier Claudia Pföhler Maria Beatrice Bilò Roland Lang Regina Treudler Nicola Wagner Thomas Spindler Jonathan O'B Hourihane Ioana Maris Alice Koehli Andrea Bauer Lars Lange Sabine Müller Nikolaos G. Papadopoulos Bettina Wedi Anne Moeser Luis F. Ensina Montserrat Fernandez-Rivas Ewa Cichocka-Jarosz George Christoff Blanca E. Garcia Iwona Poziomkowska-Gęsicka Victoria Cardona Tihomir B. Mustakov Uta Rabe Vera Mahler Linus Grabenhenrich Sabine Dölle-Bierke Margitta Worm The Network for Online Registration of Anaphylaxis 《Allergy》2020,75(4):901-910
3.
Philippe A. Eigenmann Motohiro Ebisawa Matthew Greenhawt Jonathan O’B Hourihane Tamara T. Perry Benjamin C. Remington Robert A. Wood 《Pediatric allergy and immunology》2021,32(4):658-666
Risk is a concept inherent in every medical procedure. It can be defined as the probability of an adverse event in a defined population over a specified period of time. In the frame of food allergy management, it might be related to a diagnostic procedure, a treatment, or the consumption of foods. The risk of an adverse event can also be augmented by individual factors. This rostrum article discusses various aspects faced by children with food allergies in the light of risk, and their practical implications. Identifying personal risks for severe reaction, such as unstable asthma, and correcting them whenever possible also contribute to a reduction of the risk inherent to food allergy. Among the facets discussed, oral food challenges (OFC) are the most common diagnostic procedures implying an inherent risk. The risk of OFCs can be minimized by correct indication and timing of the test, a safe setting, as well as by ensuring that the patient is otherwise well without potential stressor potentially increasing the risk of a more severe reaction. Oral immunotherapy (OIT) has been studied as a potential treatment for increasing the threshold dose for reaction, and thus reducing the risk of accidental reaction. Nevertheless, the procedure is not devoid of risk as the patients may and do often react during the course of the procedure. Ingestion of trace amounts in processed foods, mainly in community settings such as restaurants, schools, or day care, represents a potential risk of reactions, although for a minority of patients. Precautionary allergen labeling (PAL) is a widespread strategy to reduce the potential risk of reactions due to traces. However, PAL is currently inefficient due to inconsistent labeling, also not indicating a clear maximum amount possibly present in the manufactured food. Finally, cost-effectiveness needs to be considered in risk management, as many risk reduction procedures are clearly not cost-effective. 相似文献
4.
Ioana Maris Sabine Dölle-Bierke Jean-Marie Renaudin Lars Lange Alice Koehli Thomas Spindler Jonathan Hourihane Kathrin Scherer Katja Nemat C. Kemen Irena Neustädter Christian Vogelberg Thomas Reese Ismail Yildiz Zsolt Szepfalusi Hagen Ott Helen Straube Nikolaos G. Papadopoulos Susanne Hämmerling Ute Staden Michael Polz Tihomir Mustakov Ewa Cichocka-Jarosz Renata Cocco Alessandro Giovanni Fiocchi Montserrat Fernandez-Rivas Margitta Worm Network for Online Registration of Anaphylaxis 《Allergy》2021,76(5):1517-1527
Background
Peanut allergy has a rising prevalence in high-income countries, affecting 0.5%–1.4% of children. This study aimed to better understand peanut anaphylaxis in comparison to anaphylaxis to other food triggers in European children and adolescents.Methods
Data was sourced from the European Anaphylaxis Registry via an online questionnaire, after in-depth review of food-induced anaphylaxis cases in a tertiary paediatric allergy centre.Results
3514 cases of food anaphylaxis were reported between July 2007 - March 2018, 56% in patients younger than 18 years. Peanut anaphylaxis was recorded in 459 children and adolescents (85% of all peanut anaphylaxis cases). Previous reactions (42% vs. 38%; p = .001), asthma comorbidity (47% vs. 35%; p < .001), relevant cofactors (29% vs. 22%; p = .004) and biphasic reactions (10% vs. 4%; p = .001) were more commonly reported in peanut anaphylaxis. Most cases were labelled as severe anaphylaxis (Ring&Messmer grade III 65% vs. 56% and grade IV 1.1% vs. 0.9%; p = .001). Self-administration of intramuscular adrenaline was low (17% vs. 15%), professional adrenaline administration was higher in non-peanut food anaphylaxis (34% vs. 26%; p = .003). Hospitalization was higher for peanut anaphylaxis (67% vs. 54%; p = .004).Conclusions
The European Anaphylaxis Registry data confirmed peanut as one of the major causes of severe, potentially life-threatening allergic reactions in European children, with some characteristic features e.g., presence of asthma comorbidity and increased rate of biphasic reactions. Usage of intramuscular adrenaline as first-line treatment is low and needs to be improved. The Registry, designed as the largest database on anaphylaxis, allows continuous assessment of this condition.5.
Susan Waserman Heather Cruickshank Kyla J. Hildebrand Douglas Mack Laura Bantock Theresa Bingemann Derek K. Chu Carlos Cuello-Garcia Motohiro Ebisawa David Fahmy David M. Fleischer Lisa Galloway Greg Gartrell Matthew Greenhawt Nicola Hamilton Jonathan Hourihane Michael Langlois Richard Loh Jan L. Brozek 《The Journal of allergy and clinical immunology》2021,147(5):1561-1578
6.
Physician's appraisal vs documented signs and symptoms in the interpretation of food challenge tests: The EuroPrevall birth cohort 下载免费PDF全文
Linus B. Grabenhenrich Andreas Reich Doreen McBride Aline Sprikkelman Graham Roberts Kate E. C. Grimshaw Alessandro G. Fiocchi Photini Saxoni‐Papageorgiou Nikolaos G. Papadopoulos Ana Fiandor Santiago Quirce Marek L. Kowalski Sigurveig T. Sigurdardottir Ruta Dubakiene Jonathan O. B. Hourihane Leonard Rosenfeld Bodo Niggemann Thomas Keil Kirsten Beyer 《Pediatric allergy and immunology》2018,29(1):58-65
7.
How does dose impact on the severity of food‐induced allergic reactions,and can this improve risk assessment for allergenic foods? 下载免费PDF全文
A. E. J. Dubois P. J. Turner J. Hourihane B. Ballmer‐Weber K. Beyer C.‐H. Chan M. H. Gowland S. O'Hagan L. Regent B. Remington S. Schnadt T. Stroheker R. W. R. Crevel 《Allergy》2018,73(7):1383-1392
Quantitative risk assessment (QRA) for food allergens has made considerable progress in recent years, yet acceptability of its outcomes remains stymied because of the limited extent to which it has been possible to incorporate severity as a variable. Reaction severity, particularly following accidental exposure, depends on multiple factors, related to the allergen, the host and any treatments, which might be administered. Some of these factors are plausibly still unknown. Quantitative risk assessment shows that limiting exposure through control of dose reduces the rates of reactions in allergic populations, but its impact on the relative frequency of severe reactions at different doses is unclear. Food challenge studies suggest that the relationship between dose of allergenic food and reaction severity is complex even under relatively controlled conditions. Because of these complexities, epidemiological studies provide very limited insight into this aspect of the dose‐response relationship. Emerging data from single‐dose challenges suggest that graded food challenges may overestimate the rate of severe reactions. It may be necessary to generate new data (such as those from single‐dose challenges) to reliably identify the effect of dose on severity for use in QRA. Success will reduce uncertainty in the susceptible population and improve consumer choice. 相似文献
8.
Joseph J Eron David A Cooper Roy T Steigbigel Bonaventura Clotet Jose M Gatell Princy N Kumar Jurgen K Rockstroh Mauro Schechter Martin Markowitz Patrick Yeni Mona R Loutfy Adriano Lazzarin Jeffrey L Lennox Kim M Strohmaier Hong Wan Richard JO Barnard Bach-Yen T Nguyen Hedy Teppler 《The Lancet infectious diseases》2013,13(7):587-596
9.
Peanut allergy (PNA) is the main cause of food-induced anaphylaxis. Severe allergic reactions are more likely to occur in older patients and those with underlying asthma. Skin prick testing and measuring serum-specific IgE and recombinant peanut protein levels have been shown to be useful in the diagnosis of PNA and prediction of reactivity, but these tests are less consistent and reliable in terms of predicting the severity of reactions. Recent research has examined the role of biological mediators in allergic reactions such as platelet-activating factor. These may provide a future tool in predicting those at risk of severe reactions. Currently, there are no parameters that can predict with certainty those at risk of anaphylaxis, and management of PNA should continue to focus on patient and family education. 相似文献
10.
David M. Fleischer Scott Sicherer Matthew Greenhawt Dianne Campbell Edmond Chan Antonella Muraro Susanne Halken Yitzhak Katz Motohiro Ebisawa Lawrence Eichenfield Hugh Sampson Gideon Lack George Du Toit Graham Roberts Henry Bahnson Mary Feeney Jonathan Hourihane Jonathan Spergel Michael Young Amal As'aad Katrina Allen Susan Prescott Sandeep Kapur Hirohisa Saito Ioana Agache Cezmi A. Akdis Hasan Arshad Kirsten Beyer Anthony Dubois Philippe Eigenmann Monserrat Fernandez‐Rivas Kate Grimshaw Karin Hoffman‐Sommergruber Arne Host Susanne Lau Liam O'Mahony Clare Mills Nikolaus Papadopoulos Carina Venter Nancy Agmon‐Levin Aaron Kessel Richard Antaya Beth Drolet Lanny Rosenwasser 《Pediatric dermatology》2016,33(1):103-106
The purpose of this brief communication is to highlight emerging evidence regarding potential benefits of supporting early rather than delayed peanut introduction during the period of complementary food introduction in infants. This document should be considered as interim guidance based on consensus among the following organizations: American Academy of Allergy, Asthma, and Immunology, American Academy of Pediatrics, American College of Allergy, Asthma, and Immunology, Australasian Society of Clinical Immunology and Allergy, Canadian Society of Allergy and Clinical Immunology, European Academy of Allergy and Clinical Immunology, Israel Association of Allergy and Clinical Immunology, Japanese Society for Allergology, Society for Pediatric Dermatology, and World Allergy Organization. More formal guidelines regarding early‐life, complementary feeding practices and the risk of allergy development will follow in the next year from the National Institute of Allergy and Infectious Diseases—sponsored Working Group and the European Academy of Allergy and Clinical Immunology. 相似文献