全文获取类型
收费全文 | 282篇 |
免费 | 37篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 8篇 |
妇产科学 | 5篇 |
基础医学 | 42篇 |
口腔科学 | 1篇 |
临床医学 | 29篇 |
内科学 | 36篇 |
皮肤病学 | 3篇 |
神经病学 | 21篇 |
特种医学 | 3篇 |
外科学 | 51篇 |
综合类 | 2篇 |
预防医学 | 78篇 |
眼科学 | 2篇 |
药学 | 11篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 4篇 |
2021年 | 12篇 |
2020年 | 16篇 |
2019年 | 13篇 |
2018年 | 7篇 |
2017年 | 10篇 |
2016年 | 11篇 |
2015年 | 10篇 |
2014年 | 18篇 |
2013年 | 18篇 |
2012年 | 24篇 |
2011年 | 23篇 |
2010年 | 11篇 |
2009年 | 11篇 |
2008年 | 21篇 |
2007年 | 17篇 |
2006年 | 13篇 |
2005年 | 22篇 |
2004年 | 24篇 |
2003年 | 15篇 |
2002年 | 13篇 |
2001年 | 1篇 |
1998年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
排序方式: 共有320条查询结果,搜索用时 93 毫秒
1.
2.
Samuel M. Goldman MD MPH Freya Kamel PhD G. Webster Ross MD Sarah A. Jewell MD MPH Connie Marras MD PhD Jane A. Hoppin ScD David M. Umbach PhD Grace S. Bhudhikanok PhD Cheryl Meng MS Monica Korell MPH Kathleen Comyns MPH Robert A. Hauser MD Joseph Jankovic MD Stewart A. Factor DO Susan Bressman MD Kelly E. Lyons PhD Dale P. Sandler PhD J. William Langston MD Caroline M. Tanner MD PhD 《Movement disorders》2014,29(9):1171-1180
Increased gut permeability, inflammation, and colonic α‐synuclein pathology are present in early Parkinson's disease (PD) and have been proposed to contribute to PD pathogenesis. Peptidoglycan is a structural component of the bacterial cell wall. Peptidoglycan recognition proteins (PGRPs) maintain healthy gut microbial flora by regulating the immune response to both commensal and harmful bacteria. We tested the hypothesis that variants in genes that encode PGRPs are associated with PD risk. Participants in two independent case‐control studies were genotyped for 30 single‐nucleotide polymorphisms (SNPs) in the four PGLYRP genes. Using logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for potential confounding variables, we conducted analyses in each study, separately and pooled. One SNP failed the assay, and three had little to no variation. The ORs were similar in both study populations. In pooled analyses, three of seven PGLYRP2 SNPs (rs3813135, rs733731, rs892145), one of five PGLYRP3 SNPs (rs2987763), and six of nine PGLYRP4 SNPs (rs10888557, rs12063091, rs3006440, rs3006448, rs3006458, and rs3014864) were significantly associated with PD risk. Association was strongest for PGLYRP4 5'untranslated region (UTR) SNP rs10888557 (GG reference, CG OR 0.6 [95%CI 0.4‐0.9], CC OR 0.15 [95%CI 0.04‐0.6]; log‐additive P‐trend, 0.0004). Common variants in PGLYRP genes are associated with PD risk in two independent studies. These results require replication, but they are consistent with hypotheses of a causative role for the gut microbiota and gastrointestinal immune response in PD. © 2014 International Parkinson and Movement Disorder Society 相似文献
3.
Greetje A. P. Renders Jenny A. F. Vermeer Pui-Ming Leung Freya Reynaert Carla Prins Geerling E. J. Langenbach Vincent Everts 《Calcified tissue international》2014,95(5):436-445
Bisphosphonates are bone antiresorptive agents traditionally used on a relatively large scale for treatment of bone metabolic diseases and on a smaller scale for bone metastasis treatment. A study on the effects of bisphosphonate treatment on healthy instead of diseased animals will give more insight into the basic mechanisms of bisphosphonates and their effects on different bone sites. We aimed to assess the effect of BP on the mouse knee and jaw joint. Three-month old female C57BL/6 mice were used (twenty-four and eighteen control and experimental group, respectively). At baseline and after treatment with zoledronic acid (ZA) for one, three or six months, we combined bone assessment via µCT and additional histology. Our results showed that, in the knee joint, ZA treatment increased TMD, bone volume, trabecular thickness but did not influence cortical thickness. In both control and ZA group, a higher trabecular TMD compared to cortical TMD was seen. Unseen in the knee joint, ZA treatment in the jaw joint resulted in bone-site specific changes in mineralization; a significant time-dependent higher TMD was evident in the subchondral bone compared to the most distal region of the condyle. MicroCT images revealed the presence of mineral in this region and histology showed that this region did not contain mature bone tissue but cartilage-like tissue. Our data indicate the possibility of site-specific negative side effects, i.e., disturbing normal mandibular development under the influence of bisphosphonate therapy. 相似文献
4.
Freya Goodhew Miranda Van Hooff Anthony Sparnon Rachel Roberts Jenelle Baur Elizabeth J. Saccone Alexander McFarlane 《Burns : journal of the International Society for Burn Injuries》2014
Background
Research on the adult psychiatric outcomes of childhood burns is limited.Aims
To examine the rates of DSM-IV psychiatric disorder amongst adult survivors of paediatric burns, and to explore factors likely to contribute to variation in outcomes. In line with Meyer and colleagues [1], it was expected that high levels of psychopathology would be found.Method
Participants were 272 adults hospitalised for burns during childhood between the years 1980 and 1990. Structured interviews and self-report questionnaires were used to assess psychiatric symptoms.Results
Lifetime prevalence of any DSM-IV disorder was 42%, 30% for depressive disorders, and 28% for anxiety disorders. Eleven percent had made a suicide attempt. Female gender, single relationship status, higher level of disfigurement, longer hospital stays and higher number of burn-related surgeries were associated with adverse psychiatric outcomes.Conclusions
High rates of suicidality and depression were concerning in adults with a history of childhood burns. Factors found to predict psychiatric outcomes could be used to direct interventions and further research is needed to establish how this could best be done. 相似文献5.
Freya Tyrer Catherine W. McGrother Catherine F. Thorp Nicholas A. Taub Sabyasachi Bhaumik Domenic V. Cicchetti 《Journal of Applied Research in Intellectual Disabilities》2008,21(3):268-276
Background It is often useful to ascertain whether adults have moderate to profound intellectual disability (approximate IQ < 50; developmental age <108 months) when deciding whether to refer to specialist or mainstream services. The aim of the present study was to develop a simple measure to estimate moderate to profound intellectual disability in adults with a potential need for specialist care. Materials and Methods Three hundred and twenty‐two individuals with information on home interviews from the Leicestershire Learning Disability Register were also assessed using the Vineland Adaptive Behaviour Scales. A variety of variables concerning intelligence, adaptive functioning and dependency were used to predict developmental age (as estimated from the Vineland) using backward stepwise regression. The derived equation formed the Leicestershire Intellectual Disability (LID) tool. A cut‐off point was chosen using a receiver operator characteristic (ROC) curve to achieve 95% sensitivity in identifying moderate to profound intellectual disability. Results Seven variables from the home interviews were found to predict estimated developmental age at the 10% level (P ≤ 0.1). When the tool was used to detect adults with moderate to profound intellectual disability, the area under the ROC curve was 0.93. The chosen cut‐off point was 95% sensitive and 65% specific. The positive predictive value was 95%, the negative predictive value was 65%, and the overall diagnostic accuracy was 91%. Conclusions These preliminary findings suggest that the LID tool may help to identify adults with moderate to profound intellectual disability among those with potential need for specialist care. Further evaluation is recommended. 相似文献
6.
7.
8.
9.
10.
High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study 下载免费PDF全文