全文获取类型
收费全文 | 6616篇 |
免费 | 407篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 141篇 |
儿科学 | 203篇 |
妇产科学 | 67篇 |
基础医学 | 802篇 |
口腔科学 | 79篇 |
临床医学 | 617篇 |
内科学 | 1828篇 |
皮肤病学 | 91篇 |
神经病学 | 576篇 |
特种医学 | 228篇 |
外国民族医学 | 7篇 |
外科学 | 1126篇 |
综合类 | 36篇 |
预防医学 | 350篇 |
眼科学 | 63篇 |
药学 | 411篇 |
中国医学 | 5篇 |
肿瘤学 | 432篇 |
出版年
2023年 | 35篇 |
2022年 | 30篇 |
2021年 | 123篇 |
2020年 | 74篇 |
2019年 | 134篇 |
2018年 | 175篇 |
2017年 | 119篇 |
2016年 | 136篇 |
2015年 | 172篇 |
2014年 | 215篇 |
2013年 | 279篇 |
2012年 | 438篇 |
2011年 | 432篇 |
2010年 | 228篇 |
2009年 | 232篇 |
2008年 | 367篇 |
2007年 | 364篇 |
2006年 | 422篇 |
2005年 | 383篇 |
2004年 | 327篇 |
2003年 | 340篇 |
2002年 | 304篇 |
2001年 | 129篇 |
2000年 | 136篇 |
1999年 | 118篇 |
1998年 | 69篇 |
1997年 | 45篇 |
1996年 | 45篇 |
1995年 | 39篇 |
1994年 | 38篇 |
1993年 | 35篇 |
1992年 | 97篇 |
1991年 | 86篇 |
1990年 | 64篇 |
1989年 | 72篇 |
1988年 | 54篇 |
1987年 | 83篇 |
1986年 | 62篇 |
1985年 | 69篇 |
1984年 | 42篇 |
1983年 | 43篇 |
1982年 | 24篇 |
1981年 | 22篇 |
1979年 | 45篇 |
1977年 | 21篇 |
1976年 | 24篇 |
1974年 | 28篇 |
1973年 | 27篇 |
1972年 | 21篇 |
1971年 | 34篇 |
排序方式: 共有7062条查询结果,搜索用时 234 毫秒
1.
Lauren E. Barber Kimberly A. Bertrand Shanshan Sheehy Laura F. White Hemant K. Roy Lynn Rosenberg Julie R. Palmer Jessica L. Petrick 《International journal of cancer. Journal international du cancer》2023,153(12):1978-1987
Evidence suggests that aspirin use reduces the occurrence of colorectal neoplasia. Few studies have investigated the association among Black Americans, who are disproportionately burdened by the disease. We assessed aspirin use in relation to colorectal adenoma among Black women. The Black Women's Health Study is a prospective cohort of self-identified Black American women established in 1995. Participants reported regular aspirin use on baseline and follow-up questionnaires. Beginning in 1999, participants reported undergoing a colonoscopy or sigmoidoscopy, the only procedures through which colorectal adenomas can be diagnosed. Multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between aspirin use and colorectal adenoma among 34 397 women who reported at least 1 colonoscopy or sigmoidoscopy. From 1997 through 2018, 1913 women were diagnosed with an adenoma. Compared to nonaspirin users, regular users had 14% (OR = 0.86, 95% CI: 0.78-0.95) lower odds of adenoma. The odds of adenoma decreased with increasing duration of aspirin use (≥10 years: OR = 0.80, 95% CI: 0.66-0.96). Initiating aspirin at a younger age was associated with a reduced adenoma occurrence (age < 40 years at initiation: OR = 0.69, 95% CI: 0.55-0.86). Regular aspirin use was associated with a decreased odds of colorectal adenoma in our study of Black women. These findings support evidence demonstrating a chemopreventive impact of aspirin on colorectal neoplasia and suggest that aspirin may be a useful prevention strategy among US Black women. 相似文献
2.
3.
4.
Aurélie Mailliez Camille Ternynck Alain Duhamel Audrey Mailliez Anne Ploquin Christophe Desauw Madleen Lemaitre Nicolas Bertrand Anne Vambergue Anthony Turpin 《International journal of cancer. Journal international du cancer》2023,152(3):408-416
Diabetes mellitus (DM) is a common comorbidity among cancer patients, but its impact on chemotherapy tolerance has not been widely studied. We aimed to compare the occurrence of severe grade 3/4 adverse events (G3/4 AEs) within 90 days of starting chemotherapy between patients with and without diabetes. We conducted a retrospective single-center study in Lille University Hospital Oncology Department, France. Patients who received the first cycle of chemotherapy for gastrointestinal, gynecological or cancer of unknown primary source between 1 May 2013 and 1 May 2016, were included. Overall, 609 patients were enrolled: 490 patients without diabetes (80.5%) and 119 patients with diabetes (19.5%). Within 90 days of starting chemotherapy, patients with diabetes had a significantly higher occurrence of AEs G3/4 compared to those with no diabetes (multivariate odds ratio [OR]: 1.57 [1.02-2.42], P = .04). More frequent G3/4 AEs in patients with diabetes were infection (26%), hematological disorders (13%), endocrine disorders (13%) and deterioration of the general condition (13%). In the year following the beginning of chemotherapy, patients with diabetes were twice as likely to be hospitalized as those without diabetes (univariate OR: 2.1 [1.40-3.15], P = .0003). After multivariate adjustment, diabetes was no longer significantly associated with the risk of hospitalization (P = .051). There were no differences between patients with and without diabetes regarding dose reduction and chemotherapy treatment delays (P = .61 and P = .30, respectively). Our study suggests the need for better consideration of DM in the personalized care plan to improve chemotherapy tolerance and quality of life of patients with DM. 相似文献
5.
6.
Ly-Thuy-Tram Le Morgane Couvet Bertrand Favier Jean-Luc Coll Chi-Hung Nguyen Annie Molla 《Oncotarget》2015,6(26):22152-22166
Aurora kinases play an essential role in mitotic progression and are attractive targets in cancer therapy. The first generation of benzo[e]pyridoindole exhibited powerful aurora kinase inhibition but their low solubility limited further development. Grafting a pyperidine-ethoxy group gives rise to a hydrosoluble inhibitor: compound C5M.C5M could efficiently inhibit the proliferation of cells from different origins. C5M prevented cell cycling, induced a strong mitotic arrest then, cells became polyploid and finally died. C5M did not impair the spindle checkpoint, the separation of the sister chromatids and the transfer of aurora B on the mid-zone. C5M prevented histone H3 phosphorylation at mitotic entry and erased AMPK-Thr172 phosphorylation in late mitosis. With this unique profile of inhibition, C5M could be useful for understanding the role of phospho-Thr172-AMPK, in abscission and the relationship between the chromosomal complex and the energy sensing machinery.C5M is a multikinase inhibitor with interesting preclinical characteristics: high hydro-solubility and a good stability in plasma. A single dose prevents the expansion of multicellular spheroids. C5M can safely be injected to mice and reduces significantly the development of xenograft. The next step will be to define the protocol of treatment and the cancer therapeutic field of this new anti-proliferative drug. 相似文献
7.
8.
Pieter-Jan Ceyssens Wesley Mattheus Raymond Vanhoof Sophie Bertrand 《Antimicrobial agents and chemotherapy》2015,59(1):544-552
The Belgian National Reference Centre for Salmonella received 16,544 human isolates of Salmonella enterica between January 2009 and December 2013. Although 377 different serotypes were identified, the landscape is dominated by S. enterica serovars Typhimurium (55%) and Enteritidis (19%) in a ratio which is inverse to European Union averages. With outbreaks of Salmonella serotypes Ohio, Stanley, and Paratyphi B variant Java as prime examples, 20 serotypes displayed significant fluctuations in this 5-year period. Typhoid strains account for 1.2% of Belgian salmonellosis cases. Large-scale antibiotic susceptibility analyses (n = 4,561; panel of 12 antibiotics) showed declining resistance levels in S. Enteritis and Typhimurium isolates for 8 and 3 tested agents, respectively. Despite low overall resistance to ciprofloxacin (4.4%) and cefotaxime (1.6%), we identified clonal lineages of Salmonella serotypes Kentucky and Infantis displaying rising resistance against these clinically important drugs. Quinolone resistance is mainly mediated by serotype-specific mutations in GyrA residues Ser83 and Asp87 (92.2% not wild type), while an additional ParC_Ser80Ile mutation leads to ciprofloxacin resistance in 95.5% S. Kentucky isolates, which exceeds European averages. Plasmid-mediated quinolone resistance (PMQR) alleles qnrA1 (n = 1), qnrS (n = 9), qnrD1 (n = 4), and qnrB (n = 4) were found in only 3.0% of 533 isolates resistant to nalidixic acid. In cefotaxime-resistant isolates, we identified a broad range of Ambler class A and C β-lactamase genes (e.g., blaSHV-12, blaTEM-52, blaCTX-M-14, and blaCTX-M-15) commonly associated with members of the family Enterobacteriaceae. In conclusion, resistance to fluoroquinolones and cefotaxime remains rare in human S. enterica, but clonal resistant serotypes arise, and continued (inter)national surveillance is mandatory to understand the origin and routes of dissemination thereof. 相似文献
9.
Jesse Mez MD MS Daniel H. Daneshvar MD PhD Bobak Abdolmohammadi BA Alicia S. Chua MS Michael L. Alosco PhD Patrick T. Kiernan BA Laney Evers BA Laura Marshall BA Brett M. Martin MS Joseph N. Palmisano MS Christopher J. Nowinski PhD Ian Mahar PhD Jonathan D. Cherry PhD Victor E. Alvarez MD Brigid Dwyer MD Bertrand R. Huber MD PhD Thor D. Stein MD PhD Lee E. Goldstein MD PhD Douglas I. Katz MD Robert C. Cantu MD Rhoda Au PhD Neil W. Kowall MD Robert A. Stern PhD Michael D. McClean MS ScD Jennifer Weuve MPH ScD Yorghos Tripodis PhD Ann C. McKee MD 《Annals of neurology》2020,87(1):116-131