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Luigi Rosati Marisa Agnese Ludovico Abagnale Francesco Aniello Piero Andreuccetti Marina Prisco 《Anatomical record (Hoboken, N.J. : 2007)》2019,302(6):1039-1049
The aim of the present article was to investigate the oogenic cycle of Mytilus galloprovincialis sampled in the Bay of Naples, and to immunolocalize 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β-hydroxysteroid dehydrogenase (17β-HSD), and P450 aromatase, enzymes involved in the synthesis of two sex hormones: testosterone and 17β-estradiol. We demonstrate that the oogenic cycle starts in late summer-early fall and continues in early winter when the first event of spawning occurs; other spawning events take place until June, when the ovary is spent and contains a few empty ovarian follicles and numerous somatic cells, that is, adipogranular cells and vesicular connective tissue cells. During the oogenic cycle, apoptotic events occur at the level of oogonia, previtellogenic oocytes, as well as follicle cells; by contrast, necrosis events probably take place in vitellogenic oocytes, which, once degenerated, transfer their content to healthy oocytes. Finally, the present data demonstrate that 3β-HSD, 17β-HSD, and P450 aromatase are present in the ovary both during the reproductive and nonreproductive phases. The possible role of these enzymes during the Mytilus galloprovincialis reproductive cycle is discussed. Anat Rec, 302:1039–1049, 2019. © 2019 Wiley Periodicals, Inc. 相似文献
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Neide Tomimura Costa Bruna Miglioranza Scavuzzi Tatiana Mayumi Veiga Iriyoda Marcell Alysson Batisti Lozovoy Daniela Frizon Alfieri Fabiano Aparecido de Medeiros Marcelo Cândido de Sá Pâmela Lonardoni Micheletti Bruno Alexandre Sekiguchi Edna Maria Vissoci Reiche Michael Maes Andréa Name Colado Simão Isaias Dichi 《Clinical and experimental medicine》2018,18(3):363-372
Oxidative stress plays a role in the pathophysiology of rheumatoid arthritis (RA). The aim of the present study was to verify the influence of metabolic syndrome (MetS) and disease-modifying antirheumatic drugs on nitrosative and oxidative biomarkers in patients with RA. A total of 177 patients with RA and 150 healthy volunteers participated in this study, which measured lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), carbonyl protein, total radical-trapping antioxidant parameter (TRAP), uric acid (UA), and C-reactive protein (CRP). NOx and the NOx/TRAP ratio were significantly increased in RA, while no significant differences in lipid hydroperoxides, AOPP, UA, and TRAP levels were found between both groups. Treatment with leflunomide was associated with increased levels of carbonyl protein, and lowered levels in TRAP and UA, while the NOx/TRAP ratio further increased. NOx and the NOx/TRAP ratio were significantly higher in women than in men, while TRAP and UA were significantly lower in women. MetS was accompanied by increased AOPP and UA levels. RA was best predicted by increased NOx/TRAP ratio, CRP, and BMI. In conclusion, our data demonstrated that NOx and NOx/TRAP are strongly associated with RA physiopathology. Our findings suggest that inhibition of iNOS may become an interesting therapeutic approach for the treatment of RA. In addition, the presence of MetS and a decrease in levels of UA by leflunomide favor redox imbalance in RA patients. More studies are needed to evaluate the impact of antioxidant capacity reduction on RA progression. 相似文献
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Echocardiographic features of post−transcatheter aortic valve implantation thrombosis and endocarditis 下载免费PDF全文
Marco Spartera MD Francesco Ancona MD Marta Barletta MD Isabella Rosa MD Stefano Stella MD Claudia Marini MD Leonardo Italia MD Matteo Montorfano MD Azeem Latib MD Ottavio Alfieri MD Alberto Margonato MD Antonio Colombo MD Eustachio Agricola MD 《Echocardiography (Mount Kisco, N.Y.)》2018,35(3):337-345
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Sara Bulgheroni Stefano D'Arrigo Sabrina Signorini Marilena Briguglio Maria Lucia Di Sabato Manuela Casarano Francesca Mancini Marta Romani Paolo Alfieri Roberta Battini Marina Zoppello Gaetano Tortorella Enrico Bertini Vincenzo Leuzzi Enza Maria Valente Daria Riva 《American journal of medical genetics. Part A》2016,170(12):3115-3124