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排序方式: 共有6155条查询结果,搜索用时 15 毫秒
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Emad A. Rakha Islam M. Miligy Cecily M. Quinn Elena Provenzano Abeer M. Shaaban Caterina Marchi Michael S. Toss Grace Gallagy Ciara Murray Janice Walshe Ayaka Katayama Karim Eldib Nahla Badr Bruce Tanchel Rebecca Millican-Slater Colin Purdie Dave Purnell Sarah E. Pinder Ian O. Ellis Andrew H. S. Lee 《British journal of cancer》2021,124(11):1836
Background The ASCO/CAP guidance on HER2 testing in breast cancer (BC) has recently changed. Group 2 tumours with immunohistochemistry score 2+ and HER2/CEP17 ratio ≥2.0 and HER2 copy number <4.0 signals/cell were re-classified as HER2 negative. This study aims to examine the response of Group 2 tumours to neoadjuvant chemotherapy (NACT).Methods 749 BC cases were identified from 11 institutions. The association between HER2 groups and pathological complete response (pCR) was assessed.Results 54% of immunohistochemistry HER2 positive (score 3+) BCs showed pCR, compared to 19% of immunohistochemistry 2+ FISH amplified cases. 27% of Group 2 treated with HER2 targeted therapy achieved pCR, compared to 19 and 11% in the combined Groups 1 + 3 and Groups 4 + 5, respectively. No difference in pCR rates was identified between Group 2 and Group 1 or combined Groups 1 + 3. However, Group 2 response rate was higher than Groups 4 + 5 (p = 0.017).Conclusion No difference in pCR was detected in tumours with a HER2/CEP17 ratio ≥2.0 and a HER2 score 2+ by IHC when stratified by HER2 gene copy number. Our data suggest that ASCO/CAP HER2 Group 2 carcinomas should be evaluated further with respect to eligibility for HER2 targeted therapy.Subject terms: Breast cancer, Breast cancer 相似文献
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Katherine Quinn Julia Dickson-Gomez Jeffrey A. Kelly 《Culture, health & sexuality》2016,18(5):524-537
In the USA, the Black Church is among the most important institutions in the Black community, offering numerous spiritual, social and health benefits. Yet, the presence of homonegativity in many Black Churches may mitigate those effects for gay Black youth. This research examines the role of the Church in the lives of gay and bisexual Black youth to understand how they reconcile any tension between their religious and sexual identities. Through interviews with pastors of Black churches (n = 21) and young Black men who have sex with men (n = 30), we explored homonegativity and young men’s experiences within the Black Church. Findings reveal that despite the prevalence of homonegativity within Black churches, religious involvement remains important for young men and many remain involved in non-affirming churches. The importance of the Church for young men stems from their significant involvement as youth and the integration of religion, family and community. Young men may not be able to leave their religious homes as readily as other gay youth given the cultural relevance of the Church. As a result, young men made attempts to conceal their sexuality in church to avoid shame and gossip and find opportunities to balance their sexuality and religiosity. 相似文献
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Sharon Elad Judith E. Raber-Durlacher Michael T. Brennan Deborah P. Saunders Arno P. Mank Yehuda Zadik Barry Quinn Joel B. Epstein Nicole M. A. Blijlevens Tuomas Waltimo Jakob R. Passweg M. Elvira P. Correa Göran Dahllöf Karin U. E. Garming-Legert Richard M. Logan Carin M. J. Potting Michael Y. Shapira Yoshihiko Soga Jacqui Stringer Monique A. Stokman Samuel Vokurka Elisabeth Wallhult Noam Yarom Siri Beier Jensen 《Supportive care in cancer》2015,23(1):223-236
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Eliot L. Rees Patrick J. Quinn Benjamin Davies Victoria Fotheringham 《Medical teacher》2016,38(8):829-837
Purpose: In undergraduate medical education, peer-teaching has become an established and common method to enhance student learning. Evidence suggests that peer-teaching provides learning benefits for both learners and tutors. We aimed to describe the outcomes for medical students taught by peers through systematic review and meta-analysis of existing literature.Methods: Seven databases were searched through 21 terms and their Boolean combinations. Studies reporting knowledge or skills outcomes of students taught by peers compared to those taught by faculty or qualified clinicians were included. Extracted data on students’ knowledge and skills outcomes were synthesised through a random effects model meta-analysis.Results: The search yielded 2292 studies. Five hundred and fifty-three duplicates and 1611 irrelevant articles were removed during title-screening. The abstracts of 128 papers were screened against the inclusion and exclusion criteria. Ten studies have been included in the review. Meta-analyses showed no significant difference in peer-teaching compared to faculty teaching for knowledge or skills outcomes, standardised mean differences were 0.07 (95% CI: ?0.07, 0.21) and 0.11 (95% CI: ?0.07, 1.29), respectively.Conclusion: Students taught by peers do not have significantly different outcomes to those taught by faculty. As the process of teaching helps to develop both tutor knowledge and teaching skills, peer-teaching should be supported. 相似文献
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Sumanta K. Pal MD Dean Bajorin MD Nazli Dizman MD Jean Hoffman-Censits MD David I. Quinn MD Daniel P. Petrylak MD Matthew D. Galsky MD Ulka Vaishampayan MD Ugo De Giorgi MD Sumati Gupta MD Howard A. Burris MD Harris S. Soifer PhD Gary Li PhD Hao Wang PhD Carl L. Dambkowski MD Susan Moran MD Siamak Daneshmand MD Jonathan E. Rosenberg MD 《Cancer》2020,126(11):2597-2606