全文获取类型
收费全文 | 18996篇 |
免费 | 926篇 |
国内免费 | 98篇 |
专业分类
耳鼻咽喉 | 226篇 |
儿科学 | 331篇 |
妇产科学 | 226篇 |
基础医学 | 2462篇 |
口腔科学 | 453篇 |
临床医学 | 1230篇 |
内科学 | 4320篇 |
皮肤病学 | 221篇 |
神经病学 | 1322篇 |
特种医学 | 1303篇 |
外科学 | 3549篇 |
综合类 | 84篇 |
现状与发展 | 1篇 |
预防医学 | 412篇 |
眼科学 | 238篇 |
药学 | 1415篇 |
中国医学 | 23篇 |
肿瘤学 | 2204篇 |
出版年
2023年 | 100篇 |
2022年 | 66篇 |
2021年 | 291篇 |
2020年 | 193篇 |
2019年 | 275篇 |
2018年 | 346篇 |
2017年 | 281篇 |
2016年 | 377篇 |
2015年 | 381篇 |
2014年 | 476篇 |
2013年 | 591篇 |
2012年 | 895篇 |
2011年 | 1026篇 |
2010年 | 630篇 |
2009年 | 571篇 |
2008年 | 949篇 |
2007年 | 1033篇 |
2006年 | 1049篇 |
2005年 | 1069篇 |
2004年 | 1079篇 |
2003年 | 1006篇 |
2002年 | 965篇 |
2001年 | 528篇 |
2000年 | 526篇 |
1999年 | 503篇 |
1998年 | 223篇 |
1997年 | 188篇 |
1996年 | 200篇 |
1995年 | 166篇 |
1994年 | 151篇 |
1993年 | 125篇 |
1992年 | 390篇 |
1991年 | 322篇 |
1990年 | 344篇 |
1989年 | 354篇 |
1988年 | 313篇 |
1987年 | 306篇 |
1986年 | 259篇 |
1985年 | 257篇 |
1984年 | 170篇 |
1983年 | 115篇 |
1982年 | 68篇 |
1981年 | 59篇 |
1980年 | 49篇 |
1979年 | 81篇 |
1978年 | 82篇 |
1977年 | 67篇 |
1974年 | 59篇 |
1972年 | 55篇 |
1970年 | 49篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Harada Hideyuki Omori Shota Mori Keita Konno Masahiro Murakami Haruyasu Imagumbai Toshiyuki Fukuda Haruyuki Nakamatsu Kiyoshi Kimura Tomoki Tanabe Hiroaki Fujita Hideki Tatebe Hitoshi Fujitaka Kazunori Nishimura Yasumasa 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(6):1025-1033
International Journal of Clinical Oncology - This multi-institutional clinical trial evaluated the feasibility of intensity-modulated radiotherapy (IMRT) for patients with locally advanced... 相似文献
2.
3.
4.
5.
Takeshi Nagashima Ken Yamaguchi Kenichi Urakami Yuji Shimoda Sumiko Ohnami Keiichi Ohshima Tomoe Tanabe Akane Naruoka Fukumi Kamada Masakuni Serizawa Keiichi Hatakeyama Kenya Matsumura Shumpei Ohnami Koji Maruyama Tohru Mochizuki Masatoshi Kusuhara Akio Shiomi Yasuhisa Ohde Masanori Terashima Katsuhiko Uesaka Tetsuro Onitsuka Seiichiro Nishimura Yasuyuki Hirashima Nakamasa Hayashi Yoshio Kiyohara Yasuhiro Tsubosa Hirohisa Katagiri Masashi Niwakawa Kaoru Takahashi Hiroya Kashiwagi Masahiro Nakagawa Yuji Ishida Takashi Sugino Mitsuru Takahashi Yasuto Akiyama 《Cancer science》2020,111(2):687-699
This study aimed to establish the Japanese Cancer Genome Atlas (JCGA) using data from fresh frozen tumor tissues obtained from 5143 Japanese cancer patients, including those with colorectal cancer (31.6%), lung cancer (16.5%), gastric cancer (10.8%) and other cancers (41.1%). The results are part of a single‐center study called “High‐tech Omics‐based Patient Evaluation” or “Project HOPE” conducted at the Shizuoka Cancer Center, Japan. All DNA samples and most RNA samples were analyzed using whole‐exome sequencing, cancer gene panel sequencing, fusion gene panel sequencing and microarray gene expression profiling, and the results were annotated using an analysis pipeline termed “Shizuoka Multi‐omics Analysis Protocol” developed in‐house. Somatic driver alterations were identified in 72.2% of samples in 362 genes (average, 2.3 driver events per sample). Actionable information on drugs that is applicable in the current clinical setting was associated with 11.3% of samples. When including those drugs that are used for investigative purposes, actionable information was assigned to 55.0% of samples. Germline analysis revealed pathogenic mutations in hereditary cancer genes in 9.2% of samples, among which 12.2% were confirmed as pathogenic mutations by confirmatory test. Pathogenic mutations associated with non–cancerous hereditary diseases were detected in 0.4% of samples. Tumor mutation burden (TMB) analysis revealed 5.4% of samples as having the hypermutator phenotype (TMB ≥ 20). Clonal hematopoiesis was observed in 8.4% of samples. Thus, the JCGA dataset and the analytical procedures constitute a fundamental resource for genomic medicine for Japanese cancer patients. 相似文献
6.
Kazuma Murata Kenji Endo Takato Aihara Hidekazu Suzuki Yuji Matsuoka Hirosuke Nishimura Taichiro Takamatsu Takuya Kusakabe Asato Maekawa Kengo Yamamoto 《European spine journal》2020,29(3):413-419
DHS is characterized by chin-on-chest deformity and devastatingly impedes activities of daily living in affected individuals. There is a paucity of literature about the pathophysiology of DHS including knowledge about spinal sagittal alignment. We conducted this study to clarify the relationship between cervical sagittal alignment and global sagittal balance in DHS. This is a retrospective radiographic study of a case series of DHS. Forty-one patients with diagnosed DHS were enrolled. Measurements were made using lateral standing radiograph. C2–C7 sagittal vertical axis (SVA) was estimated as 52.0 ± 2.4 mm. Among sagittal parameters, C7–S1 SVA positively correlated with C2–C7 angle (C2–C7 A) (r = 0.33). For the correlations between C7 and S1 SVA and C2–C7 A, both logistic and linear regression models were used to determine the threshold for C2–C7 A value responsible for global sagittal balance. C2–C7 A of − 15.0 and 6.0 were predicted by logistic and linear regression models and were considered responsible for the occurrence of global positive imbalance. Therefore, we divided into two groups, namely, cervical kyphosis group (C type) and diffuse kyphosis group (D type) by median value of C2–C7 A. Enlarged thoracic kyphosis and global positive imbalance were observed in D type compared to C type. C2–C7 A exhibited correlations with cervical balance and also with global balance. There should be various type of thoraco-lumbar alignment in DHS. These slides can be retrieved under Electronic Supplementary Material. 相似文献
7.
8.
Heterozygous nonsense mutations near the C‐terminal region of IGF1R in two patients with small‐for‐gestational‐age‐related short stature 下载免费PDF全文
9.
Yushi Katsuyama Norihisa Taira Tatsuya Tsuboi Masato Yoshioka Yuri Okano Hitoshi Masaki 《Experimental dermatology》2019,28(Z1):64-68
Skin sensitivity is a serious problem for many people, and it can be induced by various factors such as UV irradiation, physical and mental stresses, air pollution, dry air and so on. Skin dryness triggered by UV and dry air is one of the most important causes inducing the development of sensitive skin, and it has been reported that oxidative stress contributes to skin dryness. In this study, we investigated whether treatment with 3‐O‐laurylglyceryl ascorbate (VC‐3LG), which is an amphipathic ascorbic acid derivative, can suppress the development of sensitive skin. The results demonstrate that VC‐3LG restores the expression levels of interleukin‐1α, nerve growth factor and matrix metalloprotease‐9 in the dry skin models of reconstructed human epidermal equivalents (RHEEs) and in H2O2‐treated keratinocytes. In addition, VC‐3LG suppresses the dendrite elongation of nerve cells induced in RHEEs by dry skin conditions and by H2O2 treatment of keratinocytes. Therefore, we consider that treatment of the skin with VC‐3LG is an effective approach to improve the development of sensitive skin. 相似文献