Azithromycin resistance and its molecular characteristics in Neisseria gonorrhoeae isolates from a tertiary care centre in North India

Treatment guidelines for management of uncomplicated gonorrhoeae have been recently modified owing to alarming upsurge in azithromycin resistance. This study investigated the prevalence and genetic determinants of gonococcal azithromycin resistance in India. Four (5.7%) of 70 gonococcal isolates were resistant to azithromycin. Of 16 isolates investigated for molecular mechanisms of resistance, 13 (81.3%) and 6 (37.5%) isolates exhibited mutations in coding and promoter regions of mtrR gene, respectively. However, ermA, ermB and ermC genes or mutations in rrl gene were absent in all isolates. Azithromycin resistance is low in India posing no immediate threat to use of dual-therapy for syndromic management.     

Does ATTRACT change our DVT management practice?

In 2017, the long awaited results of the ATTRACT trial were published in the New England Journal of Medicine leaving the scientific community with disappointment as the study did not show the expected results. Producing not the expected outcome is not uncommon in science – furthermore, it is important to disapprove common beliefs. But has the ATTRACT trial really the power to change our practice? Are the results correct in terms of evidence based on the methods used?

In 2017, the long awaited results of the ATTRACT trial were published in the New England Journal of Medicine^1,2 leaving the scientific community with disappointment as the study did not show the expected results. Producing not the expected outcome is not uncommon in science – furthermore, it is important to disapprove common beliefs. But has the ATTRACT trial really the power to change our practice? Are the results correct in terms of evidence based on the methods used? To understand the results, it is important to analyze the methods of the trial and to discuss them in a broader view.     

The use of cadaver models to diagnose rib fractures: A pilot study

Background

In the emergency department, rib fractures are a common finding in patients who sustain chest trauma. Rib fractures may be a sign of significant, underlying pathology, especially in the elderly patients where rib fractures are associated with significant morbidity and mortality. To date, no studies have evaluated the ability of ultrasound to detect rib fractures using cadaver models and subsequently use this model as a teaching tool.

Author affiliation addition: “Hepatitis B virus detected in paper currencies in a densely populated city of India: A plausible source of horizontal transmission?”

Addition of authors’ affiliation to "Hepatitis B virus detected in paper currencies in a densely populated city of India: A plausible source of horizontal transmission?" World J Hepatol 2020 Oct 27; 12(10): 775-791. In this article, one of the affiliations of two authors was not mentioned. Ruchi Supekar, a joint first author and Subhajit Biswas, the corresponding author are affiliated to Academy of Scientific and Innovative Research (AcSIR) Ghaziabad- 201002, India.     

Pilot Interventional Study Comparing Fetomaternal Outcomes of 150 mg Versus 75 mg Aspirin Starting Between 11 and 14 Weeks of Pregnancy in Patients with High Risk of Preeclampsia: A Randomized Control Trial

The Journal of Obstetrics and Gynecology of India - Hypertensive disorders of pregnancies complicate around 5–10% of pregnancies worldwide, and together they are a member of the deadly triad...     

Repurposing fallen leaves to bio-based reaction medium for hydration,hydroxylation, carbon-carbon and carbon-nitrogen bond formation reactions

A green reaction medium has been developed from the Water Extract of Teak leaf (Tectona grandis) ash (WET). The alkaline nature of the WET was successfully applied towards hydration of nitriles, conversion of arylboronic acids to phenols with 30% aqueous H₂O₂, Knoevenagel condensation for benzylidenemalononitrile derivatives formation and Chan-Lam reaction of arylboronic acids with imidazole derivatives. In current protocols dual role of WET as reaction medium as well as base has been explored. A wide range of substrates with varying electronic natures is compatible under these WET mediated reaction conditions with excellent yields.