全文获取类型
收费全文 | 2908篇 |
免费 | 161篇 |
国内免费 | 52篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 50篇 |
妇产科学 | 16篇 |
基础医学 | 376篇 |
口腔科学 | 26篇 |
临床医学 | 179篇 |
内科学 | 913篇 |
皮肤病学 | 43篇 |
神经病学 | 235篇 |
特种医学 | 125篇 |
外科学 | 491篇 |
综合类 | 14篇 |
预防医学 | 69篇 |
眼科学 | 39篇 |
药学 | 235篇 |
中国医学 | 12篇 |
肿瘤学 | 262篇 |
出版年
2023年 | 38篇 |
2022年 | 15篇 |
2021年 | 77篇 |
2020年 | 45篇 |
2019年 | 66篇 |
2018年 | 73篇 |
2017年 | 72篇 |
2016年 | 68篇 |
2015年 | 67篇 |
2014年 | 93篇 |
2013年 | 123篇 |
2012年 | 190篇 |
2011年 | 199篇 |
2010年 | 92篇 |
2009年 | 84篇 |
2008年 | 178篇 |
2007年 | 217篇 |
2006年 | 175篇 |
2005年 | 214篇 |
2004年 | 193篇 |
2003年 | 186篇 |
2002年 | 200篇 |
2001年 | 55篇 |
2000年 | 46篇 |
1999年 | 35篇 |
1998年 | 33篇 |
1997年 | 23篇 |
1996年 | 20篇 |
1995年 | 42篇 |
1994年 | 17篇 |
1993年 | 11篇 |
1992年 | 21篇 |
1991年 | 22篇 |
1990年 | 8篇 |
1989年 | 23篇 |
1988年 | 8篇 |
1987年 | 7篇 |
1986年 | 7篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1980年 | 8篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1975年 | 5篇 |
1973年 | 6篇 |
1972年 | 6篇 |
1969年 | 3篇 |
1966年 | 4篇 |
1965年 | 3篇 |
排序方式: 共有3121条查询结果,搜索用时 15 毫秒
1.
Tetsuji Terazawa Takeshi Kato Masahiro Goto Katsuya Ohta Shingo Noura Hironaga Satake Yoshinori Kagawa Hisato Kawakami Hiroko Hasegawa Kazuhiro Yanagihara Tatsushi Shingai Ken Nakata Masahito Kotaka Masayuki Hiraki Ken Konishi Shiro Nakae Daisuke Sakai Yukinori Kurokawa Toshio Shimokawa Taroh Satoh 《The oncologist》2021,26(1):17-e47
Lessons Learned
- Panitumumab monotherapy showed favorable efficacy and feasibility in the treatment of frail or elderly patients with RAS wild‐type unresectable colorectal cancer.
- It is especially effective for left‐sided tumors; therefore, panitumumab as first‐line treatment could be an additional therapeutic option for frail elderly patients, particularly in those who are unsuitable for upfront oxaliplatin‐based or irinotecan‐based combination regimens.
2.
3.
4.
5.
Daisuke Ishii Daisuke Matsuzawa Shingo Matsuda Haruna Tomizawa-Shinohara Chihiro Sutoh Eiji Shimizu 《The International journal of neuroscience》2019,129(1):1-9
Adolescence is a vulnerable period for developing anxiety-related mental disorders such as post-traumatic stress disorder (PTSD), which requires a long-term course of therapy when a traumatic event has been experienced during childhood. However, the biological mechanism underlying these age-dependent characteristics remains unclear. In the present study, we used early adolescent, late adolescent and adult (4-, 8-, and 15-week old) male mice to examine age differences in fear memory, fear extinction, and spontaneous recovery of fear. We also measured the activation of extracellular signal-regulated kinase (ERK) 2 in the dorsal hippocampus (dHip) and the basolateral amygdala (BLA) following a spontaneous recovery test. Our major findings were as follows: (1) early adolescent and adult mice did not recover the fear response; only late adolescent mice recovered the fear response. (2) The ERK2 in the dHip was more activated after the spontaneous recovery test in late adolescent mice than in adult mice, and the ERK2 in the BLA was more activated after the spontaneous recovery test in adult mice than in late adolescent mice. These results suggest that there exists a unique period in which spontaneous recovery occurs and that these late adolescent behavioral signatures may be related to alteration in the ERK2 phosphorylation in the dHip and BLA. 相似文献
6.
Takahashi Masaya Takahashi Katsuyuki Muguruma Kazuya Ohira Masaichi Nagayama Katsuya 《International journal of clinical oncology / Japan Society of Clinical Oncology》2022,27(2):348-353
International Journal of Clinical Oncology - It is known that the area under the plasma concentration curve of nedaplatin (AUCNDP) is associated with the relative reduction ratio of platelets and... 相似文献
7.
8.
Porphyromonas gingivalis has been implicated as a major pathogen in periodontitis. To determine the role of T cells in the regulation of this disease, a method was developed for the generation and characterization of rat T-cell clones with antigen specificity to P. gingivalis whole cells. The clones studied so far demonstrated a T-helper (Th) phenotype W3/13+, W3/25+, OX8− and OX22−. These T-cell clones proliferated in vitro in response to P. gingivalis, but not to other bacteria (Prevotella intermedia, Actinobacillus actinomycetemcomitans, Wolinella recta, Fusobacterium nucleatum, Streptococcus sanguis). Limiting dilution analysis showed W3/25+, OX8− T cells preferentially respond to P. gingivalis, rather than W3/25−, OX8+ T cells. P. gingivalis-reactive W3/25+ T cells belonged to the OX22− population, suggesting that the OX22− T cells may represent memory cells. All clones tested produced interferon γ, but not interleukin 2. The cloned T-cell F1 significantly enhanced P. gingivalis-specific antibody production (p < 0.03). The availability of these cloned T cells should bring new insight into the mechanism by which T cells regulate oral health and periodontal disease. 相似文献
9.
Keiichiro Sagawa Hiroyasu Furuya Yuki Ohara Mitsuyoshi Yoshida Hirohiko Hirano Katsuya Iijima Takeshi Kikutani 《Journal of prosthodontic research》2019,63(1):31-34
Purpose
The aim of this study was to determine the influences of oral motor function such as tongue function and bite force on masticatory performance in the elderly.Methods
We randomly selected 245 subjects who has 28 natural teeth among community-dwelling elderly. We evaluated masticatory performance using a gummy jelly, and also measured bite force, tongue muscle force, and the speed of tongue movement.Results
We found that reduced masticatory performance to be associated with decreased the speed of tongue movement and/or tongue muscle force, indicating that reduced oral motor function also influences masticatory performance.Conclusions
These results suggest that keeping oral motor function, as well as maintenance of occlusal support, to be important for maintaining masticatory function in the elderly. 相似文献10.
Fukunaga Tsugumi Anan Go Hirose Takuo Miyake Yuka Hoshino Kento Endo Akari Tajima Ryo Ito Hiroki Nakayama Shingo Hashimoto Hideaki Ishiyama Katsuya Kimura Tomoyoshi Mori Takefumi 《Clinical and experimental nephrology》2022,26(7):717-723
Clinical and Experimental Nephrology - The number of patients aged ≥ 75 years and who need renal replacement therapy is steadily increasing. The study aimed to determine... 相似文献