全文获取类型
收费全文 | 707篇 |
免费 | 31篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 14篇 |
妇产科学 | 8篇 |
基础医学 | 49篇 |
口腔科学 | 25篇 |
临床医学 | 29篇 |
内科学 | 290篇 |
皮肤病学 | 8篇 |
神经病学 | 35篇 |
特种医学 | 36篇 |
外科学 | 63篇 |
综合类 | 3篇 |
预防医学 | 26篇 |
眼科学 | 14篇 |
药学 | 41篇 |
中国医学 | 2篇 |
肿瘤学 | 92篇 |
出版年
2023年 | 4篇 |
2022年 | 2篇 |
2021年 | 23篇 |
2020年 | 8篇 |
2019年 | 14篇 |
2018年 | 11篇 |
2017年 | 13篇 |
2016年 | 22篇 |
2015年 | 16篇 |
2014年 | 24篇 |
2013年 | 26篇 |
2012年 | 51篇 |
2011年 | 37篇 |
2010年 | 30篇 |
2009年 | 25篇 |
2008年 | 41篇 |
2007年 | 46篇 |
2006年 | 32篇 |
2005年 | 37篇 |
2004年 | 28篇 |
2003年 | 21篇 |
2002年 | 33篇 |
2001年 | 18篇 |
2000年 | 19篇 |
1999年 | 13篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 12篇 |
1991年 | 15篇 |
1990年 | 13篇 |
1989年 | 12篇 |
1988年 | 11篇 |
1987年 | 13篇 |
1986年 | 11篇 |
1985年 | 7篇 |
1984年 | 10篇 |
1983年 | 2篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1969年 | 2篇 |
1968年 | 2篇 |
1928年 | 1篇 |
排序方式: 共有746条查询结果,搜索用时 31 毫秒
1.
2.
M Konishi M Sawaki K Mikasa S Takeuchi K Hamada H Ako M Kunimatsu N Narita 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(11):1420-1424
We conducted a clinical study on respiratory infections complicating bronchial asthma. Transtracheal aspiration (TTA) was performed 37 times in 22 patients. The most frequently isolated organism was H. influenzae. The patients in whom organisms were isolated on TTA had a high incidence of fever and evidence of inflammation. Antimicrobial therapy caused a decrease in indices of inflammation (white blood cell count and ESR), but was less effective against the asthmatic symptoms. Respiratory infection may play a complex role in the clinical picture of bronchial asthma. 相似文献
3.
Okamoto T Hashimoto M Samejima H Mori A Wakabayashi M Takeda A Nakamura H Naruse H Bouike Y Araki N 《Immunopharmacology and immunotoxicology》2004,26(4):645-652
Immediate hemolytic transfusion reactions (IHTR) occurred in the course of delayed hemolytic transfusion reactions (DHTR). An 84-year-old man had received a blood transfusion 20 years ago. Progressive anemia developed, because of continuous bleeding from a bladder tumor. He was transfused with concentrated red blood cells (CRC) which were Rh-E antigen negative, because he had anti-E antibodies (day 0). He received CRC on day 3, and underwent resection of bladder tumor on day 6. Although crossmatch-compatible CRCs were prepared for the operation, those were not required and were kept in a refrigerator in the ward. On day 9, when a CRC kept in the ward was transfused, he suddenly had a IHTR. In order to analyze a mechanism of IHTR, the anti-Jk(b) and anti-Di(b) antibodies, anti-HLA antibodies and the concentrations of inflammatory cytokines were measured in serum samples. The anti-Jk(b) and anti-Di(b) antibodies increased prior to IHTR experienced on day 9. The concentrations of IL-6 and IL-1beta increased from day 2, while the concentration of IL-8 increased from day 7. The anti-HLA class I antibody could be detected 2 days before IHTR. Thus, the anti-Jk(b) and anti-Di(b) antibodies induced the production of inflammatory cytokines and symptoms of DHTR and IHTR. The anti-HLA class I antibody could be produced in spite of using the filer for removing leukocytes, and may take part in the induction of IHTR. Further, blood products should be transfused soon after completing a crossmatch test in patients with anti-RBC alloantibodies. 相似文献
4.
K Nishikawa T Morii H Ako K Hamada S Saito N Narita 《The Journal of allergy and clinical immunology》1992,90(2):169-174
The antigen, CD69, has been demonstrated to be expressed on activated T cells and natural killer cells. There have been no studies concerning the expression of CD69 on eosinophils. In this article, we demonstrate that lung eosinophils obtained from the bronchoalveolar lavage fluid of patients with eosinophilic pneumonia expressed significant levels of CD69, whereas peripheral blood (PB) eosinophils did not express CD69. We also activated PB eosinophils in vitro using phorbol myristate acetate and cytokines to determine whether CD69 was expressed. PB eosinophils expressed CD69 after short-term culture with phorbol myristate acetate and eosinophil hemopoietic cytokines (interleukin-3, granulocyte-macrophage--colony-stimulating factor, and interleukin-5). These findings suggest that CD69 may be a useful marker for activated eosinophils at inflammatory sites. 相似文献
5.
T Arimoto G Irie H Tsujii S Ito J Mizoe T Kamada M Miyamoto H Sirato 《Radiation Medicine》1984,2(3):205-209
In this paper a so-called "supralethal dose phenomenon" is reported. Two groups of patients, all of whom were carrying proved squamous cell carcinoma of the same clinical stage in their maxillary sinuses, were compared after radiotherapy in our department. The radiotherapies applied to the two groups were very similar in terms of fraction number, treatment period, dose distribution and immobilization technique, but differed in dose, i.e., 5,500 cGy for one group of 9 patients and 5,750 cGy for the other group of 20 patients. The five-year survival rates of the two groups were 8/9 and 10/20, respectively, and the difference was statistically significant (p less than 0.05). All patients were observed for at least five years. Except for tumor stage, the status of the patients in the two groups, including primary site of the tumor in the sinus, patients' age and cause of death for the failed cases, are also discussed in detail. 相似文献
6.
Clinical value of capsule endoscopy for detecting small bowel lesions in patients with intestinal Behçet's disease 下载免费PDF全文
7.
8.
Takahashi H Takeishi Y Seidler T Arimoto T Akiyama H Hozumi Y Koyama Y Shishido T Tsunoda Y Niizeki T Nozaki N Abe J Hasenfuss G Goto K Kubota I 《Circulation》2005,111(12):1510-1516
9.
Mayu Yazaki Takeru Nabeta Takayuki Inomata Kenji Maemura Takumi Oki Teppei Fujita Yuki Ikeda Shunsuke Ishii Takashi Naruke Yusuke Inoue Junya Ako 《Clinical cardiology》2021,44(2):222
BackgroundClinical significance of left atrial (LA) function and geometry in patients with dilated cardiomyopathy (DCM) remains uncertain.HypothesisLA geometric parameters assessed by cardiac magnetic resonance (CMR) predict the prognosis in patients with DCM.MethodsThe present study included patients with DCM and sinus rhythm who underwent CMR between December 2007 and April 2018. LA volume was measured using CMR. LA sphericity index was computed as the ratio of the measured maximum LA volume by the volume of a sphere with maximum LA length diameter.ResultsWe included 255 patients in this study. During the mean follow‐up of 3.92 years, hospitalization for HF occurred in 37 patients. The LA sphericity index was significantly higher in patients with hospitalization for HF than in those without (0.78 ± 0.35 vs. 0.58 ± 0.18, p < .001). Multivariable Cox regression analysis identified a higher LA sphericity index as an independent predictor of hospitalization for HF. Patients were categorized based on the median of LA sphericity index. The Kaplan–Meier curve showed that patients with a high LA sphericity index (≥0.57) had a significantly higher risk of hospitalization for HF than those with a low LA sphericity index (<0.57).ConclusionLA sphericity index was an independent predictor of hospitalization for HF. Assessment of LA geometric parameters might be useful for risk stratification in patients with DCM. 相似文献
10.