全文获取类型
收费全文 | 4817篇 |
免费 | 436篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 81篇 |
妇产科学 | 72篇 |
基础医学 | 705篇 |
口腔科学 | 112篇 |
临床医学 | 502篇 |
内科学 | 947篇 |
皮肤病学 | 75篇 |
神经病学 | 526篇 |
特种医学 | 196篇 |
外科学 | 765篇 |
综合类 | 144篇 |
一般理论 | 1篇 |
预防医学 | 478篇 |
眼科学 | 86篇 |
药学 | 244篇 |
中国医学 | 2篇 |
肿瘤学 | 265篇 |
出版年
2023年 | 28篇 |
2021年 | 111篇 |
2020年 | 53篇 |
2019年 | 106篇 |
2018年 | 108篇 |
2017年 | 93篇 |
2016年 | 98篇 |
2015年 | 95篇 |
2014年 | 137篇 |
2013年 | 216篇 |
2012年 | 280篇 |
2011年 | 301篇 |
2010年 | 160篇 |
2009年 | 158篇 |
2008年 | 203篇 |
2007年 | 245篇 |
2006年 | 246篇 |
2005年 | 212篇 |
2004年 | 207篇 |
2003年 | 175篇 |
2002年 | 165篇 |
2001年 | 122篇 |
2000年 | 140篇 |
1999年 | 138篇 |
1998年 | 57篇 |
1997年 | 53篇 |
1996年 | 36篇 |
1995年 | 39篇 |
1994年 | 31篇 |
1993年 | 32篇 |
1992年 | 74篇 |
1991年 | 79篇 |
1990年 | 82篇 |
1989年 | 81篇 |
1988年 | 85篇 |
1987年 | 72篇 |
1986年 | 73篇 |
1985年 | 53篇 |
1984年 | 42篇 |
1983年 | 35篇 |
1982年 | 30篇 |
1981年 | 25篇 |
1980年 | 24篇 |
1979年 | 30篇 |
1978年 | 36篇 |
1977年 | 24篇 |
1974年 | 29篇 |
1973年 | 23篇 |
1972年 | 30篇 |
1969年 | 24篇 |
排序方式: 共有5263条查询结果,搜索用时 31 毫秒
1.
Chronic pain in the UK affects up to 43% of the population. The consequences include physical and psychological distress, loss of function, employment, family and social strain and increased utilization of healthcare services. Modern pain management services operate across primary, secondary and tertiary care and incorporate general practitioners, psychologists, physiotherapists, pharmacists, specialist nurses, pain physicians and surgeons. This allows for a coordinated approach to chronic pain, engaging the patient in a structured pathway from conservative measures, through to surgery if necessary. Surgical interventions have been utilized effectively throughout the 20th century for the treatment of a variety of conditions, some of which are now effectively managed with improved pharmacological approaches or novel neuromodulation techniques. Ablative procedures that aim to permanently interrupt the pain pathway still represent the final solution for some conditions, particularly those with cancer associated pain; however, the search for less invasive, less risky measures continues. This is stimulated by an increased understanding of the neurobiology of pain transmission and the physiological changes which occur in persistent pain. 相似文献
2.
3.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献4.
Ronan O’Rahilly 《Irish journal of medical science》1948,23(11):738-742
5.
6.
D. Chattar-Cora R. Perez-Nieves A. McKinlay M. Kunasz R. C. Lyons 《European journal of plastic surgery》2007,29(5):221-226
Free tissue transfer has been demonstrated to be an effective modality of treating a variety of wounds and conditions in the
civilian population. The use of these procedures has been underreported by American military surgeons. Military surgeons face
unique hurdles that make the effective performance of these procedures difficult. We report our experience with free flap
reconstruction at an American Army medical center. We performed 44 free flaps in 38 patients; although operative times and
hospital length of stay were comparatively long, our success rates were excellent with only one partial flap loss.
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or
reflecting the views of the Department of the Army or the Department of Defense. 相似文献
7.
8.
Management of dislocations of both ends of the clavicle 总被引:2,自引:0,他引:2
J O Sanders F A Lyons C A Rockwood 《The Journal of bone and joint surgery. American volume》1990,72(3):399-402
We treated six patients who had a dislocation of both ends of the clavicle (an anterior dislocation of the sternoclavicular joint and a posterior dislocation of the acromioclavicular joint). Two patients who had fewer demands on the shoulder--an elderly woman and a woman who had had an ipsilateral amputation of the hand--did well; they had only minor symptoms after non-operative management. The other four patients (all men) had continuing pain at the acromioclavicular joint; each had a reconstruction of the joint, which resulted in a painless, full range of motion and return to normal activity. No patient had continuing pain in the sternoclavicular joint. 相似文献
9.
Wendy E. Marshman MD FRACO Christopher J. Lyons FRCS 《Clinical & experimental ophthalmology》1998,26(2):161-163
Purpose: To highlight an unusual organism causing a unilateral endophthalmitis by transplacental spread.
Method: We report a case of Plesiomonas shigelloides endophthalmitis, presenting in a newborn, with co-existing septicaemia and meningitis. There was a significant maternal history of diarrhoea associated with the ingestion of oysters 2 weeks prior to delivery.
Result: The endophthalmitis was treated with parenteral antibiotics and topical mydriatics with complete resolution, although subsequent assessment of the affected eye suggests a poor visual outcome.
Conclusion: Endophthalmitis in the newborn is an unusual clinical finding and usually presents with other manifestations of bacteraemia. Plesiomonas shigelloides is fortunately an infrequent cause of neonatal infection, but is associated with a high degree of morbidity and mortality. We postulate that this neonate acquired P. shigelloides via the transplacental route, and suggest that this organism be included in the list of 'other' causes of transplacental infection that has been abbreviated to 'O' in the acronym TORCH. 相似文献
Method: We report a case of Plesiomonas shigelloides endophthalmitis, presenting in a newborn, with co-existing septicaemia and meningitis. There was a significant maternal history of diarrhoea associated with the ingestion of oysters 2 weeks prior to delivery.
Result: The endophthalmitis was treated with parenteral antibiotics and topical mydriatics with complete resolution, although subsequent assessment of the affected eye suggests a poor visual outcome.
Conclusion: Endophthalmitis in the newborn is an unusual clinical finding and usually presents with other manifestations of bacteraemia. Plesiomonas shigelloides is fortunately an infrequent cause of neonatal infection, but is associated with a high degree of morbidity and mortality. We postulate that this neonate acquired P. shigelloides via the transplacental route, and suggest that this organism be included in the list of 'other' causes of transplacental infection that has been abbreviated to 'O' in the acronym TORCH. 相似文献
10.