全文获取类型
收费全文 | 175篇 |
免费 | 5篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 1篇 |
妇产科学 | 3篇 |
基础医学 | 18篇 |
口腔科学 | 25篇 |
临床医学 | 10篇 |
内科学 | 40篇 |
皮肤病学 | 1篇 |
神经病学 | 18篇 |
特种医学 | 3篇 |
外科学 | 28篇 |
综合类 | 1篇 |
预防医学 | 4篇 |
药学 | 9篇 |
中国医学 | 10篇 |
肿瘤学 | 5篇 |
出版年
2021年 | 4篇 |
2019年 | 3篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2014年 | 1篇 |
2013年 | 2篇 |
2012年 | 6篇 |
2011年 | 1篇 |
2010年 | 2篇 |
2009年 | 3篇 |
2008年 | 5篇 |
2007年 | 9篇 |
2006年 | 6篇 |
2005年 | 3篇 |
2004年 | 10篇 |
2003年 | 6篇 |
2002年 | 10篇 |
2001年 | 3篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 8篇 |
1991年 | 11篇 |
1990年 | 3篇 |
1989年 | 5篇 |
1988年 | 2篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 1篇 |
1976年 | 2篇 |
1975年 | 5篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 5篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1968年 | 4篇 |
1967年 | 1篇 |
1966年 | 2篇 |
1964年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有180条查询结果,搜索用时 31 毫秒
1.
Acupuncture analgesia (AA) caused by low frequency stimulation of the acupuncture point (AP) was abolished by hypophysectomy and adrenalectomy. Termination of the AA producing pathway from the AP to the pituitary gland was in the medial hypothalamic arcuate nucleus (M-HARN). The origin of the descending pain inhibitory system associated with AA was in the posterior HARN (P-HARN). AA in the hypophysectomized rats, and enhanced neuronal activity in the P-HARN that were abolished during acupuncture stimulation, were both restored by intraperitoneal microinjection of 0.5 mg/kg morphine or 0.1 micrograms beta-endorphin into the P-HARN during acupuncture stimulation. Of the analgesia produced by dopamine or beta-endorphin injected into the P-HARN, that caused by beta-endorphin disappeared after denervation of the M-HARN. The P-HARN neurons that responded to acupuncture stimulation also responded to iontophoretic dopamine, but not to iontophoretic morphine nor ultramicroinjected beta-endorphin. The transmission between the M-HARN and P-HARN may be dopaminergic, and beta-endorphin might presynaptically modulate this transmission. Reduction of sodium ions may have been the reason for abolition of AA after adrenalectomy. 相似文献
2.
Masato Sakamoto Koichiro Takeshige Hisataka Yasui Kouichi Tokunaga 《Surgery today》1998,28(5):522-528
(Received for publication on Sept. 12, 1996; accepted on May 12, 1997) 相似文献
3.
Expression of CD80 and CD86 on Peripheral Blood T Lymphocytes in Patients with Systemic Lupus Erythematosus 总被引:8,自引:0,他引:8
Abe K Takasaki Y Ushiyama C Asakawa J Fukazawa T Seki M Hirashima M Ogaki M Hashimoto H 《Journal of clinical immunology》1999,19(1):58-66
CD80 and CD86 were detected in high amounts on circulating T cells in the peripheral blood of some patients with systemic lupus erythematosus (SLE), using flow cytometry and monoclonal antibodies. Patients with other connective tissue diseases did not have a high percentage of T cells expressing CD80 or CD86 in their peripheral blood. CD80 was expressed mainly on CD4 T cells, whereas CD86 was expressed on CD8 T cells, and these two populations were associated with paticular clinical features. These two molecules were expressed on different T-cell populations and might have different roles in the generation and regulation of immune responses. Since high expression of CD86 on T cells was detected much earlier than the appearance of clinical features and a high titer of anti-DNA antibody, it may be a useful parameter for predicting the flare of SLE. 相似文献
4.
M Xu T Aiuchi K Nakaya H Arakawa M Maeda A Tsuji T Kato C Takeshige Y Nakamura 《Neuroscience letters》1990,118(2):205-207
Release of cholecystokinin-like immunoreactivity (CCK-LI) in the medial thalamus of conscious rats was measured by brain dialysis and enzyme immunoassay. Analgesia caused by low-frequency electric stimulation of the tibial muscle, the tsusanli acupuncture point, was judged by change of pain threshold due to the stimulation. Medical thalamic CCK-LI released was increased by peripheral electric stimulations of both the acupuncture point and the non-acupuncture point. Results suggest that CCK acts as a neurotransmitter in the medial thalamus, a part of the analgesia inhibitory system. 相似文献
5.
6.
Yukihiro Wada Hiroaki Ogata Yui Takeshige Akiko Takeshima Noriyo Yoshida Masahiro Yamamoto Hidetoshi Ito Eriko Kinugasa 《Clinical and experimental nephrology》2013,17(1):73-82
Background
Immunoglobulin (Ig) A nephropathy (IgAN) is characterized by mesangial deposits of IgA1 and C3, often with co-deposits of IgG. We attempted to clarify the clinical significance of mesangial IgG deposition in patients with IgAN.Methods
We retrospectively reviewed 57 patients who were diagnosed with IgAN on the basis of pathological examination of renal biopsy specimens obtained between October 2006 and December 2010. Subjects were divided into two groups: IgA+IgG deposition (IgA-IgG) group (n = 29) and IgA deposition alone (IgA) group (n = 28). The study outcome was complete remission (CR), defined as negative proteinuria by dipstick urinalysis and urinary erythrocytes of less than 1–4/high-power field.Results
Proteinuria was greater in the IgA-IgG group than the IgA group (1.1 ± 0.8 vs. 0.7 ± 0.6 g/day, Mann–Whitney U test, P = 0.042). Capillary wall IgA deposits were noted more frequently in the IgA-IgG group than the IgA group (59 vs. 11 %, Fisher’s exact test, P = 0.014). During the median follow-up period of 33.3 months (range 6–55 months) in the 57 patients, we observed CR in 24 cases (42.1 %). After the start of treatment, urinary abnormalities disappeared earlier in the IgA group than in the IgA-IgG group (log rank test, P = 0.012). Cox’s regression model showed that IgG deposition reduced the hazard ratio for CR (hazard ratio 0.35; 95 % confidence interval 0.14–0.82, P = 0.014). Therefore, IgG deposition is a risk factor for persistent urinary abnormalities.Conclusion
Mesangial IgG deposition is associated with more severe clinical features in patients with IgAN. 相似文献7.
8.
9.
Glucagon as the portal factor modifying hepatic regeneration 总被引:3,自引:0,他引:3
10.
The aim of this clinical study was to evaluate an allogeneic cultured dermal substitute (CDS) as a biological dressing for highly extended mesh auto-skin grafting. The subjects were five patients with extensive deep burn wounds. Allogeneic CDS was prepared by seeding fibroblasts on a spongy matrix of hyaluronic acid and atelo-collagen. Six-fold extended auto-skin graft was applied to the debrided wound, on which allogeneic CDS was placed. A conventional ointment-gauze dressing was used to protect the CDS. The CDS was applied repeatedly at intervals of 5-7 days. In all cases, the wounds were closed by successful take of mesh auto-skin graft and prompt epithelization from the grafted skin. The skin on the grafted area had a cicatrix appearance, but was soft and thin, maintaining good quality. The application of 6-fold extended auto-skin graft in conjunction with allogeneic CDS is an effective method for treatment of extensive severe burn wounds. 相似文献