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绝经后骨质疏松症的诱发因素很多,主要有种族及遗传因素、绝经后雌激素降低、营养因素、运动因素、不良生活习惯等,但其中最为主要的是绝经后雌激素降低这个因素。我的导师牟慧琴教授根据多年临床实践经验,研究出了一组经验方—延经丸,不但能调节患者体内的内分泌激素和性激素,镇静催眠的作用,而且对于防治女性绝经后骨质疏松症效果十分显著。本文重点从基础理论、组方分析、预防与治疗等方面进行探讨。 相似文献
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The objective of our study was to develop a mixed-micellar proliposomal formulation of poorly water-soluble drug progesterone and evaluate the dissolution profile and membrane transport. Several formulations of proliposomes were prepared by mixing different concentrations of lipid, progesterone, polysorbate 80, and microcrystalline cellulose. The mixed-micellar formulation of drug:dimyristoyl-phosphatidycholine:polysorbate 80 (1:20:3.3) exhibited the maximum dissolution (75.27%), while pure progesterone resulted in low dissolution. The above formulation showed a 4-fold increase in transport in Caco-2 cells and a 6-fold increase in transport across the everted rat intestinal sac experiments compared with control. Proliposomal formulations enhance the extent of dissolution and membrane transport of progesterone and serve as ideal carriers for oral delivery of drugs with low water solubility. 相似文献
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A.P. RELVAS
professor 《European journal of cancer care》2011,20(3):337-344
CHIQUELHO R., NEVES S., MENDES Á., RELVAS A.P. & SOUSA L. (2011) European Journal of Cancer Care 20 , 337–344 proFamilies: a psycho‐educational multi‐family group intervention for cancer patients and their families This paper describes a psycho‐educational multi‐family discussion group intervention for cancer patients and their families (proFamilies) which was implemented and evaluated at the IPOFG – CROC (Portuguese Cancer Institute, Regional Centre of Coimbra). It is a brief and highly structured programme which involves educational and support components and is based on multi‐family discussion groups, including patients and non‐patient family members. Five groups were established, involving 19 families, and a total of 57 people. The paper focuses on the practical aspects of the intervention, its development and its evaluation. Our results suggest that the programme responds to the patients' and their families' needs and that participation in proFamilies prevents an increase in the patient's level of psycho‐social maladjustment, promotes an adequate level of family cohesion and diminishes the perceived stress of patients and family members. 相似文献
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L. LETRILLIART md phd general practitioner L. MILLIAT-GUITTARD phd research fellow P. ROMESTAING md radio-oncologist A.M. SCHOTT md phd epidemiologist N. BERTHOUX nurse research assistant & C. COLIN md phd professor of epidemiology health economics 《European journal of cancer care》2009,18(2):131-139
Before electronic records become operational, patient-held records provide an opportunity to improve communication between patients and healthcare professionals. Our aim was to design the appropriate organization, layout and content for such a shared record for breast cancer management, based on a consensus between the various stakeholders. We therefore conducted a Delphi study within a working group of 48 members, including patients, oncologists, general practitioners, nurses and other professionals. The procedure featured three rounds during which participants' judgements were collected via mailed questionnaires and quantitative and qualitative feedback was provided on a regular basis. These three rounds were followed by an evaluation phase. Forty members (83%) participated in the three rounds. According to the agreement reached, the shared record was expected to include a front summary card, four sections for groups of users authorized to write down or insert information in the record (patient, physicians, medical auxiliaries and other healthcare professionals), and one section for medical imaging files. In addition, the record was to include specific categories of information as subsections within each of the various user sections. The participant satisfaction rate was over 90% for all aspects of the procedure, with the exception of interaction within the working group (79%). 相似文献
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Naser Tayyebi Meibodi Associate Professor Yalda Nahidi MD Mahmoud Mahmoudi Professor Zari Javidi Professor Maryam Rastin PhD Akram Sheikh BSc Habib Allah Esmaeeli Associate professor 《International journal of dermatology》2010,49(7):780-783
Background Human Herpesvirus type 8 (HHV‐8) is a new member of the herpes virus family, first found in the tissue of acquired immune deficiency syndrome (AIDS)‐related Kaposi’s sarcoma. Environmental factors including viral infection may play a role in the onset and/or development of pemphigus. Some studies based on polymerase chain reaction findings suggest an association between HHV‐8 and pemphigus. The aim of this study is investigation of the association of pemphigus with HHV‐8 and the relationship between inflammatory and acantholytic cells with HHV‐8 infection. Methods Tissue‐extracted DNA from 41 paraffin‐embedded skin tissues from patients first presenting with pemphigus was tested using nested PCR for the presence of HHV‐8. A total of 37 cases had pemphigus vulgaris (PV) and 4 patients had pemphigus foliaceus (PF). For our control group, normal skin of 21 cosmetic surgery patients were included. Furthermore, microscopic slides with H&E staining were evaluated for the number of inflammatory and acantholytic cells per microscopic field. Results Skin lesions from 13 of 37 patients (35.1%) with PV and 2 of 4 cases (50%) with PF were positive for HHV‐8 DNA. All specimens in our control group were negative for this virus. Conclusion HHV‐8 infection might be a contributing factor in the initiation or development of pemphigus. 相似文献