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排序方式: 共有238条查询结果,搜索用时 250 毫秒
1.
Jinhui Ma Kerry Siminoski Peiyao Wang Jacob L Jaremko Khaldoun Koujok Mary Ann Matzinger Nazih Shenouda Brian Lentle Nathalie Alos Elizabeth A Cummings Josephine Ho Kristin Houghton Paivi M Miettunen Rosie Scuccimarri Frank Rauch Leanne M Ward the Canadian STOPP Consortium 《Journal of bone and mineral research》2021,36(7):1255-1268
Vertebral fractures are clinically important sequelae of a wide array of pediatric diseases. In this study, we examined the accuracy of case-finding strategies for detecting incident vertebral fractures (IVF) over 2 years in glucocorticoid-treated children (n = 343) with leukemia, rheumatic disorders, or nephrotic syndrome. Two clinical situations were addressed: the prevalent vertebral fracture (PVF) scenario (when baseline PVF status was known), which assessed the utility of PVF and low lumbar spine bone mineral density (LS BMD; Z-score <−1.4), and the non-PVF scenario (when PVF status was unknown), which evaluated low LS BMD and back pain. LS BMD was measured by dual-energy X-ray absorptiometry, vertebral fractures were quantified on spine radiographs using the modified Genant semiquantitative method, and back pain was assessed by patient report. Forty-four patients (12.8%) had IVF. In the PVF scenario, both low LS BMD and PVF were significant predictors of IVF. Using PVF to determine which patients should have radiographs, 11% would undergo radiography (95% confidence interval [CI] 8–15) with 46% of IVF (95% CI 30–61) detected. Sensitivity would be higher with a strategy of PVF or low LS BMD at baseline (73%; 95% CI 57–85) but would require radiographs in 37% of children (95% CI 32–42). In the non-PVF scenario, the strategy of low LS BMD and back pain produced the highest specificity of any non-PVF model at 87% (95% CI 83–91), the greatest overall accuracy at 82% (95% CI 78–86), and the lowest radiography rate at 17% (95% CI 14–22). Low LS BMD or back pain in the non-PVF scenario produced the highest sensitivity at 82% (95% CI 67–92), but required radiographs in 65% (95% CI 60–70). These results provide guidance for targeting spine radiography in children at risk for IVF. © 2021 American Society for Bone and Mineral Research (ASBMR). 相似文献
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Divyang Patel Kevin M. Trulock Laurie Ann Moennich Erich L. Kiehl Anirudh Kumar Saleem Toro Eoin Donnellan Adam Grimaldi Bryan Baranowski Ayman A. Hussein Khaldoun G. Tarakji Daniel J. Cantillon Mark Niebauer Oussama M. Wazni Niraj Varma Bruce L. Wilkoff John W. Rickard 《Journal of cardiovascular electrophysiology》2020,31(5):1182-1186
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Ravi Shridhar MD PhD Jessica Freilich MD Sarah E. Hoffe MD Khaldoun Almhanna MD William J. Fulp MS MPH Binglin Yue Richard C. Karl MD FACS Kenneth Meredith MD FACS 《Annals of surgical oncology》2014,21(12):3744-3750
Purpose
We sought to determine the impact of esophagectomy on survival in patients with adenocarcinoma of the esophagus cancer after chemoradiotherapy (CRT).Methods
A database of esophageal cancer was queried for nonmetastatic patients with adenocarcinoma treated between 2000 and 2011 with CRT. Overall survival (OS) and recurrence-free survival (RFS) curves were calculated according to the Kaplan–Meier method and log-rank analysis. Multivariate analysis was performed by the Cox proportional hazard model.Results
We identified 154 patients (60 without surgery; 94 with surgery) who were included in the analysis. The only differences between the 2 groups were more advanced disease stage, improved performance status, and younger age in the surgery group. Patients undergoing surgery had significantly higher survival. Median and 5-year OS for surgical patients were 4.1 years and 43.6 %, versus 1.9 years and 35.6 % for nonsurgical patients (p = 0.007). Multivariate analysis for OS and RFS revealed that factors associated with increased survival were surgical resection, tumor length < 5 cm, male gender, and lower stage. Age, tumor location, radiation dose/technique, and induction chemotherapy were not prognostic. There was a trend toward improved survival on univariate analysis (p = 0.10) and multivariate analysis (p = 0.063) for surgical patients compared to nonsurgical patients who were healthy enough for surgery before CRT (n = 38), and no difference in OS in nonsurgical patients healthy enough for surgery after CRT (n = 22).Conclusion
Esophagectomy after CRT is associated with improved survival in patients with adenocarcinoma after CRT. Trimodal therapy should continue to remain the standard of care for esophageal adenocarcinoma. 相似文献7.
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Yousef Jaradat Morten Birkeland Nielsen Petter Kristensen Khaldoun Nijem Espen Bjertness Rita Bast-Pettersen 《Lancet》2018
Background
Nurses who are exposed to workplace aggression from patients, patient relatives, or colleagues are at risk for mental health disorders and job dissatisfaction. The aim of this study was to assess the prevalence of exposure to workplace aggression and the association between mental distress and job satisfaction in nurses working in the Hebron district of the occupied Palestinian territory.Methods
In this cross-sectional study, nurses were recruited to answer a questionnaire covering sociodemography and workplace aggression (WHO questionnaire), including exposure to physical and verbal aggression and bullying. We assessed mental distress with the General Health Questionnaire (GHQ-30) and job satisfaction with the Generic Job Satisfaction scale. Associations between workplace aggression and mental distress and satisfaction were estimated from χ2 tests and linear regression analyses using Stata/IC10. The study was approved by the ministry of health. Written informed consent was provided by all participants.Findings
In 2012, we recruited 372 registered nurses from the Hebron governorate. 28 (8%) nurses were excluded, and the final sample (n=344) included 213 (62%) women and 131 (38%) men. The prevalence of aggression of any kind was 27%. 17 (5%) nurses had been exposed to physical aggression, 83 (24%) had been exposed to verbal aggression, and 25 (7%) had been exposed to bullying. Men reported a higher prevalence of bullying than women (12% of men vs 5% of women). The prevalence of exposure to physical aggression, verbal aggression, and bullying was highest in young nurses. After adjusting for covariates, nurses exposed to verbal aggression reported 2·9 units (95% CI 0·02 to 5·6; p=0·04) more mental distress than non-exposed nurses. Bullying was associated with a 2·6 unit (95% CI ?5·1 to ?0·14) reduction in job satisfaction score.Interpretation
Nearly a third of nurses in this study reported exposure to some sort of aggression. Nurses exposed to verbal aggression reported more distress than nurses who had never been exposed to verbal aggression. Bullying was associated with reduced job satisfaction. Because the study had a cross-sectional design and both exposure and outcomes were measured using self-report, the results should be interpreted with caution.Funding
The Norwegian Programme for Development, Research and Education (NUFU pro x1 50/2002 and NUFUSM-2008/10232) and The National Norwegian State Education Loan Funds. 相似文献9.
Divyang Patel MD Peter Hu MD Henry Hilow MS Cameron T. Lambert MD Michelle Moufawad Stacy Poe Ayman A. Hussein MD Bryan Baranowski MD Mandeep Bhargava MBBS John W. Rickard MD MPH Daniel J. Cantillon MD Walid Saliba MD Bruce L. Wilkoff MD Oussama Wazni MD Khaldoun G. Tarakji MD MPH 《Pacing and clinical electrophysiology : PACE》2020,43(1):118-122
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