睾丸间质细胞瘤1例并文献复习

睾丸间质细胞瘤(Leydig cell tumor,LCT)又称kydig细胞瘤,是睾丸性索/性间质肿瘤的一种单一组织类型的肿瘤,是由正常发育和演化的成分间质细胞构成的.本病少见,约占睾丸肿瘤的1%～3%,占间质肿瘤的14%[1].2007年11月我院收治了1例睾丸LCT,现对其临床病理特征做初步探讨,以期提高对LCT的认识及诊治水平.     

外阴巨大尖锐湿疣1例

患者女性,20岁。因外阴部菜花状肿物进行性增大伴出血、恶臭2年入院。患者自述2年前出现外阴搔痒、起皮疹。初为散在点状丘疹,逐渐增长扩大,表面呈分叶毛刺状、融合成一巨大菜花状肿物,并伴有出血、恶臭。曾在多家医院就诊,效果不佳。入院后检查:外阴部及其周围见一菜花状肿物,大小约30cm×25cm×10cm,触之疼痛、出血。阴道内壁及肛门齿状线上下均有散在的疣状物。入院诊断:外阴部肿物,性质待定。在连续硬膜外麻醉下行肿物切除术,切除组织送病理。病理检查:巨检:菜花状肿物一个,大小为28cm×23cm×10cm,暗红色,表面呈大小不等的结节状,切面…     

肾脏原发性鳞状细胞癌5例临床病理学分析

目的：探讨肾脏原发性鳞状细胞癌临床病理学特征、诊断、鉴别诊断、治疗及预后。方法回顾性分析5例肾脏原发性鳞状细胞癌的临床表现、组织学形态和免疫表型特征,并复习相关文献。结果5例均为男性,平均年龄54．3岁,其中2例伴有肾盂结石。镜下见癌细胞呈巢状、片状排列,部分癌巢周边细胞呈栅栏状排列,可见细胞间桥及角化珠,伴有坏死。免疫表型：癌细胞 CK5/6和 p63均(+)、EMA(灶状+),CK20、CK7和vimentin均(-)。结论肾脏原发性鳞状细胞癌较少见,可能来源于化生性癌或起源于肾原基的未分化干细胞。免疫组化染色可辅助确诊,其恶性程度比肾透明细胞癌高,预后差。     

人组织型激肽释放酶6在卵巢上皮性肿瘤中的表达及其与临床病理特征和预后的关系

Objective To approach the relationship between the expression of hK6 in ovarian neoplasm and clinicopathological variables and prognosis in ovarian cancer patients for finding a new tumor marker of the ovarian cancer. Methods The expression of hK6 was detected by immunohistochemistry in 19 cases of benign, 11 cases of borderline and 45 cases of malignant ovarian neoplasms and statistically analyzed whether its expression correlate with clinicopathological variables and prognosis in patients with ovarian cancer. Results The expression of hK6 in ovarian cancer tissues (60.0%) was significantly higher than that in the benign (15.8%) and borderline (27.3%) ovarian neoplasm tissues (P < 0.01). The expression of hK6 in higher-grade ovarian cancer tissues (68.4%) was higher than that in low-grade ones (14.3%, P<0.05). The expression of hK6 in late-stage (stage Ⅲ ,76.7%) was significantly higher than that in early-stage (stage Ⅰ or Ⅱ ,26.7%, P < 0.01). The expression of hK6 was significantly higher in patients with lymph node metastasis (77.8%) than that in patients without (33.3% ,P<0.01). The expression of hK6 in the cancer tissues in the patients died, or with reeeurence or metastasis within 3 years after surgery was higher (75.0%) than that in the patients with stable disease (42.9%, P < 0. 05). Conclusion The expression of hK6 in ovarian cancer was higher than that in benign and borderline ovarian neoplasms. The expression of hK6 is higher in the ovarian cancer of late stage, higher-grade, with lymph node metastasis and is associated with a poorer prognosis, hK6 may become a new markers in prediction of prognosis of the patients with ovarian tumors.     

喉颗粒细胞瘤1例并文献复习

颗粒细胞瘤(granular cell tumor,GCT)初期被学者们认为来源于骨骼肌,而目前多数学者认同它是一种少见的来源于神经鞘雪旺(Schwann)细胞的肿瘤。尽管这种肿瘤的组织发生并不完全清楚,但是仍然具有特征性。现将我们收治的1例喉GCT患者临床资料报告如下,并回顾复习GCT文献。1资料与方法1.1临床资料患者,男,29岁,2007年5月因进行性声音嘶哑入我院耳鼻咽喉头颈外科。寻及病史3个月前无明显诱因出现声嘶,但没有咽喉部疼痛及异物感及呼吸吞咽困难,在当地医院按“声带肿物”行两次活检,病理报告均为慢性炎性反应,经抗炎等治疗无效,遂转入我院。1.2检查方法入我院后查体,间接喉镜下见左声带全长慢性充血,边缘无明显新生物,喉室膨隆,喉内表面黏膜光滑。行喉部CT示左侧喉室延及声门下一约1.5 cm实性肿物,周围组织无破坏(图1)。在支撑喉镜下切开喉室隆起处黏膜,暴露肿物,切取约0.3 cm×0.3 cm×0.2 cm组织活检。活检见肿物位于黏膜下,呈淡黄色,无明显包膜,质地较韧,血供较丰富。图1喉部CT示左侧喉室延及声门下一约1.3 cm×0.8 cm×0.8 cm实性肿物,周围软骨无破坏2结果病理检查...     

大肠癌雄激素受体表达的临床病理研究

目的 探讨大肠癌组织、癌周粘膜组织及外周血白细胞雄激素受体(AB)的含量与大肠癌发生发展的关系。方法 应用放射配体结合分析法(RBA)测定38例行手术切除的大肠癌组织、癌周粘膜组织及外周血白细胞雄激素受体的含量;同时用放射免疫法(RIA)测定大肠癌患者及正常人血浆雄激素(睾酮T)的水平,结合临床病理资料进行统计分析。结果 癌组织与癌周粘膜组织相比,AR含量明显升高,结肠癌组织蛋白AR:56±10pmol/g~(-1);直肠癌组织AR蛋白:57±12pmol/g~(-1);结肠癌和直肠癌周粘膜组织AR蛋白分别为34±10pmol/g~(-1)和27±12pmol/g~(-1))(P<0.01);高分化的癌组织蛋白AR含量(63±8pmol/g~(-1))明显高于低分化者(38±4pmol/g~(-1)(P<0.01);大肠癌患者血浆睾酮水平轻度增加;但白细胞AR表达:男(1186±127)位点·细胞~(-1);女(894±109)位点·细胞~(-1)明显高于正常对照组男(785±112)位点·细胞~(-1);女(697±105)位点·细胞~(-1)(P<0.01)。结论 大肠癌的发生可能与癌组织AR含量升高有关,AR含量与肿瘤的分化程度存在相关性。     

脑猪囊尾蚴病临床及病理学特点

目的 探讨脑猪囊尾蚴病的临床及病理学特点.方法 回顾性分析13例脑猪囊尾蚴病患者的临床资料,并结合文献对其影像学、病理学进行分析.结果 本组13例患者中,11例以癫痫发作为主要症状;6例病理学检查均发现囊尾蚴虫体;9例病灶周围脑组织可见炎症反应;在病灶及其周围的脑组织中可见散在的石灰小体.头部CT检查表现为片状或点状低密度影,病灶区MRI表现为囊性异常信号.结论 脑猪囊尾蚴病首发症状以癫痫发作多见;影像学检查对脑猪囊尾蚴病诊断有帮助,但最后确诊需病理学检查;病理学检查除找到囊尾蚴虫体外,脑组织中发现散在的石灰小体是诊断陈旧性病变的重要依据.     

人组织型激肽释放酶6在卵巢上皮性肿瘤中的表达及其与临床病理特征和预后的关系

Objective To approach the relationship between the expression of hK6 in ovarian neoplasm and clinicopathological variables and prognosis in ovarian cancer patients for finding a new tumor marker of the ovarian cancer. Methods The expression of hK6 was detected by immunohistochemistry in 19 cases of benign, 11 cases of borderline and 45 cases of malignant ovarian neoplasms and statistically analyzed whether its expression correlate with clinicopathological variables and prognosis in patients with ovarian cancer. Results The expression of hK6 in ovarian cancer tissues (60.0%) was significantly higher than that in the benign (15.8%) and borderline (27.3%) ovarian neoplasm tissues (P < 0.01). The expression of hK6 in higher-grade ovarian cancer tissues (68.4%) was higher than that in low-grade ones (14.3%, P<0.05). The expression of hK6 in late-stage (stage Ⅲ ,76.7%) was significantly higher than that in early-stage (stage Ⅰ or Ⅱ ,26.7%, P < 0.01). The expression of hK6 was significantly higher in patients with lymph node metastasis (77.8%) than that in patients without (33.3% ,P<0.01). The expression of hK6 in the cancer tissues in the patients died, or with reeeurence or metastasis within 3 years after surgery was higher (75.0%) than that in the patients with stable disease (42.9%, P < 0. 05). Conclusion The expression of hK6 in ovarian cancer was higher than that in benign and borderline ovarian neoplasms. The expression of hK6 is higher in the ovarian cancer of late stage, higher-grade, with lymph node metastasis and is associated with a poorer prognosis, hK6 may become a new markers in prediction of prognosis of the patients with ovarian tumors.     

青年痤疮患者白细胞雄激素受体的测定及意义

目的通过测定痤疮患者外周血雄激素及白细胞雄激素受体含量,旨在探讨雄激素及其受体对痤疮发生的影响.方法应用放射配体结合分析法测定白细胞雄激素受体含量,同时用放射免疫法检则血清雄激素水平.结果男性痤疮患者,血浆睾酮仅轻度升高,但其外周血白细胞AR的水平与对照组相比有明显升高,(P＜0.05);女性痤疮患者,血浆睾酮水平及外周血白细胞AR水平与对照组相比均明显升高.P＜0.01.结论雄激素及其受体含量增高在女性痤疮的发病中起着更重要的作用;痤疮的严重程度与睾酮水平及白细胞AR水平密切相关.