全文获取类型
收费全文 | 2958篇 |
免费 | 176篇 |
国内免费 | 147篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 146篇 |
妇产科学 | 79篇 |
基础医学 | 378篇 |
口腔科学 | 49篇 |
临床医学 | 329篇 |
内科学 | 629篇 |
皮肤病学 | 63篇 |
神经病学 | 172篇 |
特种医学 | 346篇 |
外科学 | 317篇 |
综合类 | 26篇 |
预防医学 | 242篇 |
眼科学 | 43篇 |
药学 | 248篇 |
1篇 | |
中国医学 | 8篇 |
肿瘤学 | 180篇 |
出版年
2023年 | 7篇 |
2022年 | 10篇 |
2021年 | 49篇 |
2020年 | 29篇 |
2019年 | 64篇 |
2018年 | 63篇 |
2017年 | 36篇 |
2016年 | 40篇 |
2015年 | 55篇 |
2014年 | 80篇 |
2013年 | 102篇 |
2012年 | 107篇 |
2011年 | 138篇 |
2010年 | 97篇 |
2009年 | 102篇 |
2008年 | 159篇 |
2007年 | 233篇 |
2006年 | 116篇 |
2005年 | 119篇 |
2004年 | 90篇 |
2003年 | 81篇 |
2002年 | 70篇 |
2001年 | 87篇 |
2000年 | 81篇 |
1999年 | 86篇 |
1998年 | 98篇 |
1997年 | 94篇 |
1996年 | 89篇 |
1995年 | 91篇 |
1994年 | 57篇 |
1993年 | 69篇 |
1992年 | 48篇 |
1991年 | 51篇 |
1990年 | 49篇 |
1989年 | 84篇 |
1988年 | 62篇 |
1987年 | 48篇 |
1986年 | 49篇 |
1985年 | 42篇 |
1984年 | 32篇 |
1983年 | 22篇 |
1982年 | 31篇 |
1981年 | 19篇 |
1980年 | 17篇 |
1979年 | 10篇 |
1978年 | 7篇 |
1977年 | 23篇 |
1976年 | 36篇 |
1975年 | 19篇 |
1967年 | 6篇 |
排序方式: 共有3281条查询结果,搜索用时 15 毫秒
1.
Alejandra Gordillo Hernández Eduardo Dominguez-Adame Lanuza Auxiliadora Cano Matias Rosario Perez Huertas Katherine Maria Gallardo Rodriguez Purificacion Gallinato Perez Fernando Oliva Mompean 《World journal of gastrointestinal surgery》2015,7(8):170-173
Gangliocytic paragangliomas are rare tumors that almost exclusively occur within the second portion of the duodenum. Although these tumors generally have a benign clinical course, they have the potential to recur or metastasize to regional lymph nodes. The case report presented here describes a 57-year-old female patient with melena, progressive asthenia, anemia, and a mass in the second-third portion of the duodenum that was treated by local excision. The patient was diagnosed with a friable bleeding tumor. The histologic analysis showed that the tumor was a 4 cm gangliocytic paraganglioma without a malignant cell pattern. In the absence of local invasion or distant metastasis, endoscopic resection represents a feasible, curative therapy. Although endoscopic polypectomy is currently considered the treatment of choice, it is not recommended if the size of the tumor is > 3 cm and/or there is active or recent bleeding. Patients diagnosed with a gangliocytic paraganglioma should be closely followed-up for possible local recurrence. 相似文献
2.
Jorge Cano Julián Campo Luis A Moreno Antonio Bascones 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2006,101(1):11-28
OBJECTIVE: Alveolar distraction is a relatively novel procedure by which alveolar bone and underlying mucosa are regenerated. The low predictability of other vertical or horizontal bone regeneration methods has increased interest in this promising technique. This article was designed to review published clinical and experimental results on alveolar distraction, including basic research in other disciplines (maxillofacial and orthopedic distraction) related to or with influence on alveolar distraction. STUDY DESIGN: A review of the international literature was performed to summarize results of clinical and experimental studies on alveolar distraction and on distraction at other anatomical sites that contribute important findings on tissue biology, molecular mechanisms, and other factors that influence and participate in the alveolar distraction process. RESULTS: Research into alveolar distraction has addressed the latency phase, distraction phase, and consolidation phase, yielding highly variable results. Little experimental research has been carried out on this procedure, and most publications are clinical studies with a short follow-up period. Published studies have reported a high rate of complications, attributable to our current lack of understanding of the process. CONCLUSIONS: Definitive conclusions on alveolar distraction are hampered by the lack of clinical and experimental studies to date. Greater knowledge of the factors that influence the distraction process will lead to a more predictable and efficacious distraction technique and a better distractor design. 相似文献
3.
4.
Researchers have demonstrated that certain types of pain coping are correlated with less pain severity and disability and that there are differences between Caucasians and African-American pain patients in their use of specific coping strategies. However, the extent to which racial group differences exist in the associations between pain coping strategies and pain severity, interference, and disability is unclear. Furthermore, the role of education in these associations is uncertain. We recruited a diverse community sample of individuals with chronic pain and their spouses to examine this issue (N = 105). Participants completed the Coping Strategies Questionnaire, Multidimensional Pain Inventory, and Sickness Impact Profile. Results showed that African-American participants reported significantly more pain severity, interference, and disability and reported using diverting attention and prayer and hoping pain-coping strategies significantly more often than Caucasian participants; however, only the racial group difference in prayer and hoping remained when controlling for education. We also examined whether race and education interacted with coping strategies in relating to pain and disability. Significant three-way interactions were found for physical and psychosocial disability, suggesting that educational level should be included in analyses exploring racial group differences. The results suggest the need for pain treatments that take into account the educational and cultural context of pain. PERSPECTIVE: This article demonstrates that demographic variables such as race and education should be considered together when evaluating the effectiveness of coping with pain. The findings have the potential to enhance research and clinical practice with diverse groups. 相似文献
5.
Evaluation of a Bayesian method of amikacin dosing in intensive care unit patients with normal or impaired renal function 总被引:2,自引:0,他引:2
B Lacarelle C Granthil J C Manelli N Bruder G Francois J P Cano 《Therapeutic drug monitoring》1987,9(2):154-160
Our study was designed to determine the population pharmacokinetic parameters of amikacin in intensive care unit patients and to develop a Bayesian method allowing individual estimation of pharmacokinetic parameters. A two-stage method was used for estimating the population characteristics of the pharmacokinetic parameters. Calculations of optimum doses and dosing intervals were based on individual parameters. Our results indicate that the Bayesian method is capable of estimating the individual pharmacokinetic parameters with no significant bias and good precision. Individualization of amikacin dosage was assessed 70 times in 52 patients. To determine the predictive performance of the method, observed peak and trough levels were compared with predicted values by computing precision, bias, and correlation. The amikacin dosing method was unbiased and showed a high correlation coefficient (r = 0.962) between measured and predicted drug serum concentrations. No significant differences were found between the predicted and observed peak (17.3 +/- 3.5 and 17.3 +/- 3.8 micrograms/ml, respectively) and trough (2.86 +/- 0.93 and 3.08 +/- 1.41 micrograms/ml, respectively) amikacin serum concentrations. Among the 52 patients, wide variations were observed in the pharmacokinetic parameters (Vd = 0.21-0.50 L/kg; t 1/2 = 1.1-22 h) and the daily doses (2.8-42 mg/kg/day). 相似文献
6.
Y Santoni A Iliadis J P Cano R Luccioni Y Frances 《Journal of pharmacokinetics and biopharmaceutics》1986,14(1):1-17
Plasma concentrations of isosorbide dinitrate (ISDN) and its two active metabolites 2-isosorbide mononitrate (2-ISMN) and 5-isosorbide mononitrate (5-ISMN) have been measured during and for 6 hr after intravenous infusion at a rate of 2.5 mg/hr during 1.75 hr in six cardiac patients, by a capillary gas chromatographic method. Data were analyzed by simultaneous modeling of the observed kinetics of the three compounds. Two or three phases were detected on the postinfusion ISDN concentration-time curves. ISDN concentrations declined with a mean terminal half-life of 2.81 hr +/- 0.7 SD. The mean systemic clearance of ISDN (2.9 L/min +/- 0.7 SD) and its mean total volume of distribution (259 L +/- 48 SD) were relatively high. Plasma 5-ISMN concentrations were 5- to 6-fold greater than those of 2-ISMN during the whole observation period. Maximum levels of 2-ISMN (6.7 ng/ml +/- 0.9 SD) and of 5-ISMN (27 ng/ml +/- 6 SD) occurred within a few minutes after the end of infusion. The mean half-lives of 2-ISMN (1.59 hr +/- 0.19 SD) and of 5-ISMN (3.78 hr +/- 0.79 SD) estimated by the model were smaller than those calculated by a model-independent method (2.95 hr +/- 0.41 SD and 5.98 hr +/- 2.22, respectively), but were in good agreement with those reported in the literature following separate administration of both metabolites to man. This study shows how such modeling can distinguish between metabolite formation and elimination processes and allow the determination of metabolite half-lives after administration of the precursor drug. 相似文献
7.
8.
Adverse reaction to intravenous gadoteridol 总被引:1,自引:0,他引:1
9.
E. Munteis J. F. Cano J. A. Flores J. E. Martinez-Rodriguez M. Miret J. Roquer 《European journal of neurology》2007,14(9):1048-1052
The aim of the study was to determine the prevalence of thyroid autoimmune disorders in a cohort of untreated multiple sclerosis (MS) patients and compare it with a stratified sample of an adult population. We prospectively studied 93 untreated MS patients. The control group included 401 healthy subjects selected by stratified sampling in a non-iodine-deficient area. Antithyroid antibodies (ATA) (antibodies against peroxidase and thyroglobulin) were considered positive at titres ≥149 IU/ml. Antibodies were positive in 11 MS patients (11.8%; 95% CI 5.3–18.4%). This prevalence was five times higher ( P = 0.0001) when compared with that in the control population. We found six cases with subclinical hypothyroidism (6.45%; 95% CI 11.4–1.5) in contrast to 2.24% in the control group. Comparing MS with positive and negative ATA, there was a non-significant, slightly higher frequency of low Expanded Disability Status Scale (EDSS) score in the ATA-positive group (81% vs. 73.2%). One year after start of interferon (IFN) treatment, only one patient developed subclinical thyroid dysfunction. MS patients have a higher prevalence of ATA compared with the general population. An initial ATA and thyroid-stimulating hormone (TSH) determination is recommended in all MS patients. A periodic assessment of thyroid function during IFN treatment only seems to be justified in those cases where positive ATA or dysfunction is present before treatment. 相似文献
10.
M. L. Vizuete M. Santiago A. J. Herrera J. L. Venero A. Machado J. Cano 《Journal of neural transmission (Vienna, Austria : 1996)》1991,85(3):231-242
Summary Levels of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (serotonin, 5-HT) and their metabolites, and the activities of tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and monoamine oxidase A and B (MAO-A and MAO-B) have been determined in the rat posterior thalamus after enucleation during postnatal development. DA and 5-HT turnover rate have been measured as 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) accumulation rates after central decarboxylase inhibition by 3-hydroxybenzylhydrazine (NSD-1015). The major changes were an increase in noradrenergic and serotoninergic metabolism in enucleated animals compared with control animals. A decrease of the MAO-A to MAO-B ratio during postnatal development was found.Abbreviations
DA
dopamine
-
DOPAC
3,4-dihydroxyphenylacetic acid
-
HVA
homovanillic acid
-
DOPA
3,4-dihydroxyphenylalanine
-
NA
noradrenaline
-
MHPG
3-methoxy-4-hydroxyphenylgly-col
-
NMN
normetanephrine
-
TRP
tryptophan
-
5-HTP
5-hydroxytryptophan
-
5-HT
serotonin
-
5-HIAA
5-hydroxy-3-indolacetic acid
-
TH
tyrosine hydroxylase
-
TPH
tryptophan hydroxylase
-
MAO-A
monoamine oxidase-A
-
MAO-B
monoamine oxidase-B
Recipients of fellowships from I.I.E. del FISS Reincorporación de doctores y tecnólogos del M.E.C., and Perfeccionamiento de doctores y tecnólogos del MEC, Spain 相似文献