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尿液吡啶酚(PYD)测定及240例人正常值李忆梅,袁振铎,罗先正,陈佩琴,张丽雅骨质疏松症已成为骨折发生的最危险因素之一,日益引起更多的临床关注。有报道认为,在临床出现骨质疏松症状之前,很早就可以有过量骨吸收存在,故早期诊断过量骨吸收防治骨质疏松就成... 相似文献
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以自拟养神益智汤加减治疗老年性痴呆49例,6个月为1个疗程,1~2个疗程观察疗效,结果治愈率28.6%,,有效率89.8%。 相似文献
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<正> 急性心肌梗塞(以下简称 AMI)患者常死于共并发症。如能预知有无并发症发生,从而采取相应措施,则将进一步改善 AMI 的临床疗效。我们以前注意到了 cAMP 可作为判断 AMI 的预后的指标,现又同时平行观察了 cGMP 对判断 AMI 预后的意义。我们于1980年1月至1981年8月对96例 AMI 患者进行了血浆环磷酸乌苷(cGMP)和环磷酸腺苷(cAMP)含量的测定,以探讨这二个指标对判断 AMI 预后的价值。 相似文献
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目的探讨慢性乙型肝炎患者肝组织过渡型CK19阳性表达细胞与肝癌前病变变的关系.方法用LSAB免疫组化染色方法观察慢性乙型肝炎患者肝组织CK19的表达,并对患者每3个月检查B超和血清AFP,随访至1年.结果肝组织出现卵圆细胞分化为肝细胞的过渡型CK19阳性表达细胞的患者大多数出现血清AFP的明显升高,随访至1年,有1例患者出现小肝癌,1例出现肝实质低回声结节.结论过渡型CK19阳性表达细胞可作为一种新的可能的肝癌前病变的病理学标志. 相似文献
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用放射免疫测定法测定了9份华支睾吸虫和9份猪囊尾蚴匀浆中cAMP和cGMP的含量。cAMP的平均值各为82.1±7.26PM/10mg蛋白质和58.5±4.28pM/10mg蛋自质;cGMP的平均值各为20.1±2.4PM/10mg蛋白质和18.8±2.3pM/10mg蛋白质。结果提示这两种寄生虫虫体匀浆中cAMP和cGMP的测定,可能有助于对寄生虫代谢的调节机制的了解,并为寄生虫虫体内存在着cAMP第二信使提供了有力的证据。 相似文献
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过渡型CK19阳性表达细胞的研究 总被引:2,自引:0,他引:2
目的探讨慢性乙型肝炎患者肝组织过渡型CK19阳性表达细胞与肝癌前病变的关系。方法用LSAB免疫组织化学染色方法观察慢性乙型肝炎患者肝组织CK19的表达,每3个月对患者检查B超和血清甲胎蛋白,随访至1年。结果肝组织出现卵圆细胞分化为肝细胞的过渡型CK19阳性表达细胞的患者,大多数出现血清甲胎蛋白的明显升高。随访至1年,有1例患者出现小肝癌,1例出现肝实质低回声结节。结论过渡型CK19阳性表达细胞有可能作为一种新的肝癌前病变的病理学标志。 相似文献
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Usefulness of determining a protein induced by vitamin Kabsencein detection of hepatocellular carcinoma 总被引:2,自引:0,他引:2
Objective Protein induced by vitamin Kabsence or antagonistⅡ(PIVKAⅡ),also called des-gamma-carboxy prothro mbin(DCP),is a sensitive marker for the diagnosis of hepatocellular carcinoma(HCC)inJapan and the United States since the sensitive kits were available(1998).PIVKAⅡis not usedin clinicaldiagnosis in China so far.The aimofthis study was to assess the diagnostic value of PIVKAⅡin Chinesepatients with HCC.
Methods Seru mPIVKAⅡandα-fetoprotein(AFP)levels were determined in 60 patients with HCCand 30patients with cirrhosis not carrying HCC.
Results The mean serumconcentration of PIVKAⅡin HCCpatients(784.3±1364.1,x±s)was higherthan thatin cirrhosis patients(16.1±31.7);this difference was highly significant(P<0.0001).When thecutofflevelof 40 mAU/ml was used as the level of discriminating HCCfromcirrhosis,51.7%of patients(31/60)with HCChad PIVKAⅡvalues above this level(sensitivity).Only 4 patients with cirrhosis hadsuch high PIVKAⅡlevels.Thus,the specificity of this test was 86.7%(26/30).Total accuracy was62.2%[(31+26)/(60+30)].Seven of 19 small HCCs(36.84%)had PIVKAⅡvalues above the cutofflevel.Concentrations of AFPabove 20 ng/ml were observed in 34 of60 patients with HCC(56.7%)and in11 patients with cirrhosis(36.7%).Eleven of 26 patients with HCC(46.2%)withoutincreased AFPhadconcentrations of PIVKAⅡgreater than 40 mAU/ml.No significant correlation was found between serumlevels of AFPand PIVKAⅡthat were measured in 60 HCCpatients(rs=0.101,P=0.247).Combiningthe information fromPIVKAⅡand AFPshowed anincrease of approximately 21.6%over AFPand 26.7%over PIVKAⅡalone.For small HCCpatients,combining the information from PIVKAⅡand AFPshowedan increase of approximately 15.8%over AFPalone and 21.1%over PIVKAⅡalone.
Conclusion PIVKAⅡis a useful early diagnostic marker for HCCand may be more sensitive whencombined with AFPin Chinese patients. 相似文献