人类绒毛膜促性腺激素放射免疫(PEG法)测定

我们采用30％聚乙二醇(PEG,分子量为6,000)作为人类绒毛膜促性腺激素(HCG)放射免疫测定中,结合标记抗原和游离标记抗原的分离剂。同时对60份血清标本,应用本法和双抗体法进行比较,结果两种方法无显著差异,且有非常显著的相关。现报道如下。 材料和方法 一、试剂:HCG标准液:~125I-HCG标记液;HCG血清(以上3种试剂由上海生物制品研究所供);30％PEG溶液(分子量为6,000)。 二、方法:见表1。     

COMPARATIVE EFFECTIVENESS OF CHINESE H3(CH3)AND LIU WEI DI HUANG WAN(LWDHW)IN FEMALE CLIMACTERIC AND THEIR MECHANISM OF ACTION

Observations on the comparative effectivenessof Chinese H_3 and Liu Wei Di Huang Wan(LWDHW,六味地黄丸)for patients with menopause aftersurgery,natural menopause and female climactericsyndrome immediately before and after menopauseshow the identical remarkable rates of improvementand effectiveness of 5970 and 61% respectively.Thisdrug of six constituents which enhances Kidney'senergy is used in treating endocrine disorders in agedpatients.Persistent use for one year gives definiteresults.Changes of FSH,LH and E_2 levels beforeand after CH_3 are not statistically significant(P>0.05);while after LWDHW,FSH declines(P<0.05),E_2 increases(P<0.05)but there is no change in LH.Maturation values of exfoliative cytology of vaginalepithelium in the two groups do not show significantchanges.The mechanism of action of CH_3 is mediat-ed through the cellular increase of cAMP,whichenhances the action of estrogen traces present in thebody;LWDHW probably acts through the hypothala-mic-pituitaric-gonadal axis.     

中国H3与六味地黄丸治疗更年期综合征的疗效比较

对手术后绝经、自然绝经2年与绝经前后患更年期综合征妇女进行 CH₃与六味地黄丸的对比观察示:CH₃与六味地黄丸改善症状的显效与有效率相同,分别为39%与61%,服用一年疗效持续而稳定;CH₃组 FSH、LH、E₂水平服药前后无明显变化（P>0.05）,而六味地黄丸组 FSH 降低（P<0.05）,E₂升高（P<0.05）,LH 无变化;阴道脱落细胞成熟值二组均无明显变化。CH₃是通过 cAMP 增强体内微量雌激素产生效用,而六味地黄丸则可能通过下丘脑—垂体—性腺轴起作用。