Inhibitors of Sortases of Gram-Positive Bacteria and their Role in the Treatment of Infectious Diseases (Review)

Pharmaceutical Chemistry Journal - The functions of sortase bacterial enzymes and their surface-protein substrates are reviewed. Their role in the pathogenesis of infectious diseases such as...     

Molecular-Genetic Basis of Gastrointestinal Stromal Tumor Personalized Therapy by Receptor Tyrosine Kinase Inhibitors (A Review)

Pharmaceutical Chemistry Journal - Studies of the pharmacotherapy of gastro-intestinal stromal tumor as examples of personalized medicine are reviewed. Peculiarities of the use of imatinib,...     

Development of New Dosage forms of Niclosamide with Increased Solubility and Cytotoxic Activity

Pharmaceutical Chemistry Journal - The work was devoted to increasing the solubility of the anthelmintic agent niclosamide (NS). Methods for increasing the solubility of NS were described....     

Antioxidant and Anti-Inflammatory Activities of Dihydroquercetin,its Aminomethylated Derivative,and their Inclusion Complexes with Cyclodextrin

Pharmaceutical Chemistry Journal - The antioxidant properties of dihydroquercetin (DHQ, taxifolin), its aminomethylated derivative (KH-14), and their inclusion complexes in cyclodextrin were...     

Nanostructured Porous Silicon Containers as Drug Carriers

Pharmaceutical Chemistry Journal - The possibilities of using porous silicon nanostructured containers as drug carriers are considered. The main design principles of the nanocontainers and the...     

Synthesis and Cytotoxicity of the Dihydroartemisinin Ester of 1,1′-Ferrocenedicarboxylic Acid

Pharmaceutical Chemistry Journal - The synthesis of the dihydroartemisinin ester of 1,1′-ferrocenedicarboxylic acid (III) is described. Results of in vitro studies of its effect on the...     

Viability of Tumor Cells (K562, Hep-2, HeLa) and Rat Fibroblasts in the Presence of Pterostilbene and Extracts of Licorice Root and Andrographis Paniculata

Pharmaceutical Chemistry Journal - Results from in vitro studies of the effect of pterostilbene, licorice root extract, and Andrographis paniculata extract on the viability of rat fibroblast and...     

Cardiomonitoring of the Effect of Perftoran on ECG Parameters under Conditions of Experimental Hypoxic Damage of the Myocardium

Myocardial damage is a metabolic phenomenon attributed to the lack of oxygen supply. The effect of the blood substitute perftoran on the ECG parameters registered was studied using the model of acute experimental epinephrine-induced hypoxic myocardial damage in rats. The introduction of perftoran prevented the development of changes in the ST segment and violations in the heart rhythm under the model damage conditions. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 4, pp. 10 – 12, April, 2005.     

Compressive and Tensile Elastic Properties of Concrete: Empirical Factors in Span Reinforced Structures Design

Concretes with the same strength can have various deformability that influences span structures deflection. In addition, a significant factor is the non-linear deformation of concrete dependence on the load. The main deformability parameter of concrete is the instantaneous modulus of elasticity. This research aims to evaluate the relation of concrete compressive and tensile elastic properties testing. The beam samples at 80 × 140 × 1400 cm with one rod Ø8 composite or Ø10 steel reinforcement were experimentally tested. It was shown that instantaneous elastic deformations under compression are much lower than tensile. Prolonged elastic deformations under compression are close to tensile. It results in compressive elasticity modulus exceeding the tensile. The relation between these moduli is proposed. The relation provides operative elasticity modulus testing by the bending tensile method. The elasticity modulus’s evaluation for the reinforced span structures could be based only on the bending testing results. A 10% elasticity modulus increase, which seems not significant, increases at 30–40% the stress of the reinforced span structures under load and 30% increases the cracking point stress.