Comparative efficacy of ivabradine versus beta-blockers in patients with mitral stenosis in sinus rhythm: systematic review and meta-analysis

International Journal of Clinical Pharmacy - Background Patients with mitral valve stenosis have increased heart rate. HR reduction is known as an important treatment and therapy strategy for...     

Identifying and prioritizing industry-level competitiveness factors: evidence from pharmaceutical market

Background

Pharmaceutical industry is knowledge-intensive and highly globalized, in both developed and developing countries. On the other hand, if companies want to survive, they should be able to compete well in both domestic and international markets. The main purpose of this paper is therefore to develop and prioritize key factors affecting companies’ competitiveness in pharmaceutical industry. Based on an extensive literature review, a valid and reliable questionnaire was designed, which was later filled up by participants from the industry. To prioritize the key factors, we used the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS).

Results

The results revealed that human capital and macro-level policies were two key factors placed at the highest rank in respect of their effects on the competitiveness considering the industry-level in pharmaceutical area.

Conclusion

This study provides fundamental evidence for policymakers and managers in pharma context to enable them formulating better polices to be proactively competitive and responsive to the markets’ needs.     

A Comparative Study of Intravenous Immunoglobulin and Subcutaneous Immunoglobulin in Adult Patients with Primary Immunodeficiency Diseases: A Systematic Review and Meta-Analysis

Subcutaneous immunoglobulin (SCIG) is a new therapeutic procedure for patients with primary immunodeficiency (PI). This research is a systematic review of studies on the efficacy and safety of intravenous immunoglobulin (IVIG) and SCIG in adult patients with PI. This study includes a systematic review of cohorts and randomized clinical trials (24 articles) from 5 databases with no time limits. Random effects meta-analysis was performed for outcomes such as efficacy and safety. Standard mean difference (SMD) of serum immunoglobulin level was equal to 0.336 (P <0.01; 0.205-0.467) and the odds ratio (OR) of side effects was 0.497 (P=0.1; 0.180-1.371). The results indicate that SCIG leads to a higher level of immunoglobulin and a reduction in side effects but shows the same infection rate as IVIG. Our analysis shows that shifting from IVIG to SCIG therapy can have clinical benefits for PI patients.     

Thermochemical CO2 splitting performance of perovskite coated porous ceramics

In this paper, we investigate the redox performance of perovskite coated porous ceramics with various architectures. For this purpose, reticulated porous ceramics (RPCs) in three different pore sizes (5, 12, 75 ppi) were fabricated to represent a broad range of structures and pore sizes. The perovskite material is based on lanthanum manganite and was synthesized and doped with Ca and Al through the Pechini method. Using a deep coating method, the surface of RPC substrates was modified by a thin-film coating with a thickness of ∼15 μm. We evaluated the CO₂ conversion performance of the developed materials in a gold-image IR furnace. X-ray micro-computed tomography along with SEM/EDX were utilized in different steps of the work for a thorough study of the bulk and surface features. Results reveal that the intermediate pore size of 12 ppi delivers the maximum perovskite loading with a high degree of coating homogeneity and connectivity while CO₂ conversion tests showed the highest CO yield for 75 ppi. Our results show that the extreme conditions inside the furnace combined with the flow of gaseous phases cause the RPCs to shrink in length up to 23% resulting in the alteration of the pore phase and elimination of small pores reducing the total specific surface area. Further our results reveal an important mechanism resulting in the inhibition of CO₂ conversion where the perovskite coating layer migrates into the matrix of the RPC frame.

A representative volume of LCMA coated porous SiC showing a maximum of 23% shrinkage when subject to high-temperature CO₂ conversion redox reactions. This results in significant structural changes including a reduction in specific surface area.