全文获取类型
收费全文 | 1980篇 |
免费 | 70篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 101篇 |
儿科学 | 84篇 |
妇产科学 | 81篇 |
基础医学 | 253篇 |
口腔科学 | 16篇 |
临床医学 | 108篇 |
内科学 | 435篇 |
皮肤病学 | 25篇 |
神经病学 | 229篇 |
特种医学 | 15篇 |
外国民族医学 | 1篇 |
外科学 | 97篇 |
综合类 | 11篇 |
预防医学 | 162篇 |
眼科学 | 61篇 |
药学 | 236篇 |
肿瘤学 | 154篇 |
出版年
2023年 | 8篇 |
2021年 | 44篇 |
2020年 | 11篇 |
2019年 | 22篇 |
2018年 | 30篇 |
2017年 | 13篇 |
2016年 | 28篇 |
2015年 | 26篇 |
2014年 | 37篇 |
2013年 | 46篇 |
2012年 | 111篇 |
2011年 | 120篇 |
2010年 | 64篇 |
2009年 | 49篇 |
2008年 | 142篇 |
2007年 | 184篇 |
2006年 | 181篇 |
2005年 | 182篇 |
2004年 | 211篇 |
2003年 | 205篇 |
2002年 | 150篇 |
2001年 | 33篇 |
2000年 | 20篇 |
1999年 | 26篇 |
1998年 | 14篇 |
1997年 | 11篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 4篇 |
1993年 | 5篇 |
1991年 | 5篇 |
1990年 | 2篇 |
1989年 | 9篇 |
1988年 | 6篇 |
1987年 | 11篇 |
1986年 | 3篇 |
1985年 | 9篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1979年 | 4篇 |
1977年 | 3篇 |
1975年 | 4篇 |
1974年 | 2篇 |
1972年 | 3篇 |
1970年 | 2篇 |
1967年 | 2篇 |
1966年 | 2篇 |
1965年 | 2篇 |
1964年 | 1篇 |
排序方式: 共有2069条查询结果,搜索用时 140 毫秒
1.
Marek Szolkiewicz Elzbieta Sucajtys Wojciech Wolyniec Przemyslaw Rutkowski Ewa Stelmanska Justyna Korczynska Julian Swierczynski Boleslaw Rutkowski 《Journal of renal nutrition》2005,15(1):166-172
OBJECTIVE: Hyperlipidemia is a permanent finding in advanced renal failure. It is supposed to be responsible for the accelerated arteriosclerosis and cardiovascular complications observed in patients with that disease. The background is partially determined, however, our knowledge in this matter is not yet satisfactory. METHODS: This study is based on the experimental rat model of chronic renal failure (CRF). Considering white adipose tissue (WAT) lipogenesis upregulation in CRF, along with the determination of acetyl coenzyme A carboxylase (ACC) and fatty acid synthase (FAS) genes expression, we have measured WAT gene expression for sterol regulatory binding protein 1 (SREBP-1) at the level of protein mass and mRNA abundance. Furthermore, we have determined glucose uptake, glucose-to-CO 2 conversion rate, and glucose translocator (GLUT-4) gene expression in WAT. RESULTS: Upregulation of both FAS and ACC gene expression was found in WAT of CRF rats. It was accompanied by WAT SREBP-1 gene overexpression. Moreover, we have observed the increased glucose uptake, glucose to CO 2 conversion rate, and GLUT-4 gene expression in WAT of CRF rats in comparison with controls. CONCLUSION: SREBP-1 gene overexpression may contribute to enhanced lipogenesis upregulation in WAT of CRF rats. It is not excluded that the increased WAT glucose metabolism activity is also induced by this mechanism, although there is no evidence currently to that end. We hypothesize that the increased WAT lipogenesis capacity could be a part of mechanism(s) leading to CRF-induced hyperlipidemia. 相似文献
2.
Ewa Andrzejewska Maciej Andrzejewski Elzbieta Socha Dorota Zych-Tomkowiak 《Dental materials》2003,19(6):501-509
OBJECTIVES: Resin-modified glass ionomer cements (RMGI) are hybrid materials prepared by incorporation of polymerizable components (typically 2-hydroxyethyl methacrylate (HEMA) with possible addition of multifunctional methacrylates) into a conventional acid-base mixture (a polymeric acid with powdered calcium fluoro-aluminosilicate glasses). During setting, the photopolymerization process and the acid-base reaction affect each other. The aim of this work was to examine the effect of a 45% aqueous solution of poly(acrylic acid) (PAA) and the liquid component of a commercial glass ionomer cement on HEMA and triethyleneglycol dimethacrylate (TEGDMA) photopolymerization. METHODS: The polymerization was initiated by 2,2-dimethoxy-2-phenylacetophenone (DMPA) and camphorquinone (CQ)/coinitiator system. The reaction course was monitored under Ar and air by isothermal differential scanning calorimetry. RESULTS: The main effect of addition of polyacid solution (PAA and commercial) up to 10wt% to HEMA on the polymerization initiated with DMPA was earlier onset of autoacceleration. For the process initiated by the CQ-based system, the addition of 5wt% of PAA solution strongly accelerated the polymerization and increased the conversion, both in Ar atmosphere as well as in air. TEGDMA photopolymerization was not influenced or slightly retarded by the presence of 3wt% of PAA solution (the upper limit of solubility), depending on the initiating system used. SIGNIFICANCE: Under initiation conditions used in curing of commercial dental products (CQ-based two component initiating system), the presence of polyacid-aqueous solution in HEMA-based photocurable component increases markedly the polymerization rate and the conversion both in Ar atmosphere as well as in air. This result contributes to a characterization of the setting process of RMGIs. 相似文献
3.
Tadeusz Kozielec Grazyna Durska Beata Karakiewicz Elzbieta Kedzierska 《Magnesium research》2004,17(2):85-89
We examined 83 mothers from Szczecin (north-west part of Poland) and their 83 neonates. Concentrations of total and ionized magnesium in maternal and cord serum, as well as total magnesium in hair were determined. Higher levels of total magnesium were noted in neonates (cord serum, hair) than mothers. A positive correlation was ascertained between total magnesium in maternal and cord serum. Magnesium in maternal hair correlated negatively with ionized magnesium in cord serum. Male neonates demonstrated higher levels of magnesium in cord blood and hair than females. There was no effect of maternal age, education level, or number of past pregnancies on the concentration of magnesium in mothers or neonates. 相似文献
4.
5.
In 1984 and at the beginning of 1985 the authors carried out radioimmunoassays (SORIN-CIS kit) the plasma levels of ACTH in 116 multiple sclerosis patients (m-52, f-64) and in 10 cases this radioimmunoassay was done in the cerebrospinal fluid (m-5, f-5). The control group comprised 90 patients with ischialgia and neuroses. The normal value in the plasma was from 0 to 80.86 pg/ml, and in the fluid it was from 0 to 77.08 pg/ml. In multiple sclerosis patients the plasma ACTH level was from 0 to 286.9 pg/ml, in the cerebrospinal fluid from 0 to 89 pg/ml. The values of ACTH were significantly higher in multiple sclerosis patients, mainly in males. In the fluid the level of ACTH was significantly higher in the studied patients. No significant differences in ACTH levels were found between males and females with multiple sclerosis, and in the control group this level was higher in females. Raised ACTH level was found mainly in multiple sclerosis with lung duration of the disease (10 years) at the time of exacerbations. The authors continue studies on the axis hypothalamus-hypophysis-adrenals, on various hormones, prostaglandins, beta-endorphin, biochemical markers, cAMP, cCMP, arylosulphatase A and B MBC etc. 相似文献
6.
Anna Gasinska Jan Skolyszewski Tadeusz Popiela Piotr Richter Zbigniew Darasz Krystyna Nowak Joanna Niemiec Beata Biesaga Agnieszka Adamczyk Krzysztof Bucki Krzysztof Malecki Marian Reinfuss Teresa Kowalska 《Journal of gastrointestinal surgery》2007,11(4):520-528
Purpose Assessment of tumor proliferation rate using Bromodeoxyuridine labeling index (BrdUrdLI) as a possible predictor of rectal
cancer response to preoperative radiotherapy (RT).
Methods and material Ninety-two patients were qualified either to short RT (5 Gy/fraction/5 days) and surgery about 1 week after RT (schedule I),
or to short RT and 4–5 weeks interval before surgery (schedule II). Tumor samples were taken twice from each patient: before
RT and at the time of surgery. The samples were incubated with BrdUrd for 1 h at 37°C, and the BrdUrdLI was calculated as
a percentage of BrdUrd-labeled cells.
Results Thirty-eight patients were treated according to schedule I and 54 patients according to schedule II. Mean BrdUrdLI before
RT was 8.5% and its value did not differ between the patients in the two compared groups. After RT tumors showed statistically
significant growth inhibition (reduction of BrdUrdLI). As the pretreatment BrdUrd LI was not predictive for early clinical
and pathologic tumor response, prognostic role of the ratio of BrdUrdLI after to BrdUrdLI before RT was considered. The ratios
were calculated separately for fast (BrdUrd LI > 8.5%) and slowly (BrdUrd LI ≤ 8.5%) proliferating tumors and correlated with
overall treatment time (OTT, i.e., time from the first day of RT to surgery). One month after RT, accelerated proliferation
was observed only in slowly proliferating tumors.
Conclusions Pretreatment BrdUrdLI was not predictive for early clinical and pathologic tumor response. The ratio after/before RT BrdUrdLI
was correlated to inhibition of proliferation in responsive tumors.
The paper was presented at ECCO 13, October 30 to November 03, 2005 in Paris, France 相似文献
7.
8.
Czarniak E Samet A Bronk M Rybak B Kochowska-Bronk M Zajac-Lenczewska I Ksiazek J Skokowski J 《Pneumonologia i alergologia polska》2003,71(1-2):31-35
The clinical specimens received from patients hospitalized in Department of Thoracic Surgery between 1997 and 2001 were microbiologically examined. The main specimen for microbiological examination was pleural fluid (median 34%). The frequency of specimens from bronchial tree increased significantly (from 4% to 26%) with concurrent decrease of sputum (from 29% to 6%). Among isolated pathogens, Gram negative rods were the most frequent (median 48%) and Pseudomonas sp. was the main pathogen among them. Occurrence of staphylococci was median 22% and Staphylococcus aureus, with a little decrease in analyzed period, was still the main Gram positive pathogen. Simultaneously the occurrence of MRSA in the last three years dropped three times. The number of isolations of yeasts have risen from 5.8% to 10.3%. 相似文献
9.
J Bia?ek A Denys M Kowalska T Szyd?owska 《Archivum immunologiae et therapiae experimentalis》1985,33(6):735-739
The influence of ISO, the antiviral drug of immunomodulating activity, on the course of experimental influenza infections and mixed, viral-bacterial infections was studied. Spleen leukocytes migration inhibition test, performed in vitro in the presence of specific antigens stimulating influence of the drug administered to the infected animals was observed. 相似文献
10.