全文获取类型
收费全文 | 1204篇 |
免费 | 94篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 76篇 |
妇产科学 | 14篇 |
基础医学 | 150篇 |
口腔科学 | 66篇 |
临床医学 | 113篇 |
内科学 | 251篇 |
皮肤病学 | 24篇 |
神经病学 | 42篇 |
特种医学 | 190篇 |
外科学 | 89篇 |
综合类 | 86篇 |
一般理论 | 1篇 |
预防医学 | 65篇 |
眼科学 | 5篇 |
药学 | 60篇 |
中国医学 | 24篇 |
肿瘤学 | 41篇 |
出版年
2022年 | 8篇 |
2021年 | 4篇 |
2020年 | 12篇 |
2019年 | 7篇 |
2018年 | 27篇 |
2017年 | 23篇 |
2016年 | 30篇 |
2015年 | 20篇 |
2014年 | 38篇 |
2013年 | 69篇 |
2012年 | 74篇 |
2011年 | 66篇 |
2010年 | 56篇 |
2009年 | 52篇 |
2008年 | 65篇 |
2007年 | 73篇 |
2006年 | 37篇 |
2005年 | 24篇 |
2004年 | 24篇 |
2003年 | 20篇 |
2002年 | 14篇 |
2001年 | 26篇 |
2000年 | 21篇 |
1999年 | 16篇 |
1998年 | 60篇 |
1997年 | 49篇 |
1996年 | 39篇 |
1995年 | 26篇 |
1994年 | 27篇 |
1993年 | 27篇 |
1992年 | 10篇 |
1991年 | 14篇 |
1990年 | 10篇 |
1989年 | 23篇 |
1988年 | 32篇 |
1987年 | 21篇 |
1986年 | 21篇 |
1985年 | 25篇 |
1984年 | 10篇 |
1983年 | 12篇 |
1982年 | 10篇 |
1981年 | 8篇 |
1980年 | 12篇 |
1979年 | 3篇 |
1978年 | 7篇 |
1977年 | 8篇 |
1976年 | 11篇 |
1975年 | 8篇 |
1974年 | 8篇 |
1973年 | 3篇 |
排序方式: 共有1303条查询结果,搜索用时 281 毫秒
1.
Katharine R. Owen Mollie Donohoe Sian Ellard Andrew T. Hattersley 《Diabetic medicine》2003,20(10):823-827
Background Familial partial lipodystrophy (FPLD) is a monogenic form of diabetes characterised by a dominantly inherited disorder of adipose tissue associated with the loss of subcutaneous fat from the limbs and trunk, with excess fat deposited around the face and neck. The lipodystrophy causes severe insulin resistance, resulting in acanthosis nigricans, diabetes, dyslipidaemia, and increased risk of cardiovascular disease. Preliminary results from animals and man suggest that increasing subcutaneous fat by treatment with thiazolidinediones should improve insulin resistance and the associated features of this syndrome. Case report We report a 24-year-old patient with FPLD caused by a mutation in the LMNA gene (R482W) treated with 12 months of rosiglitazone. Subcutaneous fat increased following rosiglitazone treatment as demonstrated by a 29% generalised increase in skin-fold thickness. Leptin levels increased from 5.8 to 11.2 ng/ml. Compared with treatment on Metformin, there was an increase in insulin sensitivity (HOMA S% 17.2–31.6) but no change in glycaemic control. The lipid profile worsened during the follow-up period. Conclusion This initial case suggests that, for modification of cardiovascular risk factors, there are no clear advantages in treating patients with FPLD with rosiglitazone despite increases in subcutaneous adipose tissue. Larger series will be needed to identify moderate beneficial effects and treatment may be more effective in patients with generalised forms of lipodystrophy. 相似文献
2.
Intracranial circulation: pulse-sequence considerations in three- dimensional (volume) MR angiography 总被引:2,自引:0,他引:2
The technique and feasibility of magnetic resonance (MR) angiography of intracranial vessels were studied in 35 healthy volunteers. Variations in image orientation, repetition time (TR), and flip angle were evaluated to determine their effects on flow-related enhancement. Gradient modifications--including echo time (TE), motion compensation, bandwidth, and field of view--were also studied in an effort to reduce motion-induced phase shifts. Results indicated that a FISP (fast imaging with steady precession) sequence with a TR of 50 msec, TE of 15 msec, velocity compensation in the read and section-select directions, acceleration compensation in the read direction, anisotropic volume, and a 1.25-mm partition thickness produced three-dimensional angiographic MR images that were accurate and reproducible in the depiction of the major intracranial vessels. Difficulties with field of view, persistent signal void secondary to higher-order motion, and spatial resolution remain major problems requiring additional study. 相似文献
3.
Maxillary sinusitis in adults: an evaluation of placebo-controlled double-blind trials 总被引:1,自引:0,他引:1
BACKGROUND: In general practice, acute sinusitis is frequently diagnosed
and treated with antibiotics. OBJECTIVE: This study aimed to determine the
evidence for the effectiveness of antibiotic treatment in acute maxillary
sinusitis in adults by assessing the methodological quality of
placebo-controlled double-blind randomized trials. METHOD: An evaluation by
four raters through a 35-item scoring-scale for internal and external
validity of all placebo-controlled double-blind randomized trials on acute
sinusitis found between January 1966 and July 1996. RESULTS: Eighty-five
trials were excluded because they were not placebo-controlled,
double-blind, randomized, or were carried out in patients with chronic
sinusitis or in children. The three remaining trials were performed in
different populations (one in general practice) between 1973 and 1978. Only
one study claimed superiority of antibiotic treatment. Different inclusion
criteria and major outcome measures were used by the authors. The
reliability of major outcome events was reported poorly or not at all and
in two studies outcome measures were clinically inappropriate. The studies
scored 30-62% of the maximum attainable score for internal validity and
10-20% for external validity. CONCLUSION: The effectiveness of antibiotic
treatment in acute maxillary sinusitis in a general practice population is
not based sufficiently on evidence.
相似文献
4.
In a series of experiments in which Mongolian gerbils were trained to jump over a variable gap, it was demonstrated that computation of the distance to be jumped was dependent on both image size and retinal motion, the latter cue being generated by the production of vertical translation movements of the head (head bobs). When image size was not a reliable cue, the animals produced more head bobs, thereby increasing the availability of retinal motion cues. The performance of the gerbils on various probe trials strongly suggested that they computed absolute distance by combining information about the velocity (or amplitude) of their head bobs with information about the velocity (or displacement) of the moving image of the landing platform. 相似文献
5.
6.
H Angus-Leppan GA Lambert J Michalicek 《Cephalalgia : an international journal of headache》1997,17(6):625-630
Co-existence of facial and occipital pain may occur in occipital neuralgia, migraine and cluster headache; suggesting convergence of trigeminal and cervical afferents. Such convergence has been shown in humans and other animals, but the site and extent of this are uncertain. In anaesthetized adult cats, the superior sagittal sinus and occipital nerve were stimulated electrically, and extracellular recordings made in the dorsolateral area of the upper cervical cord using glass-coated tungsten electrodes. Of 49 units in 10 cats, 33 (67%) had input from the superior sagittal sinus and the occipital nerve. Thirteen (27%) had superior sagittal sinus input and 3 (6%) had occipital nerve input. Convergent receptive fields were identified mechanically in 7 units. These experiments in cats show convergent input from occipital nerve and superior sagittal sinus on dorsolateral area units in two-thirds of cases studied. This experimental site of trigeminocervical convergence may relate to referral of pain in occipital neuralgia and other headaches. 相似文献
7.
In patients with PG-dependent renal function, NSAID administration
constantly reduces GFR and RBF in a dose-dependent fashion. In this
situation, the risk of overt acute renal failure is high and should be
taken into proper account. In contrast, the incidence of NSAID-related
renal structural alterations appears to be very low, yet the absolute
number of patients may be significant considering the wide use of such
drugs. Concerning the antiproteinuric effect of NSAIDs, the unfavourable
ratio risk/benefit does not seem to support their indication in proteinuric
nephropathies. The development of PGHS-2 selective inhibitors is promising,
and may open new therapeutical strategies in the treatment of the
progression of renal disease.
相似文献
8.
9.
10.