全文获取类型
收费全文 | 1474篇 |
免费 | 71篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 47篇 |
妇产科学 | 28篇 |
基础医学 | 219篇 |
口腔科学 | 137篇 |
临床医学 | 84篇 |
内科学 | 271篇 |
皮肤病学 | 31篇 |
神经病学 | 89篇 |
特种医学 | 43篇 |
外科学 | 222篇 |
综合类 | 10篇 |
一般理论 | 2篇 |
预防医学 | 99篇 |
眼科学 | 11篇 |
药学 | 92篇 |
中国医学 | 3篇 |
肿瘤学 | 112篇 |
出版年
2021年 | 23篇 |
2020年 | 22篇 |
2019年 | 22篇 |
2018年 | 22篇 |
2017年 | 13篇 |
2016年 | 28篇 |
2015年 | 35篇 |
2014年 | 42篇 |
2013年 | 52篇 |
2012年 | 67篇 |
2011年 | 74篇 |
2010年 | 42篇 |
2009年 | 52篇 |
2008年 | 81篇 |
2007年 | 96篇 |
2006年 | 57篇 |
2005年 | 49篇 |
2004年 | 44篇 |
2003年 | 48篇 |
2002年 | 45篇 |
2001年 | 36篇 |
2000年 | 40篇 |
1999年 | 31篇 |
1998年 | 17篇 |
1997年 | 11篇 |
1996年 | 12篇 |
1995年 | 12篇 |
1992年 | 32篇 |
1991年 | 23篇 |
1990年 | 14篇 |
1989年 | 16篇 |
1988年 | 17篇 |
1987年 | 10篇 |
1986年 | 14篇 |
1985年 | 21篇 |
1984年 | 21篇 |
1983年 | 16篇 |
1982年 | 13篇 |
1980年 | 13篇 |
1979年 | 17篇 |
1978年 | 13篇 |
1977年 | 13篇 |
1976年 | 17篇 |
1975年 | 13篇 |
1974年 | 22篇 |
1973年 | 11篇 |
1972年 | 17篇 |
1971年 | 13篇 |
1970年 | 11篇 |
1967年 | 10篇 |
排序方式: 共有1549条查询结果,搜索用时 31 毫秒
1.
Agata Cieślik-Bielecka Paweł Reichert Rafał Skowroński Tomasz Bielecki 《Platelets》2019,30(6):728-736
The current literature suggests that the antibacterial effect of leukocyte- and platelet-rich plasma (L-PRP) is directly related to platelet and leukocyte concentrations. The aim of this study was twofold: first, to evaluate the antimicrobial effect of L-PRP against selected bacterial strains in vitro, and second, to correlate this effect with leukocyte and platelet content in the final concentration. Blood was collected from 20 healthy males, and L-PRP, acellular plasma (AP), and autologous thrombin were consecutively prepared. Flow cytometry analysis of the blood, L-PRP, and AP was performed. The L-PRP gel, liquid L-PRP, and thrombin samples were tested in vitro for their antibacterial properties against seven selected bacterial strains using the Kirby–Bauer disk-diffusion method. There was notable antimicrobial activity against selected bacterial strains. No statistically significant correlations between antimicrobial activities and the platelet concentration in L-PRP were observed. Statistically significant positive correlations between selected leukocyte subtypes and antimicrobial activity were noted. A negative correlation was found between elevated monocyte count and antimicrobial activity of L-PRP against one bacterial strain studied. L-PRP possesses antimicrobial activity and can be potentially useful in the fight against certain postoperative infections. The bactericidal effect of L-PRP is caused by leukocytes, and there exists a relationship among selected leukocyte subtypes and L-PRP antimicrobial activity. 相似文献
2.
Schemm Stefanie A. Schemm Andreas Schwenkhagen Anneliese Schaudig Katrin 《Der Gyn?kologe》2019,52(6):463-472
Die Gynäkologie - Frauen im Erwachsenenalter mit einem angeborenen Herzfehler (EMAH) werden in Zukunft aufgrund des medizinischen Fortschritts eine immer größere Patientinnengruppe... 相似文献
3.
4.
Pawe? Reichert Roman Rutowski Krzysztof Zimmer Jerzy Gosk Krzysztof Bogdan Roman Wiacek 《Chirurgia narzadów ruchu i ortopedia polska》2007,72(3):175-179
Purpose of work was estimation of the results of treatment of pseudoarthrosis of the long bone with the method of decortication, with use of autogenic bone depends on kind of pseudoarthrosis and kind of osteosynthesis. In the years 1995-2005 56 patients were treated because of pseudoarthrosis of long bone in our Clinic. Pseudoarthrosis is classified according to Weber-Cech classification. In the methodology of clinical estimation and subjective estimation of the patient Stewart and Hundley and Anderson classification were used. Union was achieved in 51 cases. Time of bone union achievement was 5 months. The results of treatment are depends on morfology of pseudoartrosis and are independs of kind of osteosynthesis. 相似文献
5.
Jerry Z. Finklestein Mark D. Krailo Carl Lenarsky Stephen Ladisch Geoffrey K. Blair C. Patrick Reynolds Anneliese L. Sitarz G. Denman Hammond 《Pediatric blood & cancer》1992,20(4):307-311
The Childrens Cancer Study Group evaluated daily oral 13-cis-retinoic acid to determine its therapeutic efficacy in 28 children with advanced neuroblastoma refractory to conventional therapy. Cheilitis and fissured lips were the most common side effects; however, fewer than 50% of the patients experienced any toxicity. Two of twenty-two evaluable children demonstrated positive response to therapy. In one case, a child received the drug for 11 months. Seventeen patients demonstrated progressive disease within 28 days of the start of treatment. Three other patients with stable disease, or removed from study at day 28, were considered nonresponsive. Our data demonstrate that, when given as a single daily oral dose of 100 mg/m2, 13-cis-retinoic acid does not have significant activity in children with advanced neuroblastoma. © 1992 Wiley-Liss, Inc. 相似文献
6.
M. Hullmann T. E. Reichert R. Dahse F. von Eggeling H. Pistner H. Kosmehl und O. Driemel 《Mund-, Kiefer- und Gesichtschirurgie》2007,11(1):1-9
Zusammenfassung Die orale Zytologie erf?hrt eine Renaissance, die durch die Einführung der Bürste als Entnahmetr?ger und durch die Anwendung
zus?tzlicher moderner Verfahren bedingt ist. Die Bürste kann tiefe Schichten der oralen Mukosa erfassen, in denen die squam?se
intraepitheliale Neoplasie (SIN) beginnt. Zus?tzliche Verfahren zur Bewertung der biologischen Potenz der gewonnenen oralen
Epithelzellen sind: die computerunterstützte Bildanalyse (OralCDx?), die DNA-Zytometrie, die Immunzytochemie, die Dünnschichtzytologie und molekularbiologische Analysen. Alle genannten Verfahren
sind geeignet, die Sensitivit?t (bis zu 100%) und Spezifit?t (bis zu 100%) der oralen Zytologie zu erh?hen. Dennoch gibt es
Berichte über orale Plattenepithelkarzinome, die mithilfe der Bürstenbiopsie nicht erkannt wurden. Die Wertigkeit der einzelnen
Verfahren kann aktuell aufgrund fehlender vergleichender Studien nicht abschlie?end beurteilt werden. Die Immunzytochemie
mit kommerziellen Antik?rpern gegen Laminin 5 ist allseits verfügbar und methodisch einfach.
Das nichtinvasive diagnostische Verfahren der methodisch unterstützten oralen Bürstenbiopsie kann einen Beitrag zur frühen
Erkennung ausgew?hlter Mundschleimhautl?sionen leisten. Ein positiver Befund oder eine Progression der L?sion bei negativem
Befund sind Indikationen zur überweisung des Patienten an Fachkliniken und zur dort durchgeführten Skalpellbiopsie mit histopathologischer
Untersuchung. Die histopathologische Begutachtung bleibt der Goldstandard in der definitiven Diagnostik maligner oraler L?sionen.
相似文献
7.
Transection of an optic nerve (ON) is followed by slow removal of myelin. We studied microglia for the expression of molecules that characterize activated myelin phagocytosing macrophages: MAC-1, FcγII/III receptor (FcR), MAC-2, and F4/80. In-vitro, microglia expressed all molecules and phagocytosed myelin. In-vivo, intact ON displayed high levels of MAC-1, little FcR and F4/80, and no MAC-2. The expression of these molecules was upregulated differentially in in-vivo degenerating ON: MAC-1 uniformly, FcR and F4/80 variably, and MAC-2 sporadically. The distribution of MAC-2 expression correlated best with a pattern of sporadic structural degeneration. Thus in-vivo, ON injury is followed by deficient microglia activation, which we suggest contributes significantly to the slow clearance of myelin. 相似文献
8.
9.
Michael Fromm Wolfgang E. Berdel Hans D. Schick Susanne Danhauser-Riedl Ulrich Fink Wolfgang Remy Anneliese Reichert Anke Ankele Heinz W. Präuer Jörg R. Siewert Johann Rastetter 《Investigational new drugs》1988,6(3):189-194
Summary Carbetimer, a new synthetic low molecular weight polyelectrolyte with a novel structure displayed antitumor activiy in a number of animal tumor model systems and in vitro investigations. Based on these findings it was brought to a phase I clinical trial in patients with advanced malignant disease after failure of conventional treatment or with no conventional treatment available. Forty-eight patients received 98 courses. The schedule was a one hour i.v. infusion every four weeks. The starting dose was 180 mg/m2 and dose escalation was performed according to a modified Fibonacci formula up to 16,690 mg/m2. At least three patients were treated at each dose level and each patient was eligible to receive repeat courses at the same dose, until progressive disease or dose-limiting toxicity intervened. No hematological toxicity was encountered. Some adverse effects such as reversible proteinuria, hypercalcaemia, pain at infusion site, nausea and vomiting and fatigue were seen partly in a dose-related manner but did not represent the maximum tolerated dose (MTD). The limiting toxicity at the highest dose level of 16,690 mg/m2 consisted of ocular symptoms (light flashes) accompanied by a modest decrease of blood pressure and nausea or vomiting during a one hour infusion. 16,690 mg/m2/1 hour was considered the MTD. There were four deaths on study, all considered diseaserelated. Fourteen patients had stable disease for more than two courses, which, however, could also be explained by the natural course of disease. No clear-cut antitumor responses were noted in our study center.The recommended dose for phase II trials derived from our results is 12,550 mg/m2/2 hours. However, with regard to experiences in other phase I studies, the subsequent phase II studies will be performed with a dose of 6,500 mg/m2. 相似文献
10.
Susanne Krmer Clio Mamalaki Ivan Horak Anneliese Schimpl Dimitris Kioussis Thomas Hünig 《European journal of immunology》1994,24(10):2317-2322
The requirement for interleukin-2 (IL-2) in repertoire selection and peripheral activation of CD8 T cells was tested in mice rendered IL-2 deficient by gene targeting and expressing a transgenic T cell receptor (TcR) (F5) specific for influenza nucleoprotein (NP) 366-374 + H-2Db. Positive selection of the transgenic F5 TcR into the CD8 compartment proceeded normally. Both in vivo and in vitro, the antigenic peptide induced depletion of immature thymocytes and proliferation of mature CD8 T cells regardless of the presence of an intact IL-2 gene. In contrast, cytotoxic T lymphocyte (CTL) activity was only generated by T cells from IL-2+ F5 transgenic mice. Exogenous IL-2 was able to fully restore the CTL response of IL-2?/? responder cells in vitro. Thus, both in vivo and in vitro, clonal expansion of CD8 T cells can proceed in the absence of IL-2, whereas in peptide-immunized F5 transgenic mice, induction of cytotoxic effector function is IL-2 dependent. 相似文献