An epidemiologic study of sleep-disordered breathing in a large sample of Chinese adolescents

Journal of Public Health - Sleep-disordered breathing (SDB) is common among adolescents and is associated with short- and long-term consequences. Data on the prevalence and epidemiologic...     

One novel susceptibility locus associate with systemic lupus erythematosus in Chinese Han population

The aim of the study is to explore additional susceptibility factors for systemic lupus erythematosus (SLE) in Chinese Hans. Based on our previous GWAS of SLE, we performed a multistage replication study involving 3,152 cases and 7,050 controls from China to identify additional susceptibility loci for SLE by using the Sequenom MassArray system. All Chinese Han samples used in this study were obtained from doctors through collaboration with multiple hospitals in two geographic regions (central and southern China). Single-marker association analyses were performed using logistic regression with gender as a covariate in each case–control cohort. The joint analysis of all combined samples was performed using logistic regression with gender and sample cohorts as covariates. The significant association evidence for rs906868 (OR = 1.14, 95 % CI 1.08–1.20, P _combined = 7.71 × 10^?10) and rs7579944 (OR = 1.13, 95 % CI 1.07–1.19, P _combined = 5.55 × 10^?9) was observed, which located at 2p23.1. In this region, limb bud and heart development homolog (LBH) was the only gene indicated, suggesting LBH might be a susceptibility gene for SLE, although its function was still unknown. The results indicated that the SNP rs7579944, rs906868 at 2p23.1 showed significant association with SLE. The genes LBH which located in this loci might be the predisposing genes of SLE.     

老年患者骨科植入物手术医院内获得性感染分析及防控对策

目的分析老年患者骨科植入物手术医院内获得性感染(HAI)的发生率及危险因素,探讨防控对策。方法回顾分析2013年7月1日至2015年6月30日期间在广州军区广州总医院行骨科植入物手术的老年患者1338例。统计分析HAI的发病情况及危险因素。结果发生HAI103例,感染率7.7%。最常见的HAI部位为下呼吸道,占总感染的36.97%,其次为泌尿系统和手术深部切口,分别占35.29%和10.08%。共检出细菌数116株,多重耐药菌占63.79%,其中排在前5位细菌分别是大肠埃希菌、鲍曼不动杆菌、肺炎克雷伯菌、铜绿假单胞菌和屎肠球菌。性别、年龄、手术类型、合并基础疾病、手术时间、术中输血量、术中输液量、住院时间和术前住院时间、侵入性操作和美国麻醉师协会(ASA)评分与骨科植入物手术HAI发生率密切相关(P0.05)。结论为降低骨科老年患者植入物手术HAI的发生率,应注重老年患者骨科围手术期的各个环节:术前应做好充分评估,有效控制基础疾病;术中应尽量缩短手术时间,减少术中出血及输液量;术后需加强对呼吸机、中心静脉导管、导尿管等侵入性操作的流程管理。