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Rakiya Saidu 《Current obstetrics and gynecology reports》2016,5(3):196-202
Vulvar cancer is rare, but its incidence is increasing particularly in young women. This increase has been attributed to increasing human papillomavirus (HPV) infection with high-risk types of HPV. There is an association between HPV and vulvar cancer, but the pathophysiology of this relationship is not fully understood, nor is the complexity of HPV/HIV co-infection and its association with vulvar cancer. Even with the limited literature, there is real evidence on the interrelationship between HPV, vulvar cancer in HIV-positive women, and that in the setting of HIV infection, careful examination of the vulva is necessary, and a biopsy must be taken from any suspicious lesion. Management of these patients should be multidisciplinary. 相似文献
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Xingjia Wu BS Stephanie Alberico BS Edward Saidu BS Sazzadur Rahman Khan PhD Shijun Zheng PhD Rebecca Romero BS Hyun Sik Chae PhD Sheng Li PhD Amane Mochizuki PhD Juanita Anders PhD 《Wound repair and regeneration》2015,23(1):104-114
A major complication for diabetic patients is chronic wounds due to impaired wound healing. It is well documented that visible red wavelengths can accelerate wound healing in diabetic animal models and patients. In vitro and in vivo diabetic models were used to investigate the effects of organic light emitting diode (OLED) irradiation on cellular function and cutaneous wound healing. Human dermal fibroblasts were cultured in hyperglycemic medium (glucose concentration 180 mM) and irradiated with an OLED (623 nm wavelength peak, range from 560 to 770 nm, power density 7 or 10 mW/cm2 at 0.2, 1, or 5 J/cm2). The OLED significantly increased total adenosine triphosphate concentration, metabolic activity, and cell proliferation compared with untreated controls in most parameters tested. For the in vivo experiment, OLED and laser (635 ± 5 nm wavelength) treatments (10 mW/cm2, 5 J/cm2 daily for a total of seven consecutive days) for cutaneous wound healing were compared using a genetic, diabetic rat model. Both treatments had significantly higher percentage of wound closure on day 6 postinjury and higher total histological scores on day 13 postinjury compared with control. No statistical difference was found between the two treatments. OLED irradiation significantly increased fibroblast growth factor‐2 expression at 36‐hour postinjury and enhanced macrophage activation during initial stages of wound healing. In conclusion, the OLED and laser had comparative effects on enhancing diabetic wound healing. 相似文献
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Saidu K Onah J Orisadipe A Olusola A Wambebe C Gamaniel K 《Journal of ethnopharmacology》2000,71(1-2):275-280
The in vivo antiplasmodial, analgesic and anti-inflammatory properties of Erythrina senegalensis, an ornamental plant commonly used in Northern Nigeria for the treatment of fevers, was evaluated. Aqueous extracts of the stem bark of the plant was used for the study. The in vivo antiplasmodial activity of the aqueous extract against Plasmodium berghei was assessed using the suppressive and curative test procedures. Analgesic activity was assessed using the acetic acid (0.75%v/v) induced abdominal constriction, while the anti-inflammatory activity was evaluated on egg-albumin induced paw oedema in rats as a model of acute inflammation. The stem bark extract of E. senegalensis exhibited only slight antiplasmodial activity while significant (P<0.05) analgesic and anti-inflammatory effects were observed. Preliminary phytochemical analysis of the extract indicates the presence of alkaloids and glycosides. 相似文献
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Background:
Abdominal myomectomy remains the mainstay of surgical management of uterine fibroids in our environment. However, its benefit in women aged 40 years and above remains debatable.Materials and Methods:
An 11-year prospective study was conducted involving 98 women, aged 40 years and above, who had abdominal myomectomy for the treatment of uterine fibroid at the University of Maiduguri Teaching Hospital, Maiduguri. They were followed up regularly for 1–6 years to detect conception, resolution of symptoms and obstetrics performance. Data were analyzed using SPSS version 13.Results:
The mean age of the patients was 42.6±2.9 years and 77 (78.6%) of them were nulliparous. Lower abdominal swelling was the commonest clinical presentation and the mean uterine size was 18.6±8.5 weeks. Infertility with uterine fibroids was the indication for myomectomy in majority of the cases [48 (48.9%)], while pregnancy complications accounted for 11.2% (11) of the cases Fertility restoration was 10.4% among the infertile patients. There was complete resolution of symptoms in 35.9% of those who required symptomatic relief, and term pregnancies were recorded in 72.7% of patients with pregnancy complications.Conclusion:
Myomectomy is the recommended treatment of uterine fibroids in women aged 40 years and above with infertility and who wish to become pregnant. If there is no need for further fertility preservation, hysterectomy should be offered. 相似文献5.
Matteo Pagnesi Oscar Alberto Gomez Vilamajó Alejandro Meiriño Carlos Alberto Dumont Alexandre Mebazaa Beth Davison Marianna Adamo Mattia Arrigo Marianela Barros Jan Biegus Jelena Celutkiene Kamilė Čerlinskaitė-Bajorė Ovidiu Chioncel Alain Cohen-Solal Albertino Damasceno Rafael Diaz Christopher Edwards Gerasimos Filippatos Etienne Gayat Antoine Kimmoun Carolyn S.P. Lam Maria Novosadova Peter S. Pang Piotr Ponikowski Hadiza Saidu Karen Sliwa Koji Takagi Jozine M. ter Maaten Daniela Tomasoni Adriaan A. Voors Gad Cotter Marco Metra 《European journal of heart failure》2024,26(3):638-651
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Jesse Y. Obed Babagana Bako Joshua D. Usman Joel Y. Moruppa Saidu Kadas 《Archives of gynecology and obstetrics》2011,283(2):311-315
Purpose
To determine the recurrence rate and risk factors for recurrence following myomectomy. 相似文献8.
Patients with type 2 diabetes (normotensives, n=59; hypertensives, n=56) and matched controls (n=60) had salt taste perception determined using graded NaCl solutions ( 0-400 mmol 1(-1)). Diabetic hypertensives, diabetic normotensives and controls differed significantly in taste threshold to NaCl recognition (F=4.4, P=0.01) and prevalence of NaCl taste insensitivity (P=0.003). Taste threshold to NaCl recognition correlated positively with duration of diabetes (r=0.402, P=0.04) and was associated with mean arterial pressure (P<0.001), the association being significant after adjustment for age (P<0.001), gender (P< 0.001), family history of hypertension ( P< 001), body mass index (P<0.01), antihypertensive medication ( P<0.01) and proteinuria ( P<0.04). 相似文献
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A retrospective study was done to determine the incidence of congenital malformation of the brain among African infants over a 5 year period. Transfontanelle ultrasound (US) was performed on 98 infants consisting of 45 males and 53 females. The mean age was 2.6 months (range 1-11 months). Congenital malformation was present in 25.5% of the 98 cases studied, most of which were associated with hydrocephalus. Cerebral aqueduct stenosis was the commonest congenital anomaly encountered and was found in 24% of case. This study shows that transfontanelle US is a useful tool for diagnosis of congenital brain malformations in infants. 相似文献