全文获取类型
收费全文 | 1390篇 |
免费 | 107篇 |
国内免费 | 108篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 62篇 |
妇产科学 | 43篇 |
基础医学 | 243篇 |
口腔科学 | 39篇 |
临床医学 | 177篇 |
内科学 | 236篇 |
皮肤病学 | 23篇 |
神经病学 | 164篇 |
特种医学 | 153篇 |
外科学 | 111篇 |
综合类 | 38篇 |
预防医学 | 63篇 |
眼科学 | 24篇 |
药学 | 104篇 |
中国医学 | 2篇 |
肿瘤学 | 120篇 |
出版年
2021年 | 15篇 |
2020年 | 10篇 |
2019年 | 18篇 |
2018年 | 21篇 |
2017年 | 18篇 |
2016年 | 29篇 |
2015年 | 38篇 |
2014年 | 34篇 |
2013年 | 48篇 |
2012年 | 51篇 |
2011年 | 47篇 |
2010年 | 42篇 |
2009年 | 45篇 |
2008年 | 46篇 |
2007年 | 100篇 |
2006年 | 39篇 |
2005年 | 58篇 |
2004年 | 34篇 |
2003年 | 40篇 |
2002年 | 42篇 |
2001年 | 30篇 |
2000年 | 36篇 |
1999年 | 28篇 |
1998年 | 56篇 |
1997年 | 46篇 |
1996年 | 52篇 |
1995年 | 29篇 |
1994年 | 27篇 |
1993年 | 21篇 |
1992年 | 23篇 |
1991年 | 17篇 |
1990年 | 19篇 |
1989年 | 22篇 |
1988年 | 15篇 |
1987年 | 14篇 |
1986年 | 19篇 |
1985年 | 9篇 |
1984年 | 8篇 |
1977年 | 7篇 |
1975年 | 13篇 |
1972年 | 7篇 |
1971年 | 8篇 |
1969年 | 8篇 |
1968年 | 7篇 |
1958年 | 7篇 |
1943年 | 10篇 |
1933年 | 6篇 |
1932年 | 6篇 |
1931年 | 9篇 |
1880年 | 6篇 |
排序方式: 共有1605条查询结果,搜索用时 46 毫秒
1.
The recently developed ELISA for the thrombin-antithrombin III complex (TAT) is a sensitive, specific, and simplified means of detecting intravascular coagulation. For further evaluation of the thrombogenicity of a polyamide (P) and a Hemophan (H) hollow-fibre dialyzer a cross-over study was done in ten stable patients on maintenance hemodialysis. At the same doses of heparin (mean bolus of 30 U/kg bw and maintenance doses of 86 U/kg bw), thrombin time and partial thromboplastin time were significantly lower using H. At the end of dialysis TAT was significantly higher in H (mean +/- SEM before HD 3.57 +/- .56, at 240 min 14.9 +/- 6.5 ng/ml, p less than 0.05, Wilcoxon-test) than in P (before HD 4.36 +/- .98, at 240 min 8.95 +/- 3.0 ng/ml, p less than 0.05 H 240 vs. P 240, Wilcoxon-test). Visible clotting was more pronounced in the H filter. Among other favourable features of blood compatibility the polyamide/polyvinylpyrrolidone copolymer with a hydrophilic/hydrophobic microdomain structure has less thrombogenicity. The modified cellulosic membrane H has advantages in complement activation and leukocyte depression, but thrombogenicity seems less favourable since the incorporated diethyl-amino-ethyl groups with their positive charge bind and inactivate negatively charged heparin. 相似文献
2.
C. Hueter Ledderhose R. Schultze 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1882,17(5-6):577-582
Ohne Zusammenfassung 相似文献
3.
Axel Olsen T. Antoine Frommolt Theo Pütz Rudolf Koch Hans Heidler Kurt Walther Schultze H. A. Schmitz Elisabeth Koch Möhlmann Diethelm W. Janisch-Raschkowitsch Hansen Ostertag H. Dietel 《International journal of legal medicine》1943,37(3-4):197-206
Ohne Zusammenfassung 相似文献
4.
Jeroen Kool Sebastiaan M van Liempd Huub van Rossum Danny A van Elswijk Hubertus Irth Jan N M Commandeur Nico P E Vermeulen 《Drug metabolism and disposition》2007,35(4):640-648
A high resolution screening (HRS) technology is described, in which gradient high-performance liquid chromatography (HPLC) is connected on-line to three parallel placed bioaffinity detection systems containing mammalian cytochromes P450 (P450s). The three so-called enzyme affinity detection (EAD) systems contained, respectively, liver microsomes from rats induced by beta-naphthoflavone (CYP1A activity), phenobarbital (CYP2B activity), and dexamethasone (CYP3A activity). Each P450-EAD system was optimized for enzyme, substrate, and organic modifier (isopropyl alcohol, methanol, and acetonitrile) in flow injection analysis mode. Characteristic P450 ligands were used to validate the P450-EAD systems. IC(50) values of the ligands were measured and found to be similar to those obtained with conventional microtiter plate reader assays. Detection limits (n = 3; signal-to-noise ratio = 3) of potent inhibitors ranged from 1 to 3 pmol for CYP1A activity, 4 to 17 pmol for CYP2B activity, and 4 to 15 pmol for CYP3A activity. The three optimized P450-EAD systems were subsequently coupled to gradient HPLC and used to screen compound mixtures for individual ligands. Finally, to increase analysis efficiency, a HRS system was constructed in which all three P450-EAD systems were coupled on-line and in parallel to gradient HPLC. The triple parallelized P450-EAD system was shown to enable rapid profiling of individual components in complex mixtures for inhibitory activity to three different P450s. 相似文献
5.
CM Reid M. Nelson P. Beckinsale P. Ryan LMH Wing LJ Beilin MA Brown GLR Jennings CI Johnston J. Marley JJ McNeil TO Morgan J. Shaw ID Steven MJ West 《Clinical and experimental pharmacology & physiology》1997,24(5):370-373
1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to identify subjects for a blood pressure (BP) screening programme. Blood pressure was measured on three occasions and eligible subjects were included if the average BP was 160 mmHg systolic or 90 mmHg diastolic if systolic BP was 140 mmHg. 3. Seven hundred and forty-one GPs were approached and 89 were enrolled in the study (12% of mail invites and 75% of those receiving a personal contact). In 16 practices where screening was completed, 82 000 records were reviewed to identify 4% patients eligible for screening. Twenty-two per cent of eligible subjects attended screening. Of 1938 subjects screened, 180 (9%) had BP 5=160/90 mmHg. Forty-seven percent of subjects (n = 916) were receiving antihypertensive therapy and 184 (20%) were withdrawn from therapy. One hundred and sixteen (63%) of these subjects had BP return to study entry levels within 6 weeks. Fifty-seven newly diagnosed and 81 previously treated subjects were randomized (7% of the screened population). 4. Based on the high participation rate of GPs, the response rate of patients to attend a BP screening programme and the 7% randomization to screening ratio for entry into the study, the ANBP2 pilot study has demonstrated that it is feasible to recruit subjects from Australian general practices to a cardiovascular outcome trial. 相似文献
6.
7.
Summary Ten mumps virus isolates recovered during an epidemic in Switzerland between Autumn 1992 and Spring 1993 were compared by nucleotide sequence analysis of the SH gene. The isolates were found to belong to two distinct yet closely related wild type strains in a newly identified European mumps virus lineage. 相似文献
8.
9.
Prof. Friedrich Schultze 《Journal of neurology》1920,65(1-2):1-25
Ohne ZusammenfassungHerr Dr. Sioli konnte auch bei erneuter Untersuchung mit Spirochätenfärbung und Bielschowsky-Färbung keinen andern Befund als früher erheben. Die Zahl der Achsenzylinder in den Herden ist nur in geringem Maße verringert. 相似文献
10.
Hannu Luomajoki Jan Kool Eling D de Bruin Olavi Airaksinen 《BMC musculoskeletal disorders》2007,8(1):90