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排序方式: 共有398条查询结果,搜索用时 187 毫秒
1.
Spindler A; Paz S; Berman A; Lucero E; Contino N; enalba A; Tirado S; Santana M; Zeballos A 《Nephrology, dialysis, transplantation》1997,12(1):128-132
Purpose. The objective of this study was to determine
the relationship between muscular strength and bone mineral density (BMD)
in patients undergoing regular haemodialysis. Methods.
The BMD was measured in the lumbar spine (L2L4) and in the proximal femur
(femoral neck and trochanter) with dual-energy X-ray absorptiometry (DEXA
(Lunar DPX). Muscular strength of the extensors, flexors and abductors
muscles of the femur (proximal muscles) and extensors muscles of the back
was measured with an isometric cynamometer. Thirty patients, 15 women with
a mean age of 33.7 years (18-43) and 15 men with a mean age of 15.5 years
(18-65) were included in the study. Results. There was
a positive and significant correlation between the BMD of the femoral neck
and muscular strength of the flexors (r=0.490, P<0.005), the
extensors (r=0.658, P<0.01) and the abductors muscles of the femur
(r=0.671, P <0.0008), as well as between the muscular strength of
the flexors (r=0.413, P <0.02) and extensors muscles of the femur
(r=0.433, P <0.01) with BMD of the trochanter. There was no
correlation between the muscular strength of the back extensor muscles and
the BMD of the lumbar spine (r=-0.119, P NS). There was no correlation
between the BMD and the number of years of haemodialysis therapy (r=-0.032,
P NS), the patient's age (r=-159, P NS), or the value of serum PTH
(r=0.369, P NS) respectively. However, there was a significant correlation
between the BMD of the femoral neck with muscular strength (r=0.602, P
<0.05). Conclusion. This study reveals the
close relationship that exists between muscular strength of the proximal
muscles and the BMD of proximal femur in patients undergoing haemodialysis. 相似文献
2.
Melody Okereke Nelson Ashinedu Ukor Yusuff Adebayo Adebisi Isaac Olushola Ogunkola Eseosa Favour Iyagbaye Greatman Adiela Owhor Don Eliseo Lucero‐Prisno 《The International journal of health planning and management》2021,36(1):13-17
The COVID‐19 pandemic continues to be a major public health threat globally and low‐ and middle‐income countries (LMICs) are not an exception. The impact of the COVID‐19 pandemic is far‐reaching on many areas including but not limited to global health security, economic and healthcare delivery with a potential impact on access to healthcare in LMICs. We evaluate the impact of the COVID‐19 pandemic on access to healthcare in LMICs, as well as plausible strategies that can be put in place to ensure that the delivery of healthcare is not halted. In order to mitigate the devastating effect of the COVID‐19 pandemic on the already weak health systems in LMICs, it is much necessary to reinforce and scale up interventions and proactive measures that will ensure that access to healthcare is not disrupted even in course of the pandemic. 相似文献
3.
Identical COL71A1 heterozygous mutations resulting in different dystrophic epidermolysis bullosa phenotypes 下载免费PDF全文
Nicole Knöpfel MD Lucero Noguera‐Morel MD Angela Hernández‐Martin MD Adela García‐Martin PhD Marta García PhD Ángeles Mencía PhD Rocío Maseda Pedrero MD Raúl de Lucas MD Maria José Escámez PhD Antonio Torrelo MD 《Pediatric dermatology》2018,35(2):e94-e98
Dystrophic epidermolysis bullosa is a rare blistering condition caused by mutations in the COL7A1 gene. Different clinical variants have been described, with dominant and recessive inheritance, but no consistent findings have been elucidated to establish a genotype–phenotype correlation. We present three unrelated patients with two identical pathogenic compound heterozygous mutations in the COL7A1 gene that developed different clinical forms of dystrophic epidermolysis bullosa—epidermolysis bullosa pruriginosa and mild recessive non‐Hallopeau–Siemens—raising the possibility of other genetic or environmental modifying factors responsible for the phenotype of the disease. 相似文献
4.
Marta Feito‐Rodríguez M.D. Lucero Noguera‐Morel M.D. José Casas‐Rivero M.D. Ph.D. Julio García‐Rodríguez M.D. Raul de Lucas‐Laguna M.D. 《Pediatric dermatology》2014,31(1):95-98
Group A beta‐hemolytic streptococcus cause most vulvovaginal infections seen in prepubertal girls. Bacterial vaginosis is a common cause of abnormal vaginal discharge in women of childbearing age but is rare in children. Data are insufficient to suggest that bacterial vaginosis is an exclusively sexually transmitted disease. We report a 10‐year‐old girl with no history or suspicion of sexual abuse who developed bacterial vaginosis in the context of a lichen sclerosus being treated with tacrolimus ointment. Secondary bacterial infection in lichen sclerosus is uncommon. We speculate that the immunosuppressive effect of topical tacrolimus could have triggered the infection. 相似文献
5.
Context: Bilastine is a new oral selective, non-sedating histamine H1 antagonist for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. The European Medicines Agency requires an Environmental Risk Assessment (ERA) for all novel medicines for human use. Objective: To calculate the bilastine predicted environmental concentration in surface water (PECsw; phase I ERA), and to determine the effects of bilastine on aquatic systems (phase II [tier A]). Materials and methods: Bilastine PECsw was calculated using the maximum daily dosage (20?mg), assuming that all administered bilastine was released into the aquatic environment. A persistence, bioaccumulation and toxicity assessment was conducted using the log Kow from the molecular structure. In phase II (tier A), a ready biodegradability test was performed, and bilastine’s potential toxicity to various aquatic and sediment-dwelling micro-organisms was evaluated. Results: Bilastine PECSW was calculated as 0.1?μg?L?1, and the compound was not readily biodegradable. Bilastine had no significant effects on Chironomus riparius midges, or on the respiration rate of activated sludge. For green algae, the bilastine no observed effect concentration (NOEC) was 22?mg?L?1; bilastine had no effect on zebra fish development, or on the reproduction rate of daphnids. Discussion: Bilastine NOEC values against zebra fish, algae, daphnids, and aerobic organisms in activated sludge were at least 130?000-fold greater than the calculated PECSW value. Conclusion: No environmental concerns exist from bilastine use in patients with allergic rhinoconjunctivitis or urticaria. 相似文献
6.
Leonardo Gabriel Bazzara María Laura Vélez María Eugenia Costamagna Ana María Cabanillas Laura Fozzatti Ariel Maximiliano Lucero Claudia Gabriela Pellizas Ana María Masini-Repiso 《Thyroid》2007,17(8):717-727
OBJECTIVE: Nitric oxide (NO) induces morphological and functional alterations in primary cultured thyroid cells. The aim of this paper was to analyze the direct influence of a long-term exposition to NO on parameters of thyroid hormone biosynthesis in FRTL-5 cells. DESIGN: Cells were treated with the NO donor sodium nitroprusside (SNP) for 24-72 h. MAIN OUTCOME: SNP (50-500 micromol/L) reduced iodide uptake in a concentration-dependent manner. The inhibition of iodide uptake increased progressively with time and matched nitrite accumulation. SNP inhibited thyroperoxidase (TPO) and thyroglobulin (TG) mRNA expression in a concentration-dependent manner. SNP enhanced 3',5'-cyclic guanosine monophosphate (cGMP) production. 3',5'-cyclic adenosine phosphate (cAMP) generation was reduced by a high SNP concentration after 48 h. 8-Bromoguanosine 3',5'-cyclic monophosphate (8-Br-cGMP), a cGMP analog, inhibited iodide uptake as well as TPO and TG mRNA expression. The cGMP-dependent protein kinase (cGK) inhibitor KT-5823 reversed SNP or 8-Br-cGMP-inhibited iodide uptake. Thyroid-stimulating hormone pretreatment for 24-48 h prevented SNP-reduced iodide uptake although nitrite levels remained unaffected. CONCLUSION: These findings favor a long-term inhibitory role of the NO/cGMP pathway on parameters of thyroid hormone biosynthesis. A novel property of NO to inhibit TPO and TG mRNA expression is supported. The NO action on iodide uptake could involve cGK mediation. The long-term inhibition of steps of thyroid hormonogenesis by NO could be of interest in thyroid pathophysiology. 相似文献
7.
Luca Micci Emily S. Ryan Rémi Fromentin Steven E. Bosinger Justin L. Harper Tianyu He Sara Paganini Kirk A. Easley Ann Chahroudi Clarisse Benne Sanjeev Gumber Colleen S. McGary Kenneth A. Rogers Claire Deleage Carissa Lucero Siddappa N. Byrareddy Cristian Apetrei Jacob D. Estes Jeffrey D. Lifson Michael Piatak Jr. Nicolas Chomont Francois Villinger Guido Silvestri Jason M. Brenchley Mirko Paiardini 《The Journal of clinical investigation》2015,125(12):4497-4513
Despite successful control of viremia, many HIV-infected individuals given antiretroviral therapy (ART) exhibit residual inflammation, which is associated with non–AIDS-related morbidity and mortality and may contribute to virus persistence during ART. Here, we investigated the effects of IL-21 administration on both inflammation and virus persistence in ART-treated, SIV-infected rhesus macaques (RMs). Compared with SIV-infected animals only given ART, SIV-infected RMs given both ART and IL-21 showed improved restoration of intestinal Th17 and Th22 cells and a more effective reduction of immune activation in blood and intestinal mucosa, with the latter maintained through 8 months after ART interruption. Additionally, IL-21, in combination with ART, was associated with reduced levels of SIV RNA in plasma and decreased CD4+ T cell levels harboring replication-competent virus during ART. At the latest experimental time points, which were up to 8 months after ART interruption, plasma viremia and cell-associated SIV DNA levels remained substantially lower than those before ART initiation in IL-21–treated animals but not in controls. Together, these data suggest that IL-21 supplementation of ART reduces residual inflammation and virus persistence in a relevant model of lentiviral disease and warrants further investigation as a potential intervention for HIV infection. 相似文献
8.
Spindler A Bellomio V Berman A Lucero E Baigorria M Paz S Garrone N Torres AI Romano O Carraccio A Leal O Bazzano A Vazquez D Pera O Arquez G Valdez M Lazaro H Rengel S Acosta E Santana M 《The Journal of rheumatology》2002,29(6):1166-1170
OBJECTIVE: To ascertain the prevalence of rheumatoid arthritis (RA) in Tucumán, Argentina. METHODS: The study was conducted between January 1, 1998, and December 31, 1999, in Tucumán province in northwest Argentina. Outpatient and hospitalization medical records for all patients with RA aged > or = 16 years were reviewed. Diagnosis was by 1987 American College of Rheumatology (ACR) criteria for RA and the population data were based on the 1991 national census. Prevalence rates, with 95% CI, were calculated using the number of San Miguel de Tucumán residents who fulfilled the 1987 ACR criteria for RA as numerator, and the city population aged > or = 16 as denominator. Crude and age-specific prevalence rates were calculated as number of cases/1,000 inhabitants. RESULTS: We identified 695 cases of RA. Sex-specific and overall prevalence rates (per 1,000) were 1.97 (95% CI 1.8-2) for all, 0.6 (95% CI 0.49-0.73) for men, 3.2 (95% CI 2.9-3.5) for women. CONCLUSION: Prevalence of RA is low in residents of Tucumán, Argentina, and comparable with rates observed in epidemiological surveys from Southern European countries. 相似文献
9.
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