全文获取类型
收费全文 | 443篇 |
免费 | 8篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 22篇 |
妇产科学 | 1篇 |
基础医学 | 73篇 |
口腔科学 | 4篇 |
临床医学 | 25篇 |
内科学 | 73篇 |
皮肤病学 | 14篇 |
神经病学 | 5篇 |
特种医学 | 73篇 |
外科学 | 24篇 |
综合类 | 50篇 |
预防医学 | 14篇 |
眼科学 | 1篇 |
药学 | 63篇 |
中国医学 | 1篇 |
肿瘤学 | 15篇 |
出版年
2021年 | 2篇 |
2019年 | 4篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2014年 | 6篇 |
2013年 | 4篇 |
2012年 | 10篇 |
2011年 | 19篇 |
2010年 | 12篇 |
2009年 | 7篇 |
2008年 | 18篇 |
2007年 | 15篇 |
2006年 | 16篇 |
2005年 | 12篇 |
2004年 | 17篇 |
2003年 | 12篇 |
2002年 | 3篇 |
2001年 | 5篇 |
2000年 | 7篇 |
1999年 | 11篇 |
1998年 | 31篇 |
1997年 | 21篇 |
1996年 | 22篇 |
1995年 | 11篇 |
1994年 | 17篇 |
1993年 | 15篇 |
1992年 | 12篇 |
1991年 | 10篇 |
1990年 | 14篇 |
1989年 | 20篇 |
1988年 | 18篇 |
1987年 | 7篇 |
1986年 | 10篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 8篇 |
1980年 | 8篇 |
1979年 | 1篇 |
1978年 | 5篇 |
1977年 | 1篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1973年 | 5篇 |
1972年 | 4篇 |
1971年 | 3篇 |
排序方式: 共有458条查询结果,搜索用时 109 毫秒
1.
2.
3.
4.
5.
M Kaplan HJ Vreman C Hammerman C Leiter B Rudensky MG MacDonald DK Stevenson 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(4):455-457
The incidence (%) of hyperbilirubinemia (serum bilirubin ≥257 μmol/l) was similar in neonates with a combination of ABO incompatibility and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency (45%), with ABO incompatibility (54%) or G-6-PD deficiency (37%), alone (ns). Carboxyhemoglobin values, corrected for inspired CO, were similarly elevated in all three groups (0.87 ± 0.32%, 0.82 ± 0.29%, 0.76 ± 0.18%, respectively, ns), but correlated with bilirubin only in those with ABO incompatibility alone. ABO-incompatible/G-6-PD-deficient neonates, compared with those with either condition alone, are not at increased risk for hemolysis or hyperbilirubinemia. 相似文献
6.
Okazaki K Takada A Ito T Imai M Takakuwa H Hatta M Ozaki H Tanizaki T Nagano T Ninomiya A Demenev VA Tyaptirganov MM Karatayeva TD Yamnikova SS Lvov DK Kida H 《Archives of virology》2000,145(5):885-893
Summary. Influenza A viruses of different subtypes were isolated from fecal samples of ducks in their nesting areas in Siberia in
summer from 1996 to 1998. Phylogenetic analysis of the NP genes of the isolates in Siberia and those in Hokkaido, Japan on
their flyway of migration from Siberia to the south in autumn revealed that they belong to the Eurasian lineage of avian influenza
viruses. It is noted that the genes of the isolates in Siberia are closely related to those of H5N1 influenza virus strains
isolated from chickens and humans in Hong Kong in 1997 as well as to those of isolates from domestic birds in southern China.
The results indicate that influenza viruses perpetuated in ducks nesting in Siberia should have contributed genes in the emergence
of the H5N1 virusin Hong Kong. Vaccine prepared from avirulent A/duck/Hokkaido/4/96 (H5N3) influenza virus was potent enough
to protect mice from challenge with lethal dose of the pathogenic H5N1 virus [19]. Intensive surveillance study of aquatic
birds especially in Siberia is, therefore, stressed to provide information on the future pandemic influenza virus strains
and for vaccine preparation.
Received August 24, 1999/Accepted January 7, 2000 相似文献
7.
8.
D. K. Lvov Yu. M. Tsyrkin F. R. Karas E. M. Timopheev V. L. Gromashevski O. V. Veselovskaya N. Z. Osipova K. B. Fomina Yu. I. Grebenyuk 《Archives of virology》1973,41(3):170-174
Summary A virus strain was isolated fromVespertilio pipistrellus Schreber, 1775 while examining bats in Sokuluksk region of the Kirghiz S.S.R. in 1970. Hemagglutination inhibition tests indicated that the virus ranged among group B arboviruses. It differed essentially in complement fixation and neutralization tests from 30 viruses of the B group: Entebbe bat; Bukalasa bat; Dakar bat; Kadam; Modoc; Spondweni; Ilheus; Japanese, St. Louis, Murray Vallay and tick-borne encephalitis; Kyasanur Forest disease; Powassan; Langat; Tyuleniy; West Nile; Bussuquara; Cowbone Ridge, Uganda S; SAH-336; Kokobera; yellow fever; Dengue, types 1 and 2; Wesselsbron; Edge Hill; Alfuy; Stratford; Zika; Potuskum. It may be concluded that Sokuluk virus is a new group B virus. Complement-fixing antibodies were not found in sera of 150 cows and 200 sheep but they were detected in 0.6 percent of 579 human sera in the Kirghiz S.S.R. 相似文献
9.
Anorexia nervosa (AN) is a serious life-threatening illness that typically has its onset during the adolescent years. Evidence regarding the optimal treatment of AN in children and teenagers is growing; however, much remains unknown. Although current treatment approaches vary in Canada and elsewhere, the evidence to date indicates that family-based treatment (FBT) is the most effective treatment for children and teenagers with AN. A key component of the FBT model is that the parents are given the responsibility to return their child to physical health and ensure full weight restoration. An understanding of the basic principles and philosophy underlying FBT allows the physician to initiate elements of this evidence-based intervention to young patients with AN and their families. 相似文献
10.
Role of extracellular adenosine triphosphate in the cytotoxic T- lymphocyte-mediated lysis of antigen presenting cells 总被引:4,自引:0,他引:4
The lysis of antigen presenting cells (APCs) by cytotoxic T lymphocytes (CTLs) may be one mechanism whereby an immune response is downregulated by Staphylococcus superantigens. Disappearance of monocytes/macrophages from staphylococcal enterotoxin A (SEA)-activated peripheral blood mononuclear cell (PBMC) cultures, but not from control PBMC cultures was seen by flow cytometry. Recently, adenosine triphosphate (ATP) has been described as an effector molecule in CTL-mediated lysis of some murine tumor target cells. We have also shown that ATP caused the lysis of human macrophages, and that treatment of cells with interferon gamma (IFN gamma) rendered macrophages significantly more sensitive to ATP than untreated cells. To show that this purine nucleotide may play a role in modulating the immune system, we generated human CTLs that were stimulated with SEA, and used them as effector cells against SEA-pulsed autologous macrophages. CTLs were found to specifically lyse SEA-pulsed macrophages, while control, unpulsed, macrophages were unaffected. The addition of hexokinase, an enzyme that hydrolyzes ATP, significantly abrogated the killing of SEA-pulsed cells during the assay. In examining the mechanism of cytotoxicity, electron microscopy showed that macrophages incubated with both ATP and CTLs underwent necrosis, rather than apoptosis. From these results, it is suggested that ATP is released from CTLs during antigen presentation, and that IFN gamma- activated macrophages, which are inherently more sensitive to this mediator, are readily lysed and therefore removed from circulation, thus downregulating an immune response. 相似文献