Evaluating the psychometric properties of the EQ-5D-5L and SF-6D among patients with haemophilia

The European Journal of Health Economics - The aim of this study was to evaluate the psychometric properties of the EQ-5D-5L and SF-6D, and to compare their performance among patients living with...     

Simultaneous assessment of both lung morphometry and gas exchange function within a single breath‐hold by hyperpolarized 129Xe MRI

During the measurement of hyperpolarized ¹²⁹Xe magnetic resonance imaging (MRI), the diffusion‐weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange function of the lungs. To date, the two techniques have only been performed during separate breaths. However, the request for multiple breaths increases the cost and scanning time, limiting clinical application. Moreover, acquisition during separate breath‐holds will increase the measurement error, because of the inconsistent physiological status of the lungs. Here, we present a new method, referred to as diffusion‐weighted chemical shift saturation recovery (DWCSSR), in order to perform both DWI and CSSR within a single breath‐hold. Compared with sequential single‐breath schemes (namely the ‘CSSR + DWI’ scheme and the ‘DWI + CSSR’ scheme), the DWCSSR scheme is able to significantly shorten the breath‐hold time, as well as to obtain high signal‐to‐noise ratio (SNR) signals in both DWI and CSSR data. This scheme enables comprehensive information on lung morphometry and function to be obtained within a single breath‐hold. In vivo experimental results demonstrate that DWCSSR has great potential for the evaluation and diagnosis of pulmonary diseases.     

Single breath‐hold measurement of pulmonary gas exchange and diffusion in humans with hyperpolarized 129Xe MR

Pulmonary diseases usually result in changes of the blood‐gas exchange function in the early stages. Gas exchange across the respiratory membrane and gas diffusion in the alveoli can be quantified using hyperpolarized ¹²⁹Xe MR via chemical shift saturation recovery (CSSR) and diffusion‐weighted imaging (DWI), respectively. Generally, CSSR and DWI data have been collected in separate breaths in humans. Unfortunately, the lung inflation level cannot be the exactly same in different breaths, which causes fluctuations in blood‐gas exchange and pulmonary microstructure. Here we combine CSSR and DWI obtained with compressed sensing, to evaluate the gas diffusion and exchange function within a single breath‐hold in humans. A new parameter, namely the perfusion factor of the respiratory membrane (SVR_d/g), is proposed to evaluate the gas exchange function. Hyperpolarized ¹²⁹Xe MR data are compared with pulmonary function tests and computed tomography examinations in healthy young, age‐matched control, and chronic obstructive pulmonary disease human cohorts. SVR_d/g decreases as the ventilation impairment and emphysema index increase. Our results indicate that the proposed method has the potential to detect the extent of lung parenchyma destruction caused by age and pulmonary diseases, and it would be useful in the early diagnosis of pulmonary diseases in clinical practice.     

血浆滤过透析治疗肝衰竭合并脓毒症的疗效

目的 探讨血浆滤过透析（Plasmadiafiltration,PDF）治疗肝衰竭合并脓毒症的临床疗效。方法 回顾性分析2017年1月至2019年1月我院ICU收治的31例肝衰竭合并脓毒症患者临床资料,上述患者行PDF及抗感染等内科综合性治疗,观察治疗前后临床症状及体征的改善;观察治疗前后凝血酶原活动度(PTA)及纤维蛋白原、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、血氨及终末期肝病模型（MELD）评分变化;观察治疗前后降钙素原(PCT)、白细胞介素6(IL 6)、C反应蛋白(CRP)、血常规、乳酸及序贯性器官功能衰竭(SOFA)评分变化;观察治疗过程中的不良反应。结果 PDF治疗后临床有效率达61.29%,不良反应为8.21%;PDF 治疗前后PTA、纤维蛋白原、TBIL 、AST、Na+、K+、PCT、IL 6、CRP、白细胞(WBC)、乳酸、SOFA及MELD评分差异有统计学意义（P<0.05）。结论 PDF结合内科治疗显著改善肝衰竭合并脓毒症患者的凝血功能和肝功能,同时能清除炎症因子从而有效缓解病情。     

Review on regulation of inwardly rectifying potassium channels

An inwardly rectifying potassium channel (Kir) is a kind of protein complex that is widely expressed on excitable and nonexcitable cell membranes. Kir channels serve important roles in cellular physiology such as cell excitability and K+ homeostasis. The Kirs (KIR1-7) are regulated by many factors: phosphatidylinosital-4, 5-bisphosphate (PIP2), ATP, or G-proteins. Other factors like polyamines, kinases, pH, and Na+ ions act cooperatively to modulate Kir channels. Different types and specific distributions of KIR channels determine the diversity of regulatory mechanisms. This review provides insight into Kir channel regulation.     

回授法联合微信健康教育对后颅窝肿瘤术后吞咽困难患者康复的影响

目的 探讨回授法联合微信健康教育对后颅窝肿瘤术后吞咽困难患者康复的影响.方法 根据住院时间,将2019年1～6月行后颅窝肿瘤术后并发吞咽困难患者43例分为对照组,2019年7～12月行后颅窝肿瘤术后并发吞咽困难患者43例分为干预组.对照组采用常规方法进行健康教育;干预组采用回授法联合微信进行健康教育.于干预后1周、1个月、3个月评价干预效果.结果 干预后1周,干预组误吸发生率显著低于对照组(P＜0.05);干预后1个月、3个月干预组吞咽功能评分显著低于对照组(均P＜0.05),两组吞咽功能评分随时间延长而下降,干预组下降更明显(P＜0.05).结论 应用回授法联合微信对后颅窝肿瘤术后吞咽困难患者进行健康教育,能够有效改善患者吞咽功能、降低误吸发生率,有利于患者机体康复.     

综合医院立体交通设计研究——以浙江省台州恩泽医院为例

文章以台州恩泽医院为例,从地形地势、流线组织、交通衔接、无障碍设计、绿化景观等方面对医院立体交通设计进行详细分析,以期为医院立体交通设计提供一些借鉴和参考。     

丹红注射液结合抗菌药物对腹股沟疝术后血清MMP-2、MMP-9、TIMP-2、TIMP-1及应激指标作用机制研究

目的:研究丹红注射液结合抗菌药物对腹股沟疝术后血清MMP-2、MMP-9、TIMP-2、TIMP-1及应激指标作用。方法:回顾性分析选取的2015年1月至2017年11月河北北方学院附属第一医院收治的绞窄性疝患者152例作为研究对象,按照术后不同的用药方法分为观察组(n=75)和对照组(n=77)。在腹股沟疝手术后,对照组患者单纯给予静脉注射常规抗菌药物。观察组在对照组患者的基础上额外增加丹红注射液。记录2组包括皮质醇(Cor)、去甲肾上腺素(NE)、醛固酮(ALD)等应激指标的变化幅度,以及血清MMP-2、MMP-9、TIMP-2、TIMP-1的水平比较。结果:观察组术后应激指标Cor,NE,和ALD均显著优于对照组;观察组检测后血清MMP-2、MMP-9、TIMP-2、TIMP-1水平,与对照组患者比较,差异有统计学意义(P 0. 05);观察组检测后炎性反应因子水平IFN-γ、TNF-α、IL-2、IL-4、IL-6、IL-10水平,与对照组患者比较,差异有统计学意义(P 0. 05)。结论:丹红注射液结合抗菌药物对腹股沟疝术后恢复疗效显著,比起单纯使用抗菌药物,血清MMP-2、MMP-9、TIMP-2、TIMP-1水平、应激指标与炎性反应因子均有明显优势,值得临床广泛应用。