全文获取类型
收费全文 | 994篇 |
免费 | 84篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 17篇 |
妇产科学 | 6篇 |
基础医学 | 159篇 |
口腔科学 | 6篇 |
临床医学 | 42篇 |
内科学 | 371篇 |
皮肤病学 | 5篇 |
神经病学 | 19篇 |
特种医学 | 240篇 |
外科学 | 77篇 |
综合类 | 2篇 |
预防医学 | 64篇 |
眼科学 | 11篇 |
药学 | 37篇 |
肿瘤学 | 27篇 |
出版年
2021年 | 7篇 |
2020年 | 4篇 |
2019年 | 9篇 |
2018年 | 13篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2015年 | 7篇 |
2014年 | 20篇 |
2013年 | 26篇 |
2012年 | 47篇 |
2011年 | 39篇 |
2010年 | 22篇 |
2009年 | 24篇 |
2008年 | 33篇 |
2007年 | 41篇 |
2006年 | 42篇 |
2005年 | 49篇 |
2004年 | 30篇 |
2003年 | 26篇 |
2002年 | 30篇 |
2001年 | 35篇 |
2000年 | 23篇 |
1999年 | 31篇 |
1998年 | 28篇 |
1997年 | 32篇 |
1996年 | 24篇 |
1995年 | 20篇 |
1994年 | 25篇 |
1993年 | 27篇 |
1992年 | 17篇 |
1991年 | 13篇 |
1990年 | 13篇 |
1989年 | 26篇 |
1988年 | 30篇 |
1987年 | 35篇 |
1986年 | 24篇 |
1985年 | 21篇 |
1984年 | 24篇 |
1983年 | 20篇 |
1982年 | 15篇 |
1981年 | 22篇 |
1980年 | 16篇 |
1979年 | 6篇 |
1978年 | 13篇 |
1977年 | 6篇 |
1976年 | 7篇 |
1975年 | 4篇 |
1972年 | 3篇 |
1926年 | 5篇 |
1925年 | 23篇 |
排序方式: 共有1084条查询结果,搜索用时 234 毫秒
1.
Donor interleukin-4 promoter gene polymorphism influences allograft rejection after heart transplantation. 总被引:3,自引:0,他引:3
Femke J Bijlsma Joyce vanKuik Marcel G J Tilanus Nicolaas deJonge Erik H Rozemuller Jan G van den Tweel Frits H J Gmelig-Meyling Roel A deWeger 《The Journal of heart and lung transplantation》2002,21(3):340-346
BACKGROUND: The cytokine interleukin-4 (IL-4) is secreted mainly by activated T lymphocytes and characterizes the T-helper 2 (Th2) sub-type. In transplantation Th2 cells are believed to induce graft tolerance. Previous studies revealed that patients with a relatively high frequency of IL-4 producing helper T lymphocytes (HTL) before heart transplantation (HTX) had no or less rejection episodes compared with patients with a low frequency of IL-4 producing HTL. Three single nucleotide polymorphisms (SNPs) have been identified in the promoter region of the IL-4 gene, which influence promoter strength. We investigated whether there was a correlation between SNP genotypes in the IL-4 promoter and heart failure, and rejection after HTX. METHODS: Seventy HTX patients, 61 donors, and 36 controls were genotyped for the 3 SNPs by sequencing. RESULTS: Of the SNPs at -285 and -81, only the C and A alleles, respectively, were found in this study. Both alleles were found for the -590 SNP. No relation between patient genotype of the SNP at -590 and heart failure and rejection was found. However, incidence of rejection was significantly lower in patients that received a donor heart with the T-positive genotype compared with patients that received a heart from a T-negative donor. Patients who had the T-negative genotype and received a heart from a T-positive donor, suffered significantly less from rejection than T-negative patients that received a T-negative donor heart. This was not significant in the T-positive patient group. CONCLUSIONS: This indicates that IL-4 production within the donor heart and by cells from the donor is important for reducing incidence of episodes of rejection. 相似文献
2.
3.
4.
The 3-M syndrome is a clinically recognizable disorder characterized by prenatal and postnatal growth retardation and a spectrum of consistent minor anomalies. Intelligence seems normal. Inheritance is probably autosomal recessive, with possible expression of the mutant gene in the heterozygote. Three sibs with the 3-M syndrome are reported, together with an extensive review of the pertinent literature. 相似文献
5.
6.
Normal and diseased isolated lungs: high-resolution CT 总被引:8,自引:0,他引:8
7.
Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. 总被引:1,自引:0,他引:1
Collins CE Benson MJ Burnham WR Rampton DS 《Alimentary pharmacology & therapeutics》1996,10(3):315-320
BACKGROUND: Inflammatory bowel disease is associated with increased mucosal release of eicosanoids. Among these, thromboxane A2 has been proposed as a possible inflammatory mediator; its suppression may be a useful therapeutic option. METHODS: Using a tissue incubation technique, we compared release of immunoreactive thromboxane B2 by colonic biopsies from patients with ulcerative colitis, Crohn's disease and controls, and assessed the inhibitory effect of picotamide, a thromboxane synthesis inhibitor-receptor antagonist, which has been widely used in Italy for management of ischaemic heart and cerebrovascular disease. RESULTS: Increased amounts of thromboxane B2 were released from biopsies from patients with active ulcerative colitis (median 238 pg/20 min/mg wet weight (interquartile range 147- 325), n = 12) and active Crohn's disease (252 (174-450), 6) compared with those from patients with quiescent ulcerative colitis (95 (61- 140), 12) or Crohn's disease (105 (57-201), 13), or controls (136 (64- 206), 8). Incubation with picotamide at concentrations between 100 microM and 1 mM reduced thromboxane B2 release (IC50 890 microM). CONCLUSION: Since increased thromboxane A2 production may have pathogenetic importance, thromboxane synthesis inhibitor-receptor antagonists such as picotamide merit therapeutic trial in the management of inflammatory bowel disease. 相似文献
8.
9.
10.
Johannes W. G. Jacobs MD PhD Agnes van der Heide MD Johannes J. Rasker MD PhD Johannes W. J. Bijlsma MD PhD 《Patient education and counseling》1993,20(2-3):121-132
Chronic arthritis may have great impact on the patient but also on his or her family, relatives and friends. The assessment of the consequences of chronic arthritis and the effect of therapy not only in terms of physical, but also psychological and social dimensions deserves more attention. Functional ability and health status can be measured using a questionnaire or ‘instrument’, high-lighting important aspects not quantified with more traditional measurements. In this paper, arguments to apply such instruments more frequently are given. Health status instruments can be used not only to assess beneficial but also deleterious (side-)effects of therapeutic interventions. The properties are summarized of the most frequently used instruments assessing functional ability and health status. Many of these instruments have been evaluated sufficiently for validity and reliability; their sensitivity to detect change seems to be satisfactory. Therefore it is advisable to choose an internationally accepted, frequently used instrument, reflecting the area of interest. 相似文献