组胺H＿2受体拮抗剂对变应性鼻炎鼻粘膜超微结构的影响

组胺Ｈ＿２受体拮抗剂对变应性鼻炎鼻粘膜超微结构的影响山西医学院第一附属医院（０３０００１）杨平常，张涛源，范道生，王长生我们既往曾经报道过一组变应性鼻粘膜的超微结构观察结果［１］，发现有较多异常改变。随后，我们对该组患者用组胺拮抗剂进行了治疗，获得比...     

胆脂瘤性中耳炎开放式—期鼓室成形术

对４２例胆脂瘤性中耳炎患者施以开放式－期鼓室成形手术，术后听力提高＞１０ｄＢ（ＨＬ）有２２耳，成功率５２．３８％，本术式较易为有乳突根治术经验的耳科医师所掌握，应广泛应用。     

Effect of superantigen on ion electrophysiology and permeability in rabbit maxillary sinus epithelia

Objective Superantigens are potent inflammatory stimuli which derive from pathogenic microbes such as bacteria, viruses and protozoa. The aim of this study was to investigate the role of superantigens on the function of rabbit maxillary sinus epithelium. Methods Twenty New Zealand white rabbits were divided into 4 groups. Rabbit sinus mucosa was separated under a surgical microscope and mounted in Ussing chambers to record short circuit current, conductance and permeability to horseradish peroxidase (HRP). Group A was used as normal control. Group B was stimulated with an injection of superantigen into the sinus for 4 hours. The sinus mucosa of Group C was stimulated by the addition of tumor necrosis factor α (TNF-α) into Ussing chambers. Group D sinus mucosa was stimulated by superantigen after pretreatment with anti-TNF-α antibody. Results Superantigen evoked increases in sinus epithelial cell baseline short circuit current, conductance and permeability to HRP stimulated by the addition of TNF-α into Ussing chambers. These were similar to results from superantigen stimulation in vivo. The effect of superantigen on sinus epithelial cells could be blocked by pretreatment with anti-TNF-α antibody. Conclusions Superantigen affected the function of sinus epithelial cells, including the capability of epithelial defensive barrier, which might be mediated by TNF-α.     

天眩清治疗眩晕、耳鸣的临床观察

目的 观察天眩清注射液对周围性眩晕、神经性耳鸣的治疗效果。方法 眩晕患者120例，耳鸣患者80例，各随机分为实验组及对照组，按观察项目、评定标准进行系列临床观察。结果 两实验组病例中，眩晕者总有效率93．3％，耳鸣者总有效率77．5％。结论 天眩清注射液对周围性眩晕、神经性耳鸣有显著疗效，为一种安全有效的制剂。     

鼻中隔矫正和筛前神经电灼联用治疗鼻中隔偏曲伴变应性鼻炎

应用鼻中隔矫正术和（或）筛前神经电灼术治疗鼻中隔偏曲伴变应性鼻炎（ＰＡＲ）患者８６例。其中，Ａ组：２４例，用筛前神经电灼术治疗；Ｂ组：２９例，行矫正鼻中隔偏曲治疗；Ｃ组：３３例。以上述两法联合治疗。各组患者术后症状均立即停止发作，术后４周进行鼻粘膜抗原激发试验，得分均显著低于术前。术后１～２年随访，Ａ、Ｂ组都有少数病例复发，而Ｃ组无一例复发；术后５年随访Ａ、Ｂ组均有６０％的病例复发，而Ｃ组的复发率仅１２．５％。表明鼻中隔矫正术和筛前神经电灼术联用治疗鼻中隔偏曲伴ＰＡＲ，是一种较为理想的方法。     

光导纤维镜下声带息肉切除术

报告粘膜表面麻醉下采用光导纤维鼻咽喉镜，施行声带息肉切除术３０７例。其中２００例在术后２周至半年左右复查，结果９５％以上发声恢复正常或明显好转，文中介绍了光导纤维镜下手术的方法及有关体会。     

窦口鼻道复合体疏通术对鼻纤毛输运功能的影响

对８９例经多种保守治疗效果不佳、窦口鼻道复合体（ＯＣ）均有不同病变的鼻窦炎患者，在内窥镜下行ＯＣ疏通术。术前和术后分别测定了鼻纤毛的输运功能，术前鼻纤毛输运功能下降，术后得到不同程度的恢复，相关分析结果表明，鼻纤毛输运功能与鼻甲肿大程度呈负相关关系。     

经鼻泪管前后径路行上颌窦内窥镜手术

经鼻泪管前后径路行上颌窦内窥镜手术杨平常刘涛张涛源范道生王长生我科采用经鼻泪管前、后径路行上颌窦内窥镜手术３８例（３８侧），由于进入上颌窦的位置靠前，方便了手术操作，且能保存鼻腔、鼻窦的正常解剖和生理功能，符合功能性鼻内窥镜的手术原则［１］，现报道如...