OBSERVATIONS ON DELAYED EMBRYOTOXIC AND TERATOGENIC EFFECTS GF DL-111-IT, A NEW SYNTHETIC PREGNANCY-TERMINATINGAGENT IN RATS

DL-111-IT, a new pregnancy-terminating agent, was synthesized in our laboratory. Its subcutaneous ED50 for termination of early pregnancy was found to be 0.29±0.08 mg/ kg/d × 5d or 11.5± 1.3 rag/kg in single dose. The present paper deals with the delayed emhryotoxic and teratogenic effects ofDL-111-IT on fetuses of the next litter in rats.     

TOXICOLOGICAL STUDR OF DL-111-IT,A NEW NON-STEROID EARLY PREGNANCY TERMINATING AGENT

DL-111-IT (3-ethylpheny1-5- (3-methoxyphenyl) -1, 2, 4-triazole) is highly effective for terminating early pregnancy in several species of animals without delayoel embryotoxic and teratogenic effects on the secondary embryo in rats. The present paper is a toxicological study of DI-111-IT.