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鸦胆子油治疗尖锐湿疣的活性成分药理研究 总被引:3,自引:0,他引:3
目的 :从鸦胆子油中提取分离对尖锐湿疣有活性的成分。方法 :采用溶剂萃取和硅胶柱层析分离 ;体外抑菌、抑滴虫试验观察抗菌、抗滴虫作用 ;小鼠皮下注射组胺观察对瘙痒的影响 ;热板法观察对小鼠的镇痛作用 ;用巴豆油致小鼠耳廓肿胀观察抗炎作用。结果 :鸦胆子油部分Ⅱ ,Ⅲ对金黄色葡萄球菌、大肠杆菌、绿脓杆菌、白色念珠菌、溶血性链球菌、淋球菌都具有较强的抗菌作用和较强的抗阴道滴虫作用 ;并具有一定的镇痛、止痒、抗炎作用。结论 :鸦胆子油中部分Ⅱ ,Ⅲ为其治疗尖锐湿疣的活性成分 相似文献
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Effect of Matrine on Human Ether à go-go Related Gene (HERG) Channels Expressed in Chinese Hamster Ovary Cells 下载免费PDF全文
Objective: To observe the effect of matrine on human ether à go-go related gene (HERG) potassium channels expressed in Chinese hamster ovary (CHO) cells and investigate whether HERG channel is a new target of the pharmacological effect of matrine on arrhythmia and tumor. Methods: HERG channel potassium current in CHO cell was recorded using whole-cell patch-clamp technique, and the influence of matrine on the current was explored. Results: Matrine inhibited HERG potassium current in a dose-dependent manner, and the 50% inhibitory concentration (IC50) was 411±23 μmol/L. Matrine had no significant effect on the activation kinetics, and mainly blocked HERG channels in their closed state. Conclusions: The blocking effect of matrine on HERG channels might be one of the mechanisms against arrythmias and tumors. Unlike most other blockers exerting blocking effect at the intracellular sites by entering the cell with the opening of HERG channel, matrine blocked HERG channels at the extracellular sites. 相似文献
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Cervical spondylosis of vertebral artery type(CSA) is a series of complicated symptoms. Vertigo is the main manifestation, caused by cerebral blood supply insufficiency due to vertebral arterial circulatory disturbance in cervical disorder. Since 相似文献
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目的观察腹针和体针结合治疗缺血性中风病的临床疗效。方法依照本研究纳入标准,采用随机数字表将入选病例分成腹针组30例、体针组31例、腹针和体针结合组31例,根据腹针理论的取穴原则,选取腹针的腧穴并使用一定的针刺手法进行治疗,对照观察神志、语言、上肢瘫、下肢瘫等症状改善情况,以及患者日常生活活动能力,分别于治疗前、治疗30次后进行临床疗效评价以及日常生活活动量表(ADL)评分。结果 3组治疗前后比较皆有显著性差异,腹针组与体针组之间比较疗效无显著性差异(P>0.01)。腹针和体针结合组疗效以及ADL评分均优于其他2组(P<0.01)。结论认为腹针是一种治疗中风病的有效针刺方法,疗效与体针相当,但腹针与体针结合能更好地改善中风急性期和恢复期气虚阴虚患者神志、语言、肢体运动功能状态,提高临床疗效,改善患者ADL评分。 相似文献
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目的:观察电针调理髓海治疗多系统萎缩4例的临床疗效。方法:电针上印堂、风府、百会、太阳、神庭、头维。每天针灸1次,每周治疗5次,1个月为1个疗程,共治疗1个疗程。结论:电针调理髓海能明显改善患者症状,提高患者的生存质量。 相似文献
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