The Effect of Ligustrazine on Peritoneal Transport in Peritoneal dialysis

In order to investigate the effect of ligustrazine (Lig)i.p.on peritoneal permeability in peritoneal dialysis and its side effects,creatinine was given intravenously and continuously to maintain the high plasma creatinine level.All the rabbits were divided into three groups:normal control group (goup A),group B treated with 0.12% Lig and group C treated with 0.24% Lig.The peritoneal dialysis of all rabbits lasted 2h.The plasma and dialysate levels of glucose,protein and creatining were observed immediate,30min,60min,90min,120min after dialysis.Creastinine dialysate/plasma ratio (D/P),protein D/P ratio,grucose D/Do at different time points after dialysis and creatinine mass transfer area coefficient (MTAC) at 120min were calculated.The structures of peritoneum were observed under optical microscope and electron microscope after continuously intraperitoneal injection of Lig for 14 days.The results showed that the 90-min and 12-min creatinine D/P ratios in the group C were higher than in the group A.The 120-min creatinine MATC in the group C was higher than in the group A.The rabbits treated with Lig did not show significant structure changes of peritoneum and signs of peritoneal irritation.It was suggested that Lig could increase mass transfer ability of peritoneum without significant side effects.     

川芎嗪注射液对腹膜透析溶质转运的影响

近年来，随着腹膜透析（ＰＤ）装置的不断改进，ＰＤ并发感染的发生率已明显下降，而腹膜溶质转运障碍等原因所致透析不充分的问题日益突出，因此如何增加 ＰＤ时腹膜对溶质清除，减少蛋白质的丢失，成为目前急待研究与解决的问题。我们通过观察中药川芎嗪对腹膜溶质转运的影响，以期为其预防及改善腹膜转运障碍提供理论依据。 一、材料与方法 （一）实验动物：１８只新西兰大白兔体重 ２． ０～２． ５ ｋｇ，由本院动物实验中心提供。 （二）实验方法： １．分组：每只大白兔按随机分组的原则分为３组，Ａ组单纯用１．５％ Ｂａｘｔｅｒ腹…