鼻腔鼻窦恶性纤维组织细胞瘤1例报告

患者男,33岁。头痛及鼻出血1个月。头痛以前额较重,夜间明显,不能入眠。右面部及牙龈麻木,右耳阵发性疼痛,右侧眼球突出,眼睑肿胀,复视,睁眼受限。体检:外鼻无畸形,鼻窦区无压痛,鼻黏膜轻度充血,双侧下鼻甲稍肥大。鼻内镜:右侧鼻腔有坏死出血组织,去除坏死组织,见暗红色新生物来自嗅裂,鼻咽大部也有新生物充填。胸部X线检查及心电图无异常,化验检查无异常。影像学检查:(1)CT检查,轴位及冠状位平扫,右侧鼻腔上部软组织密度肿物,CT值49HU,较均匀,向上及向前侵犯同侧后组筛窦、右侧眶尖、蝶窦,蝶骨体及右侧蝶骨大、小翼内侧部分骨质破坏(图1…     

鳞状细胞癌抗原在肺癌诊断和预后方面的意义

在过去几年中,已发现许多具有潜在使用价值的肿瘤标记。就肺癌而言,小细胞肺癌有数种敏感性和特异性都较好的标记,如神经元特异性烯醇化酶、B-B肌酸激酶等。但对非小细胞肺癌,已知的标记物(主要是癌胚抗原,CEA)不够敏感。特异性亦差。最近,一些作者研究了鳞状细胞癌抗原(SCCAg)在肺癌诊断及临床     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

多中心性肠系膜纤维瘤病临床病理分析(附1例报告)

肠系膜纤维瘤病(mesenteric fibromatosis,MF),也称为韧带样型纤维瘤病,是发生在肠系膜的腹腔内纤维瘤的一个非常少见的亚型,以浸润性生长和易于局部复发为特征,但不转移[1]。本文诊断多中心性肠系膜纤维瘤病1例,并复习文献报告如下。患者,女性,38岁。因腹腔肿物11d,在当地医院     

甲状腺影像报告和数据系统联合BRAF V600E突变检测对甲状腺细针穿刺细胞学不确定结节的诊断价值

目的探讨甲状腺影像报告和数据系统(TIRADS)联合BRAF V600E突变检测对甲状腺细针穿刺细胞学(FNAC)不确定结节的诊断价值, 并分析TIRADS分类在筛选需行BRAF V600E突变检测结节中的作用。方法回顾性分析河北医科大学第二医院2018年1月至2021年8月经TIRADS分类、FNAC Bethesda分类、BRAF V600E突变检测和术后组织病理学诊断的337例甲状腺结节患者的临床病理资料。分析TIRADS分类、FNAC Bethesda分类及BRAF V600E突变单独及联合检测在鉴别甲状腺结节良恶性中的作用。结果以术后组织病理学检查结果为金标准, TIRADS分类、FNAC Bethesda分类和BRAF V600E突变检测诊断甲状腺癌的灵敏度分别为76.0%、88.1%和80.4%, 特异度分别为84.0%、96.0%和100.0%。59例FNAC不确定结节中, 37例(62.7%)术后组织学证实为恶性结节。BRAF V600E突变检测对FNAC不确定结节诊断的灵敏度和准确度分别为51.4%和69.5%, 而BRAF V600E突变检测联合TIRADS分类的...     

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病例女,28岁。腹部不适1年,发现肿物1天。患者1年前无明显诱因出现腹部隐痛不适,无放射痛、恶心、呕吐。PE:右上腹可触及一约8cm×5cm×5cm肿物,表面光滑,界限不清,无压痛,活动度差。实验室检查及胸部X线检查未见异常。妇科B超示子宫腺肌瘤。腹部B超示右腹膜后可探及23.6cm×10     

重症肌无力患者胸腺CT与病理学检查结果对照

本研究对2000～2003年在我院行胸腺切除手术治疗的29例重症肌无力(MG)患者的胸腺CT与胸腺病理学检查结果进行对比分析,探讨胸腺CT对胸腺病变的诊断价值. 1 临床资料 1.1 一般资料本组男13例,女16例;年龄2～67岁,平均29.8岁;病程10 d～5年,平均9个月.