银杏达莫注射液治疗急性加重期肺心病30例分析

2001年10月至2002年6月,我们对30例肺心病急性加重期患者采用银杏达莫注射液治疗。现报告如下。 临床资料:本文62例急性加重期肺心病患者,均符合全国肺心病会议制定的诊断标准。随机分为两组,治疗组30例,男18例、女12例,年龄50～83岁、平均(52.1±11.7)岁;对照组32例,其性别、年龄、临床资料与治疗组均无差异。 治疗方法:对照组采用抗感染、解痉、平喘、止咳、化痰、扩血管等常规治疗。治疗组在此基础上加用银杏达莫注射液静脉滴往,每日15ml,半个月为一个疗程。治疗前后用彩色多普勒超声心动图检测患者的肺动脉压力指标,包括肺动脉血流     

阿托伐他汀对急性脑梗死患者血清hs—CRP、IL-6、IL-10及神经功能缺损的影响

目的观察阿托伐他汀对急性脑梗死（ACI）患者血清超敏c-反应蛋白（hs—CRP）、白细胞介素-6（IL-6）、白细胞介素-10（IL-10）以及神经功能缺损的影响,探讨其抗炎作用机制。方法将90例ACI患者随机分为阿托伐他汀组45例和常规治疗组45例。阿托伐他汀组在常规治疗基础上加用阿托伐他汀20mg,每日1次,连服4周。治疗前后检测血清hs—CRP、IL-6和IL-10含量,并进行神经功能缺损程度评分（NDS）评定。另选同期健康查体正常者20例为正常对照组。结果ACI患者较健康对照组血清hs—CRP、IL-6显著升高,IL-10显著下降（P〈0．05）;两组ACI患者治疗前hs—CRP、IL-6和IL-10差异无统计学意义（P〉0．05）,治疗4周后阿托伐他汀组hs—CRP、IL-6较常规治疗组明显下降,而IL-10明显升高（P〈0．05）。此外,阿托伐他汀组治疗后NDS评分较常规治疗组显著升高（P〈0．05）。结论ACI患者较健康者血清hs—CRP、IL-6水平升高,IL—10水平下降。阿托伐他汀能明显降低ACI患者血清hs—CRP、IL-6水平,升高血清IL—10水平,有助于ACI患者的神经功能恢复,具有减轻炎症反应的神经保护作用。     

血塞通注射液治疗椎-基底动脉供血不足38例临床观察

目的观察血塞通注射液治疗椎-基底动脉供血不足的临床疗效。方法将患者75例随机分成治疗组38例，对照组37例，治疗组每日静滴血塞通注射液，对照组每日静滴丹参注射液，对比观察临床疗效。结果治疗组效果优于对照组（P〈0．05）。结论血塞通注射液可作为椎基底动脉供血不足临床常规治疗药物。     

血清白细胞介素及肿瘤坏死因子水平与急性脑梗死关系的研究

目的 探讨急性脑梗死患者血清白细胞介素6(IL-6)、IL-8和肿瘤坏死因子α(TNF-α)水平的变化及与急性脑梗死的关系.方法 选择急性脑梗死患者90例,按梗死体积及神经功能缺损程度进行分组,采用酶联免疫吸附法检测血清IL-6、IL-8和TNF-α水平并与30例对照组比较.结果 脑梗死组IL-6、IL-8和TNF-α水平[(158.4±25.8)ng/L、(168.3±18.8)ng/L、(2.9±1.0)μg/L]明显高于对照组[(68.8±5.8)ng/L、(62.3±7.5)ng/L、(0.8±0.2)μg/L],2组比较差异有统计学意义(P＜0.05).小梗死组、中梗死组、大梗死组患者血清IL-6、IL-8和TNF-α水平依次逐级升高,组间比较差异有统计学意义(P＜0.05);轻型组、中型组、重型组患者血清IL-6、IL-8和TNF-α水平逐渐升高,组间比较差异有统计学意义(P＜0.05).结论 血清IL-6、IL-8和TNF-α水平与脑梗死体积及临床神经功能缺损程度密切相关,检测IL-6、IL-8和TNF-α有助于急性脑梗死患者病情及预后的判断.

Abstract：

Objective To investigate the relationship among the serum levels of IL-6,IL-8,TNF-α and acute cerebral infarction (ACI). Methods Ninty patients with ACI were divided into different groups according to the size of infarction and clinical neurologic impairment degree score. The serum level of IL-6,IL-8 and TNF-αwere detected by enzyme-linked immunosorbent assay (ELISA). Results The serum IL-6,IL-8 and TNF-α levels in the patients with ACI within 72 hours after the onset were significantly higher than those in the healthy subjects (P＜0.05). The serum levels of IL-6,IL-8 and TNF-α increased with the volume of infarction and the differences between the groups were significant (all P＜0.05). The serum levels of IL-6,IL-8 and TNF-α increased with the clinical neurologic impairment degree score and the differences among the groups were significant (all P＜0.05).Conclusions The serum levels of IL-6,IL-8 and TNF-α increase closely with the volume of infarction and the clinical neurologic impairment degree score,which suggests that IL-6,IL-8 and TNF-α may play an important role in the pathogenesis of ACI,and probably be a prognostic factor of ACI.     

小剂量甘露醇与速尿交替应用降低颅内压效果观察

2003年5月～2005年6月，我们交替应用小剂量甘露醇与速尿治疗重症脑卒中50例，疗效较好。现介绍体会如下。