Role of oxidative stress,angiogenesis and chemo-attractant cytokines in the pathogenesis of ischaemic protection induced by remote ischaemic conditioning: Study of a human model of ischaemia-reperfusion induced vascular injury

Aims

We explored the effect of remote ischaemic conditioning (RIC) on endothelial function and on circulating mediators.

Basismaßnahmen zur Wiederbelebung Erwachsener (Basic Life Support)

Notfall + Rettungsmedizin - Der Europäische Rat für Wiederbelebung hat diese Leitlinie – Basismaßnahmen zur Wiederbelebung – auf Grundlage des...     

Learning effect of a novel interactive basic life support CD: the JUST system

INTRODUCTION: Electronic interactive learning environments can enhance the learning experience and may prove beneficial in basic life support (BLS) training. As part of the European Union funded project "JUST-in-time health emergency interventions-training of non-professionals by virtual reality and advanced IT tools", an innovative interactive CD-ROM on BLS and other emergency medicine topics was developed. We hypothesised that individuals without previous BLS training could learn CPR techniques from this CD. METHODS: Sixty-two students were randomised into a group studying the JUST CD in a computer class room for up to 60 min, and a control group who did not receive any training (serving as a reference). CD users also completed a satisfaction questionnaire immediately after studying the CD. The BLS skills of both groups were assessed in a mock BLS scenario on a training manikin. BLS performance was video recorded and analysed. RESULTS: After studying the CD for a mean period of 42 min, users of the CD had better assessment skills and were more likely to show a positive helping attitude, but chest compression and breathing techniques were ineffective. Most users rated the CD as very good and a positive learning tool. CONCLUSION: Individuals without prior BLS training showed improved behaviour and assessment skills after exposure to the CD, but motor skill acquisition requires alternative learning strategies.     

Unreliable post event report from an automated external defibrillator

Medical supervision of the use of automated external defibrillators (AEDs) is possible by the incorporation of a solid state memory system recording electrocardiography (ECG) tracings and information about the operation of the device. Since a post event report suggested inappropriate AED use erroneously, the information storage and printing processes of the Laerdal® AED system were investigated. This analysis strongly suggests (yet unpredictable) incompatibilities between the software built in the solid state memory modules and the different components of the printing system. Although no problems were encountered during the resuscitation attempts, these findings may be clinically relevant because an unreliable post event report from a solid state memory module may lead to erroneous criticism of an AED user.

Abstract

A supervisão médica do uso de desfibrilhadores automáticos externos (DAE) é possível através da incorporação de sistemas de memória permanente que gravam os traçados electrocardiográficos (ECG) e fornecem informação sobre o funcionamento do aparelho. Desde que um relato post-incidente sugeriu erradamente uma utilização inadequada do DAE, foram investigados os processos de impressão e armazenamento de informação do sistema DAE Laerdal. Esta análise sugere fortemente (mas não permite prever) a existência de incompatibilidades entre o software dos sistemas de memória e os componentes do sistema de impressão. Apesar de não terem sido detectados problemas em reanimações, estes achados podem vir a ter significado clínico relevantes já que relatos post-incidente de um módulo de memória, pouco fiáveis, podem provocar críticas erradas quanto á utilização de um DAE.     

Estimation of risk based on biological dosimetry for patients treated with radioiodine.

A multicentre study was undertaken to assess the cytogenetic damage to peripheral blood lymphocytes in 31 patients treated with 131I for thyrotoxicosis using the cytokinesis-blocked micronucleus assay. The results were compared to those for eight thyroid carcinoma patients using the same method. For each patient, blood samples were taken immediately before and 1 week after iodine administration. The first blood sample was divided into three fractions and each fraction was subsequently irradiated in vitro with 0, 0.5 and 1 Gy 60Co gamma rays, respectively. After blood culture for 70 h, cells were harvested, stained with Romanowsky-Giemsa and the micronuclei scored in 1000 binucleated cells. For both patient groups, a linear-quadratic dose-response curve was fitted through the data set of the first blood sample by a least squares analysis. The mean increase in micronuclei after 131I therapy (second blood sample) was fitted to this curve and the mean equivalent total body dose (ETBD) calculated. Surprisingly, in view of the large difference in administered activity between thyroid carcinoma patients and thyrotoxicosis patients, the increase in micronuclei after therapy (mean +/- S.D.: 32 +/- 30 and 32 +/- 23, respectively) and the equivalent total body dose (0.34 and 0.32 Gy, respectively) were not significantly different (P > 0.1). The small number of micronuclei induced by 131I therapy (32 +/- 29), compared with external beam radiotherapy for Hodgkin's disease (640 +/- 381) or cervix carcinoma (298 +/- 76) [1], gave a cancer mortality estimate of less than 1%. This also explains why late detrimental effects in patients after 131I treatment have not been reported in the literature.