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Ross BD; Jacobson S; Villamil F; Korula J; Kreis R; Ernst T; Shonk T; Moats RA 《Radiology》1994,193(2):457
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M BOTTO E THEODORIDIS E M THOMPSON H L C BEYNON D BRIGGS D A ISENBERG M J WALPORT K A DAVIES 《Clinical and experimental immunology》1996,104(2):264-268
An allotypic variant of FcγRIIa, FcγRIIa-HR (FcγRIIa-R131), has been shown in vitroto reduce the capacity of phagocytic cells to bind and internalize IgG-containing immune complexes. Our aim was to determine whether this allotypic variant was associated with susceptibility to SLE and the development of lupus nephritis, as previous studies have suggested. FcγRIIA genotype analysis was performed by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) in 215 Caucasoid, 70 Afro-Caribbean, and 46 Chinese patients with SLE, and in 259, 77, and 49 ethnically matched controls, respectively. Distribution of FcγRIIa genotypes between the patients and ethnically matched controls was not significantly different in the three populations studied. No association between the FcγRIIa-HR allotype and nephritis was found. Our results suggest that the FcγRIIa-HR allotype is not a major factor predisposing to the development of SLE, or to lupus nephritis. 相似文献
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Anti-centromere antibodies (ACA) in systemic sclerosis patients and their relatives: a serological and HLA study 下载免费PDF全文
N. J. MCHUGH J. WHYTE C. ARTLETT D. C. BRIGGS C. O. STEPHENS N. J. OLSEN N. G. GUSSEVA P. J. MADDISON C. M. BLACK K. WELSH 《Clinical and experimental immunology》1994,96(2):267-274
Autoantibody reactivity to centromere proteins CENP-A, CENP-B and CENP-C was examined in 58 patients with systemic sclerosis (SSc). 218 first degree relatives and 22 spouses, HLA class II typing for HLA-DRB1 and HLA-DQA1 was performed by restriction fragment length polymorphism (RFLP) analysis in 50 families, and HLA-DRB1, HLA-DQA1 and HLA-DQB1 typing was performed by olignucleolitde typing in 44 families. Eleven probands and two relatives had ACA. The two relatives with ACA also had SSc. One relative was an identical twin sister of a pro band with ACA and the other relative was a sister of a proband with ACA. All ACA-positive probands and relatives were female, and all recognized CENP-A, CENP-B and CENP-C. The presence of at least one HLA-DQB1 allele not coding for leueine at position 26 of the first domain appeared necessary, although not sufficient for the generation of ACA, Therefore within SSc families ACA is strongly associated with female gender and disease phenotype, and is at least in part genetically determined. 相似文献
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TELOMERE REDUCTION IN SCLERODERMA PATIENTS: A POSSIBLE CAUSE FOR CHROMOSOMAL INSTABILITY 总被引:2,自引:0,他引:2
ARTLETT C. M.; BLACK C. M.; BRIGGS D. C.; STEVENS C. O.; WELSH K I. 《Rheumatology (Oxford, England)》1996,35(8):732-737
We have hypothesized that the chromosomal instability observedin scleroderma patients and their family members may resultfrom the loss of long stretches of the telomeric repeat whichis found at the ends of all linear chromosomes. We examinedthe telomere lengths in scleroderma (SSc) patients (n = 43),their family members (n = 182) and in age-matched controls (n= 96) using restriction fragment length polymorphism (RFLP)and chemiluminescent labelled probes. The average loss of telomericDNA in SSc patients and family members was found to be 3 kbwhen compared to the controls. This loss was not related toage or the duration of the disease. These results may reflecta genetic predisposition for chromosomal instability in thesefamilies, or exposure to a common environmental agent. A widevariety of common environmental agents are known to producechromosomal aberrations; these include fungicides, pesticides,air pollutants and drugs. Scleroderma-like syndromes may beinduced by some of these agents. KEY WORDS: Chromosomal instability, Scleroderma, Telomere 相似文献
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BD White A Kong E Khoo AM Southcott 《Journal of Medical Imaging and Radiation Oncology》2005,49(4):319-321
Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease characterized by the presence of osseous and cartilaginous submucosal nodules projecting into the tracheobronchial tree. Most cases are asymptomatic and discovered incidentally at post‐mortem. We identified a case of TO on thoracic spiral CT and confirmed the diagnosis on bronchoscopy. This article reviews the imaging characteristics of TO, and shows the 3‐D virtual bronchoscopic and multiplanar reconstruction appearances of TO. 相似文献
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WBG Macdonald AP Patrikeos RI Thompson BD Adler AA Van Der Schaaf 《Journal of Medical Imaging and Radiation Oncology》2005,49(1):32-38
The present study compared the accuracy of ventilation perfusion scintigraphy (VQS) and CT pulmonary angiography (CTPA) for the diagnosis of pulmonary embolism. This was a prospective observational study of 112 patients with suspected pulmonary embolism (PE) who could be studied with both investigations within 24 h. Results were compared to final diagnosis at completion of 6-month follow up, using receiver operating characteristic (ROC) analysis. Pulmonary embolism was diagnosed in 27 referred patients (24%). The sensitivity and specificity of VQS and CTPA were similar to that reported from the literature. A normal VQ scan had the highest negative predictive value (100%), while a high-probability VQ scan had the highest positive predictive value (92%). There was no overall difference (area under the ROC curve (AUC)) between VQS (AUC (95% CI) = 0.82 (0.75,0.89)) and CTPA (AUC = 0.88 (0.81,0.94)) for the diagnosis of PE. Among patients with abnormal chest X-rays, CTPA (AUC 0.90 (0.83,0.97)) appeared somewhat better than VQS (AUC 0.78 (0.68,0.88)) but this difference did not reach statistical significance. In this instance, CTPA is at least as accurate as VQS and may provide an opportunity to make alternative diagnoses. 相似文献
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