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目的:检测Claudin-3在前列腺癌中的表达情况,探讨其与前列腺癌发生发展的关系。方法:采用组织芯片技术构建包含64例前列腺癌和39例前列腺增生组织的64点阵石蜡组织芯片,用免疫组化sP法检测该芯片中Claudin-3的表达,分析其与前列腺癌Gleason评分和临床分期的关系。结果:前列腺癌Claudin-3阳性表达率为60.94%(39/64),前列腺增生表达率17.95%(7/39)(P〈0.05);Claudin-3与前列腺癌Gleason评分和临床分期明显相关。结论:Claudin-3异常表达与前列腺癌发生发展有密切关系。 相似文献
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目的:探讨BPH患者组织学前列腺炎与PSA、前列腺体积、PSA密度(PSAD)、IPSS、最大尿流率(Qmax)及残余尿量(PVR)的相关性。方法:手术切除或经尿道前列腺电切术(TURP)治疗的BPH患者673例。按照是否伴有组织学前列腺炎将患者分为两组:A组:BPH伴组织学前列腺炎;B组:BPH不伴有组织学前列腺炎。比较两组患者PSA、前列腺体积、PSAD、IPSS、Qmax及PVR。结果:A组PSA水平为(5.64±2.48)μg/L,前列腺体积(43.66±13.11)ml,PSAD 0.129±0.048,IPSS(24.72±5.39)分,Qmax(6.94±3.23)ml/s,PVR(124.90±49.80)ml;B组PSA水平为(4.97±1.99)μg/L,前列腺体积(40.41±11.44)ml,PSAD 0.123±0.034,IPSS(23.40±6.21)分,Qmax(7.75±3.52)ml/s,PVR(112.73±50.03)ml。A组PSA水平、前列腺体积、IPSS和PVR均明显高于B组(P<0.05);A组Qmax明显低于B组(P<0.05);PSAD两组间差异无统计学意义(P>0.05)。结论:组织学前列腺炎能明显增加患者的PSA水平、前列腺体积、IPSS和PVR,降低患者Qmax。但是组织学前列腺炎与PSAD无关;组织学前列腺炎是影响BPH临床进展的重要因素。 相似文献
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Objective :To explore the main influencing factors and clinical significance of the recurrence of non-muscle invasive bladder cancer (NMIBC). Methods: Two hundred and fourteen patients with NMIBC were retrospectively reviewed in single center. Gender, age,BMI ,hypert-ension,diabetes,tumor size, tumor number, tumor grade, tumor stage, immediately intravesical instillation and intravesical chemotherapy were predicted to be the risk factors.Survival analysis was carried out by employing Kaplan-Meier and Cox proportional hazard model. Results: Finally 214 patients with NMIBC were studied, with mean age of 68.5 years at presentation, and male to female ratio was 1.4∶1. Based on 8-48 months of following up, 63(29.3%) of 214 cases had recurrence .Univariate analysis indicated that number, size, grade and stage of tumor and immediate intravesical instillation were significantly associated with the recurrence of NMIBC (all P<0.05). Number, size, grade and stage of tumor and immediate intravesical instillation were independent risk factors for recurrence of NMIBC. Conclusion: number, size, grade and stage of tumor are the independent risk factors for recurrence of NMIBC. Immediate intravesical instillation is protective for recurrence of NMIBC. 相似文献
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目的探讨活检前血清炎症标志物对前列腺活检阳性结果的预测价值, 建立基于活检前炎症指标联合其他参数的列线图模型, 并评价其对前列腺穿刺结果的预测能力。方法回顾性分析天津医科大学第二医院2019年8月至2021年8月收治的601例行经会阴前列腺穿刺活检患者的临床资料。中位年龄68(35, 89)岁。中位tPSA 9.56(4.01, 19.95)ng/ml。中位fPSA 1.36(0.88, 2.02)ng/ml。中位PSAD 0.16(0.11, 0.26)ng/ml2。中位血小板淋巴细胞比值(PLR)129.90(98.95, 169.89)。PI-RADS v2.1评分<3分189例(31.45%), 3分174例(28.95%), 4分190例(31.61%), 5分48例(7.99%)。采用简单随机分组法将患者分为建模组421例(70%), 验证组180例(30%)。两组间的临床资料比较差异均无统计学意义(P>0.05)。对建模组进行单因素和多因素logistic回归分析, 筛选预测前列腺活检阳性结果的独立影响因素, 建立列线图模型并进行内部验证。在验证组中对该模型进... 相似文献
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