排序方式: 共有14条查询结果,搜索用时 375 毫秒
1.
Comparison of risk stratification with pharmacologic and exercise stress myocardial perfusion imaging: A meta-analysis 总被引:2,自引:0,他引:2
Navare Sachin M. Mather Jeff F. Shaw Leslee J. Fowler Michael S. Heller Gary V. 《Journal of nuclear cardiology》2004,11(5):551-561
BACKGROUND: Although pharmacologic stress myocardial perfusion imaging (MPI) and exercise stress MPI have comparable diagnostic accuracy, their comparative value for risk stratification of patients with known or suspected coronary disease is not known. METHODS AND RESULTS: The data of 14,918 patients were combined from 24 studies evaluating prognosis in patients undergoing either pharmacologic stress or exercise stress MPI. Studies were included if a 2 x 2 table for hard cardiac events (cardiac death and myocardial infarction [MI]) could be constructed from the data available. Excluded were studies performed for post-MI, post-revascularization, or preoperative risk stratification. A weighted t test was used to compare the cardiac events, and a random effects model was used to calculate summary odds ratios. Summary odds ratios for hard cardiac events were similar for pharmacologic stress and exercise stress MPI. Summary receiver operating characteristic curves also showed no difference in discriminatory power between the stressors. The cardiac event rates were significantly higher with normal and abnormal test results with pharmacologic stress MPI than with exercise stress MPI (1.78% vs 0.65% [P < .001] for normal results and 9.98% vs 4.3% [P < .001] for abnormal results). Subgroup analysis revealed that both cardiac death and nonfatal MI were significantly higher with pharmacologic stress MPI. Patients undergoing pharmacologic stress MPI had a significantly higher prevalence of poor prognostic factors, and meta-regression revealed that exercise capacity was the single most important predictor of cardiac events. CONCLUSIONS: This meta-analysis shows that exercise stress MPI and pharmacologic stress MPI are comparable in their ability to risk-stratify patients. However, patients undergoing pharmacologic stress studies are at a higher risk for subsequent cardiac events. This is true even for those with normal perfusion imaging results. 相似文献
2.
3.
CY Cheung EY Chan A Krasnoselsky D Purdy AT Navare JT Bryan CK Leung KP Hui JS Peiris MG Katze 《The Journal of infectious diseases》2012,206(5):640-645
H5N1 influenza viruses, which cause disease in humans, have unusually high pathogenicity. The temporal response of primary human monocyte-derived macrophages infected with highly pathogenic H5N1 and seasonal H1N1 influenza viruses was evaluated using mass spectrometry-based quantitative proteomic profiling. This was done in order to demonstrate significant perturbation of the host proteome upon viral infection, as early as 1 hour after infection. This early host response distinguished H5N1 infection from H1N1 infection, the latter inducing less of a response. The most pronounced effect was observed on the translational machinery, suggesting that H5N1 might gain advantage in replication by using the cell protein synthesis machinery early in the infection. 相似文献
4.
T. Takahiro Tsukamoto K. Morita M. Naya C. Katoh Y. Kuge H. Okamoto H. Tsutsui N. Tamaki M. Mehdi Namdar P. T. Siegrist P. Koepfli P. Tschuetscher T. F. Hany C. A. Wyss P. A. Kaufmann R. Riikka Lautamäki K. E. J. Airaksinen M. Seppänen J. Toikka M. Luotolahti E. Ball R. Härkönen J. Knuuti M. Stewart P. Nuutila H. Hamid Ghanbari B. Hassunizadeh F. Williams D. Cunningham S. Agrawal C. Machado S. Saba Y. Tekabe A. Abu-Taha L. Johnson B. A. Ban-AN Khaw G. L. Gavin Noble R. ElKoustaf S. M. Navare J. Lundbye D. Katten M. Platt A. Ahlberg G. V. Heller 《Journal of nuclear cardiology》2005,12(2):S18-S19
5.
6.
Conclusion Exercise remains the preferred stress testing modality for patients because of its ability to provide more information than
that obtained from the presence or absence of ischemia alone. A basic knowledge of the acute cardiac response to exercise
can help us to obtain the greatest amount of information from this remarkably simple testing modality. 相似文献
7.
8.
Pharmacologic stress testing with myocardial perfusion imaging has enabled patients who cannot complete adequate exercise
to undergo diagnostic and prognostic evaluation for coronary artery disease. Pharmacologic stress agents belong to two groups:
vasodilators (such as adenosine and dipyridamole), and inotropes (such as dobutamine). All have similar sensitivity (89%-91%)
and specificity (78%-86%) for the diagnosis of coronary disease. For risk stratification, the risk of future cardiac events
is related to the extent and severity of perfusion abnormalities. Pharmacologic stress testing permits risk stratification
as early as 1 to 4 days following an acute myocardial infarction, and is superior to exercise stress testing in this regard.
Similarly, it identifies patients at high risk for perioperative cardiac events prior to noncardiac surgery. This review summarizes
the current evidence available regarding the diagnostic and prognostic use of pharmacologic stress testing. 相似文献
9.
Comparison of 16-frame and 8-frame gated SPET imaging for determination of left ventricular volumes and ejection fraction 总被引:4,自引:3,他引:1
Navare SM Wackers FJ Liu YH 《European journal of nuclear medicine and molecular imaging》2003,30(10):1330-1337
Electrocardiographic (ECG) gated single-photon emission tomography (SPET) allows for simultaneous assessment of myocardial perfusion and left ventricular (LV) function. Presently 8-frame per cardiac cycle ECG gating of SPET images is standard. The aim of this study was to compare the effect of 8-frame and 16-frame gated SPET on measurements of LV volumes and to evaluate the effects of the presence of myocardial perfusion defects and of radiotracer dose administered on the calculation of LV volumes. A total of 86 patients underwent technetium-99m SPET myocardial perfusion imaging using 16-frame per cardiac cycle acquisition. Eight-frame gated SPET images were generated by summation of contiguous frames. Left ventricular end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF) were calculated from the 16-frame and 8-frame data sets. The patients were divided into groups according to the administered dose of the radiotracer and the size of the perfusion defect. Results. Sixteen frame per cardiac cycle acquisition resulted in significantly larger EDV (122±72 ml vs 115±68 ml, P<0.0001), smaller ESV (64±58.6 ml vs 67.6±59.5 ml, P<0.0001), and higher LVEF (55.3%±18% vs 49%±17.4%, P<0.0001) as compared to 8-frame SPET imaging. This effect was seen regardless of whether a high or a low dose was administered and whether or not significant perfusion defects were present. This study shows that EDV, ESV and LVEF determined by 16-frame gated SPET are significantly different from those determined by 8-frame gated SPET. The radiotracer dose and perfusion defects do not affect estimation of LV parameters by 16-frame gated SPET.Disclosure: Frans J.T. Wackers and Yi-Hwa Liu, through an arrangement with Yale University School of Medicine (New Haven, Conn.), receive royalties from the sale of Wackers-Liu CQ software. 相似文献
10.
F. Francois Rouzet P. Lim L. Sarda-Mantel S. Bleichner-Pérez D. Lasalmonie M. Slama A. Cohen-Solal D. Le Guludec W. Acampa L. Spinelli M. Petretta F. De Lauro F. Ibello A. Alberto Cuocolo R. C. C. Wong H. C. Wong F. Azizi S. K. Wong K. T. Kheng-Thye Ho G. Gautam Ramakrishna T. D. Miller J. F. Breen P. A. Araoz D. O. Hodge RJ. Gibbons S. Sachin Navare G. Noble D. Katten A. Ahlberg M. Platt G. Heller M. Mark Kudes 《Journal of nuclear cardiology》2005,12(2):S39-S40