睫状体平滑肌瘤症例报告

患者马××男性32岁住院号140194 左眼失明4天。左眼无其他病史。B超检查显示左球内占位性病变。1986年11月住院治疗。全身体检及实验室检查均未发现异常改变。视力右眼1.2,左眼无光感。左球结膜鼻侧上方血管明显变粗。该处巩膜表明有粗大新生血管,轻度隆起。角膜水肿,鼻侧前房消失,颞侧极浅。虹膜纹理不清,鼻侧向     

SPINDLE CELL CARCINOMA OF CORNEA AND CONJUNCTIVA WITH PSEUDOSARCOMATOUS METAPLASIA LIGHT MICROSCOPIC, ELECTRON MICROSCOPIC AND IMMUNOHISTOCHEMICAL FINDINGS IN 2 PATIENTS

We studied the electron microscopic and immu- nohistochemical findings in two elderly patients with spindle cell carcinoma of thecornea and conjunctiva.By light microscopy, correctdiagnosis was made by finding the transition between the pleomorphic spindle shaped tumor cells and the ovcrlying squamous epithelium. Ultrastructural findings indicated that squamous ceIJ origin included tonofilament-associated desmosomes and keratohyaline granules in the tumor cells. Positive immunohistochemical staining with antikeratin antibodies provided further evidence to prove the origin of spindle ceIJ carcinoma. Follow-up of the two patients showed the malignant tumor to bc quite aggressive in terms of intraocular invasion in the first patient and local recurrence in the second.     

纤维连接蛋白与髌软骨软化发生的关系

２４只新西兰兔，随机分为４组。右膝髌骨手术方法造成髌骨倾斜状态为实验侧，左膝实施假手术为对照侧，定期处死动物后进行软骨组织病理观察以及纤维连接蛋白的免疫组化（ＬＡＢ法）定位。结果：术后１２周实验膝髌内侧面软骨中层、深层细胞与细胞外基质变性并形成裂隙，与髌软骨软化的病理改变相似。上述软骨变性部位软骨细胞浆内以及细胞外软骨基质纤维连接蛋白明显增多，特别是软骨细胞周缘与基质交界处增多最显著。表明纤维连接蛋白增多部位与髌软骨软化部位一致，纤维连接蛋白增多与髌软骨软化的发生密切相关。