全文获取类型
收费全文 | 2258篇 |
免费 | 115篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 135篇 |
妇产科学 | 93篇 |
基础医学 | 213篇 |
口腔科学 | 59篇 |
临床医学 | 231篇 |
内科学 | 444篇 |
皮肤病学 | 23篇 |
神经病学 | 233篇 |
特种医学 | 351篇 |
外科学 | 213篇 |
综合类 | 11篇 |
预防医学 | 66篇 |
眼科学 | 18篇 |
药学 | 164篇 |
肿瘤学 | 118篇 |
出版年
2023年 | 14篇 |
2022年 | 17篇 |
2021年 | 40篇 |
2020年 | 19篇 |
2019年 | 34篇 |
2018年 | 31篇 |
2017年 | 22篇 |
2016年 | 26篇 |
2015年 | 54篇 |
2014年 | 57篇 |
2013年 | 59篇 |
2012年 | 85篇 |
2011年 | 91篇 |
2010年 | 73篇 |
2009年 | 63篇 |
2008年 | 79篇 |
2007年 | 109篇 |
2006年 | 93篇 |
2005年 | 87篇 |
2004年 | 83篇 |
2003年 | 53篇 |
2002年 | 55篇 |
2001年 | 41篇 |
2000年 | 35篇 |
1999年 | 49篇 |
1998年 | 112篇 |
1997年 | 78篇 |
1996年 | 87篇 |
1995年 | 64篇 |
1994年 | 64篇 |
1993年 | 72篇 |
1992年 | 29篇 |
1991年 | 36篇 |
1990年 | 28篇 |
1989年 | 51篇 |
1988年 | 37篇 |
1987年 | 51篇 |
1986年 | 32篇 |
1985年 | 37篇 |
1984年 | 29篇 |
1983年 | 21篇 |
1982年 | 29篇 |
1981年 | 28篇 |
1980年 | 30篇 |
1979年 | 7篇 |
1978年 | 18篇 |
1977年 | 21篇 |
1976年 | 23篇 |
1975年 | 16篇 |
1970年 | 2篇 |
排序方式: 共有2385条查询结果,搜索用时 32 毫秒
1.
Cost‐Effectiveness and Cost‐Utility Analysis of Spinal Cord Stimulation in Patients With Failed Back Surgery Syndrome: Results From the PRECISE Study 下载免费PDF全文
Furio Zucco MD Roberta Ciampichini MSc Angelo Lavano MD Amedeo Costantini MD Marisa De Rose MD Paolo Poli MD Gianpaolo Fortini MD Laura Demartini MD Enrico De Simone MD Valentino Menardo MD Piero Cisotto MD Mario Meglio MD Luciana Scalone PhD Lorenzo G. Mantovani DSc 《Neuromodulation》2015,18(4):266-276
2.
Needle-localized breast biopsy: why do we fail? 总被引:10,自引:0,他引:10
3.
Vincenzo Neri Antonio Ambrosi Giuseppe Di Lauro Tiziano Pio Valentino 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2006,10(1):66-69
OBJECTIVES: The aim of this study was to evaluate the safety and effectiveness of laparoscopic-assisted sigmoid colectomy for diverticulitis and to assess its postoperative advantages. METHODS: From 1999 to 2001, 5 patients were selectively operated on with a laparoscopic-assisted procedure for uncomplicated sigmoid diverticulitis. In the preceding period (September 1997 through December 1998), 4 patients underwent open procedures for the same pathology. The surgical indication with the same criteria was restrictive: at least 2 acute episodes had occurred that were treated with hospital admission and that were separated by an adequate period (2 months) of medical therapy. RESULTS: No conversions of laparoscopy to an open procedure were necessary. Age, sex, weight, morbidity, and mortality were similar between the 2 groups. Operative time was 180 minutes for laparoscopy and 120 minutes for laparotomy. Postoperative resumption of peristalsis was 24 hours versus 4 days, resumption of alimentation was on the second postoperative day versus the fifth postoperative day, and hospital stay was 7 days versus 12 days for laparoscopy and laparotomy, respectively. CONCLUSION: This study shows the feasibility and the advantages of elective laparoscopic-assisted colonic resection for uncomplicated sigmoid diverticulitis. The advantages of the laparoscopic approach are the lower need for analgesics and the more precocious ambulation, canalization, resumption of alimentation, and the shorter hospital stay. 相似文献
4.
Ketai LH; Williamson MR; Telepak RJ; Levy H; Koster FT; Nolte KB; Allen SE 《Radiology》1994,191(3):665
5.
6.
荧光原位杂交技术分析人结肠菌群方法研究 总被引:2,自引:0,他引:2
建立荧光原位杂交技术分析人体内结肠菌群的方法。取受试者新鲜粪便 ,选用 5种特异性的 16SrRNA寡核苷酸探针 ,检测粪便样本收集后的保存时间、温度 ,离心条件及样本固定液存放时间对杂交计数结果的影响。结果建立最佳实验条件为 :粪便样本收集后应尽快在 4℃下保存 ,放置时间不要超过 12小时即作处理 ;样本的适宜离心条件为 70 0g 2分钟 ;样本用多聚甲醛固定后在 - 80℃下存放时间不要超过 5个月。该方法具有较好的稳定性 ,可以有效地检出个体之间结肠菌群的差异。 相似文献
7.
8.
9.
The use of local dihematoporphyrin ether (DHE) injections, followed by laser light activation, was investigated as a potential permanent myectomy treatment for muscle spasms, in particular blepharospasm and hemifacial spasm. DHE was injected into the eyelids of rabbits, followed by laser activation, as used in photochemotherapy. Four days after treatment, histological examination indicated that doses of greater than or equal to 0.5 mg of DHE and laser treatment with an energy density of at least 100 J/cm2 resulted in an almost total destruction of the orbicularis oculi muscle in the treated eyelid. The amount of muscle injury was dependent on both dose of DHE and energy density levels. Histologically, the tarsal glands and conjunctiva were damaged. Glandular tissue was markedly reduced, and the conjunctival epithelium showed hyperplasia and a loss of mucous cells. Six months after DHE and laser treatment, the majority of the muscle tissue had regenerated, although there was evidence of previous injury. While DHE injections combined with laser light activation were lethal to muscle at the site of treatment, this treatment was not permanent. The orbicularis oculi muscle retained its ability to regenerate. However, photochemomyectomy may be studied further as an adjuvant treatment to temporarily injure and debulk large muscles when botulinum toxin is contraindicated due to the large doses involved or as a permanent treatment when used together with an antimitotic agent such as doxorubicin. 相似文献
10.
John Evans Pablo Bringas Jr. Masanori Nakamura Etsuko Nakamura Valentino Santos Professor Harold C. Slavkin 《Calcified tissue international》1988,42(4):220-230
Summary Biomineralization was investigated using embryonic mouse mandibular first molars (M1) cultured in the presence or absence of fetal calf serum. Metabolic features including cell division and Ca2+ and phosphate incorporation into dentine and enamel extracellular matrices were analyzed. The relative timing and magnitude
of DNA synthesis for serumless cultures was comparable toin vivo controls. Isotopic calcium and phosphate incorporation into the mineral phase of dentine and enamel matrices, in the absence
of serum, fluctuated during development. Molar tooth morphogenesis, cytodifferentiation, and extracellular matrix formation
approximated late crown-stage development in serumless cultures. Von Kossa histochemical staining indicated calcium phosphate
salt formation in serumless cultures. Analysis of anhydrous fixation-prepared enamel and dentine representing serumless cultured
explants indicated that crystal size and orientation were comparable toin vivo enamel and dentine. In contrast, serum-supplemented cultures showed atypical crystal size and orientation. Calcium/phosphorous
(Ca/P) ratio values for serumless cultures after 21 days showed Ca/P enamel values of 2.03 (SD±0.04, p<0.025) and dentine
values of 1.89 (SD±0.01, p<0.025). Electron diffraction patterns of enamel and dentine formed in serumless cultures were principally
those of highly-ordered crystalline hydroxyapatite. Our results suggest that tissue-specific dentine and enamel biomineralization
is regulated by endogenous factors intrinsic to the developmental program of embryonic tooth organs during serumless culture. 相似文献