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排序方式: 共有344条查询结果,搜索用时 19 毫秒
1.
Thomas Grunwald Manila Vannucci Nico Pezer Martin Kurthen Johannes Schramm Christian E Elger 《Clinical EEG and neuroscience》2007,38(3):143-147
Eye contact is a powerful social stimulus for human and non-human primates. However, it is unclear whether brain mechanisms that interpret eye contact are sensitive to gender. Here we show that human brain responses to eye contact are indeed gender specific. Recording event-related potentials directly from the medial temporal lobes, we found that eye contact elicited specific responses in men only when they saw female faces. Conversely, women responded specifically to eye contact only when they saw pictures of men. Thus, the human medial temporal lobes subserve specifically the processing of eye contact with persons of the opposite gender. 相似文献
2.
Ian A Simpson Anthony Carruthers Susan J Vannucci 《Journal of cerebral blood flow and metabolism》2007,27(11):1766-1791
Glucose is the obligate energetic fuel for the mammalian brain, and most studies of cerebral energy metabolism assume that the majority of cerebral glucose utilization fuels neuronal activity via oxidative metabolism, both in the basal and activated state. Glucose transporter (GLUT) proteins deliver glucose from the circulation to the brain: GLUT1 in the microvascular endothelial cells of the blood-brain barrier (BBB) and glia; GLUT3 in neurons. Lactate, the glycolytic product of glucose metabolism, is transported into and out of neural cells by the monocarboxylate transporters (MCT): MCT1 in the BBB and astrocytes and MCT2 in neurons. The proposal of the astrocyte-neuron lactate shuttle hypothesis suggested that astrocytes play the primary role in cerebral glucose utilization and generate lactate for neuronal energetics, especially during activation. Since the identification of the GLUTs and MCTs in brain, much has been learned about their transport properties, that is capacity and affinity for substrate, which must be considered in any model of cerebral glucose uptake and utilization. Using concentrations and kinetic parameters of GLUT1 and -3 in BBB endothelial cells, astrocytes, and neurons, along with the corresponding kinetic properties of the MCTs, we have successfully modeled brain glucose and lactate levels as well as lactate transients in response to neuronal stimulation. Simulations based on these parameters suggest that glucose readily diffuses through the basal lamina and interstitium to neurons, which are primarily responsible for glucose uptake, metabolism, and the generation of the lactate transients observed on neuronal activation. 相似文献
3.
Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development 总被引:6,自引:0,他引:6
Uda M Ottolenghi C Crisponi L Garcia JE Deiana M Kimber W Forabosco A Cao A Schlessinger D Pilia G 《Human molecular genetics》2004,13(11):1171-1181
FOXL2 mutations cause gonadal dysgenesis or premature ovarian failure (POF) in women, as well as eyelid/forehead dysmorphology in both sexes (the 'blepharophimosis-ptosis-epicanthus inversus syndrome', BPES). Here we report that mice lacking Foxl2 recapitulate relevant features of human BPES: males and females are small and show distinctive craniofacial morphology with upper eyelids absent. Furthermore, in mice as in humans, sterility is confined to females. Features of Foxl2 null animals point toward a new mechanism of POF, with all major somatic cell lineages failing to develop around growing oocytes from the time of primordial follicle formation. Foxl2 disruption thus provides a model for histogenesis and reproductive competence of the ovary. 相似文献
4.
Divya Sharma Manila Lather Cherry L. Dykes Amita S. Dang Tridibes Adak Om P. Singh 《Parasitology research》2016,115(1):323-328
5.
P. H. E. Arruda B. L. Arruda K. J. Schwartz F. Vannucci T. Resende A. Rovira P. Sundberg J. Nietfeld B. M. Hause 《Transboundary and Emerging Diseases》2017,64(2):311-315
An approximately 3,000 finishing swine operation in the United States experienced an outbreak of an atypical neurologic disease in 11‐weeks‐old pigs with an overall morbidity of 20% and case fatality rate of 30%. The clinical onset and progression of signs in affected pigs varied but included inappetence, compromised ambulation, ataxia, incoordination, mental dullness, paresis, paralysis and decreased response to environmental stimuli. Tissues from affected pigs were submitted for diagnostic investigation. Histopathologic examination of the cerebrum, cerebellum and spinal cord revealed severe lymphoplasmacytic and necrotizing polioencephalomyelitis with multifocal areas of gliosis and neuron satellitosis, suggestive of a neurotropic viral infection. Bacterial pathogens were not isolated by culture of neurologic tissue from affected pigs. Samples tested by polymerase chain reaction (PCR) were negative for pseudorabies virus and atypical porcine pestivirus. Immunohistochemistry for porcine reproductive and respiratory syndrome virus, porcine circovirus and Listeria was negative. Porcine sapelovirus (PSV) was identified in spinal cord by a nested PCR used to detect porcine enterovirus, porcine teschovirus and PSV. Next‐generation sequencing of brainstem and spinal cord samples identified PSV and the absence of other or novel pathogens. In addition, Sapelovirus A mRNA was detected in neurons and nerve roots of the spinal cord by in situ hybridization. The PSV is genetically novel with an overall 94% amino acid identity and 86% nucleotide identity to a recently reported sapelovirus from Korea. This is the first case report in the United States associating sapelovirus with severe polioencephalomyelitis in pigs. 相似文献
6.
7.
Francesco?PumaEmail author Jacopo?Vannucci Claudio?Fioroni Elisa?Scarnecchia Verena?De?Angelis Nicola?Avenia Mark?Ragusa Giuliano?Daddi 《Esophagus》2014,11(1):64-71
Background
The ideal surgical technique for symptomatic Zenker’s diverticulum has not been identified yet. Endoscopic treatment, although frequently performed, has not replaced the open cricopharyngeal myotomy, which is still deemed the standard therapy by many dedicated physicians. The management of the diverticular sac after myotomy is still a matter of debate. The aim of this study is to compare the results of diverticulectomy and diverticulopexy after cricopharyngeal myotomy, in homogeneous groups of patients.Methods
Thirty-seven patients were treated for Zenker’s diverticulum at the same university medical school, but in two different units, with open cricopharyngeal myotomy, associated with diverticulectomy in 17 patients and with diverticulopexy in the remaining. No clinical criteria influenced the different choice of treatment of the diverticular pouch, but only the surgeon’s preference. Clinical data, diverticulum size, postoperative course, and complications were analyzed. Patients were followed up for median duration of 37 months (range 12–113 months) through contrast swallow study and clinical evaluation, aided by a specifically conceived questionnaire. Records were analyzed by Mann–Whitney–Wilcoxon test and Fisher’s exact test.Results
Homogeneous comparative values for sex, age, diverticulum size, and symptoms were found in the two groups. Statistical analysis indicated that diverticulopexy, as compared with diverticulectomy, allowed reduced postoperative complications and slightly improved long-term swallowing.Conclusions
Diverticulopexy is feasible also in large Zenker’s diverticula and can achieve equivalent or even better results than diverticulectomy with a smoother postoperative course.8.
Andrey Korshunov Dominik Sturm Marina Ryzhova Volker Hovestadt Marco Gessi David T. W. Jones Marc Remke Paul Northcott Arie Perry Daniel Picard Marc Rosenblum Manila Antonelli Eleonora Aronica Ulrich Schüller Martin Hasselblatt Adelheid Woehrer Olga Zheludkova Ella Kumirova Stephanie Puget Michael D. Taylor Felice Giangaspero V. Peter Collins Andreas von Deimling Peter Lichter Annie Huang Torsten Pietsch Stefan M. Pfister Marcel Kool 《Acta neuropathologica》2014,128(2):279-289
Three histological variants are known within the family of embryonal rosette-forming neuroepithelial brain tumors. These include embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), and medulloepithelioma (MEPL). In this study, we performed a comprehensive clinical, pathological, and molecular analysis of 97 cases of these rare brain neoplasms, including genome-wide DNA methylation and copy number profiling of 41 tumors. We identified uniform molecular signatures in all tumors irrespective of histological patterns, indicating that ETANTR, EBL, and MEPL comprise a single biological entity. As such, future WHO classification schemes should consider lumping these variants into a single diagnostic category, such as embryonal tumor with multilayered rosettes (ETMR). We recommend combined LIN28A immunohistochemistry and FISH analysis of the 19q13.42 locus for molecular diagnosis of this tumor category. Recognition of this distinct pediatric brain tumor entity based on the fact that the three histological variants are molecularly and clinically uniform will help to distinguish ETMR from other embryonal CNS tumors and to better understand the biology of these highly aggressive and therapy-resistant pediatric CNS malignancies, possibly leading to alternate treatment strategies. 相似文献
9.
Vannucci M Mazzoni G Marchetti I Lavezzini F 《Archives of gerontology and geriatrics》2012,54(2):310-316
Memory for visual objects, although typically highly accurate, can be distorted, especially in older adults. Here we asked whether also erroneous identifications of visual objects subsequently corrected and replaced by a correct identification might induce false recognitions, and whether this is more likely to occur in older people. For this aim a new paradigm was developed. In the first phase, participants performed a visual object identification task with degraded pictures of objects and produced correct and false but subsequently corrected identifications. In the second phase, participants performed a surprise recognition task in which also false identifications were presented. False identifications elicited false recognitions, with a stronger and more reliable effect in elderly participants, suggesting that correcting the initial visual error is not sufficient to correct the memory for the experience. Moreover, misidentification-related false recognitions coexisted in memory along with correct recognitions of correct identifications. These findings are discussed in relation with age-related deficits in memory updating and strategic retrieval. 相似文献
10.
Daniele Doná Juan Torres Canizales Elisa Benetti Mara Cananzi Federica De Corti Elisabetta Calore Loreto Hierro Esther Ramos Boluda Marta Melgosa Hijosa Luis Garcia Guereta Antonio Pérez Martínez Maribel Barrios Patricia Costa Reis Ana Teixeira Maria Francelina Lopes Piotr Kaliciński Sophie Branchereau Olivia Boyer Dominque Debray Marco Sciveres Lars Wennberg Björn Fischler Peter Barany Alastair Baker Ulrich Baumann Nicolaus Schwerk Emanuele Nicastro Manila Candusso Jacek Toporski Etienne Sokal Xavier Stephenne Caroline Lindemans Marius Miglinas Jelena Rascon Paloma Jara ERN TransplantChild 《Clinical transplantation》2020,34(10):e14063
The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 outbreak on pediatric transplant activity and healthcare practices in both solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT). The replies of 30 professionals from 18 centers in Europe were collected. Twelve of 18 centers (67%) showed a reduction in their usual transplant activity. Additionally, outpatient visits have been modified and restricted to selected ones, and the use of telemedicine tools has increased. Additionally, a total of 14 COVID-19 pediatric transplanted patients were identified at the time of the survey, including eight transplant recipients and six candidates for transplantation. Only two moderate-severe cases were reported, both in HSCT setting. These survey results demonstrate the limitations in healthcare resources for pediatric transplantation patients during early stages of this pandemic. COVID-19 disease is a major worldwide challenge for the field of pediatric transplantation, where there will be a need for systematic data collection, encouraging regular discussions to address the long-term consequences for pediatric transplantation candidates, recipients, and their families. 相似文献