全文获取类型
收费全文 | 193篇 |
免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 14篇 |
基础医学 | 12篇 |
口腔科学 | 6篇 |
临床医学 | 3篇 |
内科学 | 108篇 |
皮肤病学 | 5篇 |
神经病学 | 25篇 |
特种医学 | 2篇 |
外科学 | 6篇 |
预防医学 | 2篇 |
眼科学 | 2篇 |
药学 | 8篇 |
肿瘤学 | 1篇 |
出版年
2023年 | 3篇 |
2022年 | 1篇 |
2021年 | 7篇 |
2020年 | 1篇 |
2019年 | 3篇 |
2018年 | 5篇 |
2017年 | 2篇 |
2016年 | 2篇 |
2015年 | 5篇 |
2014年 | 10篇 |
2013年 | 5篇 |
2012年 | 10篇 |
2011年 | 13篇 |
2010年 | 7篇 |
2009年 | 1篇 |
2008年 | 6篇 |
2007年 | 13篇 |
2006年 | 11篇 |
2005年 | 10篇 |
2004年 | 20篇 |
2003年 | 16篇 |
2002年 | 21篇 |
2001年 | 2篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1998年 | 3篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1988年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1977年 | 2篇 |
1971年 | 1篇 |
排序方式: 共有195条查询结果,搜索用时 0 毫秒
1.
Marcelo Biscegli Jatene Estela Azeka Edmar Atik Arlindo Riso Carla Tanamati Miguel Barbero Marcial Sergio Almeida de Oliveira 《The Journal of heart and lung transplantation》2005,24(5):638-641
A 28-month-old boy, weighing 11 kg, with severe dilated cardiomyopathy, was transplanted on December 1995. Hypertension and supraventricular tachycardia were detected in the immediate post-operative period, with favorable outcome. After 5 months of clinically asymptomatic follow-up, a dilation in the ascending aorta was observed on routine echocardiogram. Nuclear magnetic resonance imaging (NMRI) confirmed an ascending aortic aneurysm, with a diameter of 38 mm. An operation was performed, a bovine pericardium patch was sutured with reconstruction of the aortic wall, excluding the aneurysm. Good recovery was obtained and the child was discharged on Day 7 postoperatively. A post-operative echocardiogram showed absence of the aortic aneurysm and good surgical results. Another NMRI was done 5 months later, showing an intact ascending aorta. After 64 months, the patients clinical condition was confirmed as normal by echocardiogram. Surgical treatment was successful and the positive results have been maintained. 相似文献
2.
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis. 总被引:12,自引:0,他引:12
Philip Washbourne Peter M Thompson Mario Carta Edmar T Costa James R Mathews Guillermina Lopez-Benditó Zoltán Molnár Mark W Becher C Fernando Valenzuela L Donald Partridge Michael C Wilson 《Nature neuroscience》2002,5(1):19-26
Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated-soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis. 相似文献
3.
4.
5.
6.
7.
Rodrigo Holanda Mendonça Ligia Maria Sotero Machado Carlos Otto Heise Graziela Jorge Polido Ciro Matsui André Macedo Serafim Silva Umbertina Conti Reed Edmar Zanoteli 《Neuromuscular disorders : NMD》2021,31(6):498-504
Spinal muscular atrophy (SMA) is a motor neuron disease associated with progressive muscle weakness and motor disability. The motor unit number index (MUNIX) is a biomarker used to assess loss of motor units in later-onset SMA patients. Twenty SMA patients (SMA types 3 and 4), aged between 7 and 41 years, were clinically evaluated through the Hammersmith Motor Functional Scale Expanded and the Spinal Muscular Atrophy-Functional Rating Scale. The patients underwent compound motor action potential (CMAP) and MUNIX studies of the right abductor pollicis brevis, abductor digiti minimi and tibialis anterior (TA) muscles. Age-matched healthy controls (n = 20) were enrolled to obtain normative CMAP and MUNIX values from the same muscles. Compared to healthy controls, SMA patients showed significant reductions in MUNIX values among all muscles studied, whereas CMAP showed reductions only in the weaker muscles (abductor digiti minimi and TA). MUNIX variability was significantly higher in the SMA group than in the control group. MUNIX variability in TA correlated with CMAP variability. Motor functional scores correlated with TA MUNIX. The MUNIX study is feasible in later-onset SMA patients, and TA MUNIX values correlate with disease severity in patients with mild motor impairment. 相似文献
8.
9.
10.